Irisin ameliorates myocardial ischemia-reperfusion injury by modulating gut microbiota and intestinal permeability in rats

Liu, Qingqing; Zhu, Yu; Li, Guangyao; Guo, Tiantian; Jin, Mengtong; Xi, Duan; Wang, Shuai; Liu, Xuezhi; Guo, Shuming; Liu, Hui; Fan, Jiamao; Liu, Ronghua

doi:10.1371/journal.pone.0291022

Cited by 4 publications

(4 citation statements)

References 47 publications

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“…Streptococcuis an important pathogen that causes bacterial meningitis. Actinobacteriota and Aeriscardovia may also have certain pro-inflammatory effects (Liu et al, 2023). It was inferred that there may be some connection between inflammatory factors and intestinal flora composition and that PAS has a positive effect on resistance to inflammatory bowel disease in Hu sheep.…”

Section: Discussionmentioning

confidence: 99%

Prickly Ash Seeds improve immunity of Hu sheep by changing the diversity and structure of gut microbiota

Li,

Yang,

et al. 2023

Front. Microbiol.

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Prickly Ash Seeds (PAS), as a traditional Chinese medicinal herb, have pharmacological effects such as anti-asthma, anti-thrombotic, and anti-bacterial, but their impact on gut microbiota is still unclear. This study used a full-length 16 s rRNA gene sequencing technique to determine the effect of adding PAS to the diet on the structure and distribution of gut microbiota in Hu sheep. All lambs were randomly divided into two groups, the CK group was fed with a basal ration, and the LZS group was given a basal diet with 3% of PAS added to the ration. The levels of inflammatory factors (IL-10, IL-1β, and TNF-α) in intestinal tissues were measured by enzyme-linked immunosorbent assay (ELISA) for Hu sheep in the CK and LZS group. The results indicate that PAS can increase the diversity and richness of gut microbiota, and can affect the community composition of gut microbiota. LEfSe analysis revealed that Verrucomicrobiota, Kiritimatiella, WCHB 41, and uncultured_rumen_bacterium were significantly enriched in the LZS group. KEGG pathway analysis found that LZS was significantly higher than the CK group in the Excretory system, Folding, sorting and degradation, and Immune system pathways (p < 0.05). The results of ELISA assay showed that the level of IL-10 was significantly higher in the LZS group than in the CK group (p < 0.05), and the levels of TNF-α and IL-1β were significantly higher in the CK group than in the LZS group (p < 0.05). LEfSe analysis revealed that the dominant flora in the large intestine segment changed from Bacteroidota and Gammaproteobacteria to Akkermansiaceae and Verrucomicrobiae after PAS addition to Hu sheep lambs; the dominant flora in the small intestine segment changed from Lactobacillales and Aeriscardovia to Kiritimatiellae and WCHB1 41. In conclusion, the addition of PAS to sheep diets can increase the number and types of beneficial bacteria in the intestinal tract, improve lamb immunity, and reduce intestinal inflammation. It provides new insights into healthy sheep production.

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Section: Discussionmentioning

confidence: 99%

Prickly Ash Seeds improve immunity of Hu sheep by changing the diversity and structure of gut microbiota

Li,

Yang,

et al. 2023

Front. Microbiol.

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“…51 Interestingly, it has been reported that irisin administration can counterbalance gut dysbiosis and improve the integrity of the gut mucosal barrier induced in rats that underwent an experimental model of myocardial ischemia-reperfusion injury with MIF. 52…”

Section: Harnessing the Beneficial Effects Of Diet And Exercise Media...mentioning

confidence: 99%

Possible Role of Gut Microbiota Alterations in Myocardial Fibrosis and Burden of Heart Failure in Hypertensive Heart Disease

