Irisin – a new mediator of energy homeostasis

Pukajło, Katarzyna; Kolačkov, Katarzyna; Łaczmański, Łukasz; Daroszewski, Jacek

doi:10.5604/17322693.1141097

Cited by 21 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Physical activity influences irisin release, which already in a small concentration affects the “beigeing” of adipose tissue. Beige fat tissue (“beige” or “brite” beige-in-white) resembles brown adipose tissue (BAT) with structure and function [ 38 ]. Brown adipocytes are formed from myoblasts.…”

Section: Discussionmentioning

confidence: 99%

Blood lipid profile and body composition in a pediatric population with different levels of physical activity

et al. 2018

View full text Add to dashboard Cite

BackgroundAssociations between physical activity and lipid/lipoprotein levels and body composition among pediatric populations are not completely consistent in the literature. Accordingly, the aim of this study was to analyze lipid and lipoprotein profiles and body composition among children and adolescents differentiated according to their level of physical activity.MethodsThe study sample consisted of 69 participants that ranged from 6 to 17 years of age. Objective measures of physical activity were obtained over 7 days with accelerometers. Total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides (TG) were measured from a fasting blood sample. High-risk values for these lipids/lipoproteins were determined using age- and sex-specific thresholds. Body composition estimates were obtained using a foot-to-foot bioelectrical impedance analysis.ResultsAlmost half (47.8%) of the participants did not meet daily moderate-to-vigorous intensity physical activity (MVPA) recommendations. This group had lower free fat mass (by 5.51%), muscle mass content (by 5.17%), and a higher risk for abnormal HDL level (OR = 4.19) and excessive body fat content (OR = 3.05).ConclusionsParticipants who met daily recommended MVPA were found to have more favorable HDL and body fat levels compared to those who did not meet these recommendations.

show abstract

Section: Discussionmentioning

confidence: 99%

Blood lipid profile and body composition in a pediatric population with different levels of physical activity

et al. 2018

View full text Add to dashboard Cite

show abstract

“…That molecule was able to induce changes in adipose tissue and activate thermogenesis [4]. Moreover, that molecule was proposed to act as a link between the muscles and other tissues of the body; the newly discovered protein has been called “irisin,” derived from the name of the Greek goddess Iris [5]. Since then, irisin has been the subject of extensive research, which enabled the gaining of insight into its pleiotropic properties.…”

Section: Introductionmentioning

confidence: 99%

Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases

2019

View full text Add to dashboard Cite

Sedentary life style is considered to be an independent risk factor for many disorders, including development of type 2 diabetes, obesity, immune dysfunction, asthma, and neurological or coronary heart disease. Irisin is released from myocytes during physical activity, and acts as a link between muscles and other tissues and organs. This myokine is produced as a result of proteolytic cleavage of FNDC5 protein present in the membrane of myocytes. Secretion of irisin is regulated by N-linked oligosaccharides attached to the protein molecule. The two N-glycan molecules, which constitute a significant part of the irisin glycoprotein, regulate the browning of adipocytes, which is the most important function of irisin. A receptor specific for irisin has still not been discovered. In some tissues irisin probably acts via integrins, which are widely expressed transmembrane receptors. Many studies have confirmed the multifunctional role of irisin and the beneficial effects of this molecule on body homeostasis. Irisin reduces systemic inflammation, maintains the balance between resorption and bone formation, and modulates metabolic processes and the functioning of the nervous system. It suppresses the expression and release of pro-inflammatory cytokines in obese individuals and attenuates inflammation in adipose tissue. The impact of irisin on cancer cell proliferation, migration, and invasion has also been demonstrated in numerous studies, which proves its role in carcinogenesis. Owing to these pleiotropic and beneficial properties, irisin may be a potential option to prevent and treat civilization-related diseases which are, nowadays, considered to be the major health problems in Western societies.

show abstract

“…Irisin is a part of the muscle secretome and it is formed by the proteolytic cleavage of the membrane-bound fibronectin type III domain containing five proteins (FNDC5) [2,3,4]. Irisin plays a pleiotropic role in the metabolism [5].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation

Mazur-Biały

Pocheć

Zarawski³

2017

IJMS

157

113

View full text Add to dashboard Cite

Irisin, an adipomiokine known as a mediator of physical activity, induces the browning of adipose tissue and it has potentially protective properties in the development of obesity-related states, such as insulin resistance, arteriosclerosis, and type 2 diabetes. Despite numerous studies conducted on this factor, still little is known about its impact on the functioning of immunocompetent cells, but its potential anti-inflammatory properties were previously suggested. In the current study we investigated the role of irisin (0–100 nM) in the downstream pathway activation of Toll-like receptor 4 (TLR4) in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS; 100 ng/mL). The results have shown that irisin in high concentrations (50, 100 nM) significantly decreased the TLR4 and MyD88 protein levels, as well as the phosphorylation of nuclear factor-κB (NF-κB), consequently leading to the reduction in the release of crucial pro-inflammatory cytokines. The above was confirmed for interleukin 1β (IL-1β), tumor necrosis factor α (TNFα), interleukin 6 (IL-6), keratinocyte chemoattractant (KC), monocyte chemotactic protein 1 (MCP-1), as well as for high mobility group box 1 (HMGB1). Moreover, our results indicate that this effect is connected with irisin’s impact on the phosphorylation of mitogen-activated protein kinases (MAPKs), where a significant reduction in p-JNK and p-ERK but not p-p38 was observed. In conclusion, these data suggest that irisin has potentially anti-inflammatory properties connected with the downregulation of downstream pathways of TLR4/MyD88.

show abstract

Irisin – a new mediator of energy homeostasis

Cited by 21 publications

References 0 publications

Blood lipid profile and body composition in a pediatric population with different levels of physical activity

Blood lipid profile and body composition in a pediatric population with different levels of physical activity

Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases

Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation

Contact Info

Product

Resources

About