Pitt,

Diez

2024

Hypertension

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Epidemiological studies have revealed that hypertensive heart disease is a major risk factor for heart failure, and its heart failure burden is growing rapidly. The need to act in the face of this threat requires first an understanding of the multifactorial origin of hypertensive heart disease and second an exploration of new mechanistic pathways involved in myocardial alterations critically involved in cardiac dysfunction and failure (eg, myocardial interstitial fibrosis). Increasing evidence shows that alterations of gut microbiota composition and function (ie, dysbiosis) leading to changes in microbiota-derived metabolites and impairment of the gut barrier and immune functions may be involved in blood pressure elevation and hypertensive organ damage. In this review, we highlight recent advances in the potential contribution of gut microbiota alterations to myocardial interstitial fibrosis in hypertensive heart disease through blood pressure–dependent and blood pressure–independent mechanisms. Achievements in this field should open a new path for more comprehensive treatment of myocardial interstitial fibrosis in hypertensive heart disease and, thus, for the prevention of heart failure.

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“…By studying the effects of irisin administration in a mouse model of UC, an improvement in the inflammatory status involving decreases in IL-12 and IL-23 plasma levels [202], both interleukins involved in the amplification and differentiation of the T-helper (Th) type 1 (Th1) and type 17 (Th17) lymphocyte response [203,204], and the reversal of gut microbial communities that were found abnormally represented in UC mice (e.g., Bacteroides and Lactobacillaceae) were shown. Another recent study has demonstrated that irisin administration can improve the integrity of the gut mucosal barrier and can counterbalance the gut dysbiosis induced in rats that underwent an experimental model of myocardial ischemia-reperfusion injury [205]. Equally illustrative of the capacity demonstrated by irisin to attenuate intestinal damage is one study in which irisin administration was used to reduce injury to epithelial cells, as well as apoptosis and oxidative stress in a mouse model of acute pancreatitis [206].…”

Section: Irisin and Bdnf Are Paradigmatic Myokines Linking Physical A...mentioning

confidence: 99%

Physical Exercise as Disease-Modifying Alternative against Alzheimer’s Disease: A Gut–Muscle–Brain Partnership

Cutuli,

Decandia,

Giacovazzo

et al. 2023

IJMS

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Alzheimer’s disease (AD) is a common cause of dementia characterized by neurodegenerative dysregulations, cognitive impairments, and neuropsychiatric symptoms. Physical exercise (PE) has emerged as a powerful tool for reducing chronic inflammation, improving overall health, and preventing cognitive decline. The connection between the immune system, gut microbiota (GM), and neuroinflammation highlights the role of the gut–brain axis in maintaining brain health and preventing neurodegenerative diseases. Neglected so far, PE has beneficial effects on microbial composition and diversity, thus providing the potential to alleviate neurological symptoms. There is bidirectional communication between the gut and muscle, with GM diversity modulation and short-chain fatty acid (SCFA) production affecting muscle metabolism and preservation, and muscle activity/exercise in turn inducing significant changes in GM composition, functionality, diversity, and SCFA production. This gut–muscle and muscle–gut interplay can then modulate cognition. For instance, irisin, an exercise-induced myokine, promotes neuroplasticity and cognitive function through BDNF signaling. Irisin and muscle-generated BDNF may mediate the positive effects of physical activity against some aspects of AD pathophysiology through the interaction of exercise with the gut microbial ecosystem, neural plasticity, anti-inflammatory signaling pathways, and neurogenesis. Understanding gut–muscle–brain interconnections hold promise for developing strategies to promote brain health, fight age-associated cognitive decline, and improve muscle health and longevity.

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Irisin ameliorates myocardial ischemia-reperfusion injury by modulating gut microbiota and intestinal permeability in rats

Cited by 4 publications

References 47 publications

Prickly Ash Seeds improve immunity of Hu sheep by changing the diversity and structure of gut microbiota

Prickly Ash Seeds improve immunity of Hu sheep by changing the diversity and structure of gut microbiota

Possible Role of Gut Microbiota Alterations in Myocardial Fibrosis and Burden of Heart Failure in Hypertensive Heart Disease

Physical Exercise as Disease-Modifying Alternative against Alzheimer’s Disease: A Gut–Muscle–Brain Partnership

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