Iris Nevus (Cogan-Reese) Syndrome

Clinical and histopathologic findings of iris nevus (Cogan‐Reese) syndrome

“…Electron microscopic studies have revealed that the corneal endothelial cells are flattened, they involve many endoplasmic reticula and intracytoplasmic filaments of 80-100 Aae diameter, and the descemet membrane is thickened. There is a membrane composed of endothelium and abnormal basal membrane on the trabeculum and the iris, with many melanocytic cells in the iris stroma (Eagle et al 1980;Scheie & Yanoff 1975). The iris atrophy and multiple pigmented nodules were observed at slit-lamp and gonioscopic examinations of our case and this is in favour of the diagnosis of iris nevus (Cogan-Reese) syndrome.…”

“…It is not associated with any systemic disease. The patients complain of blurred vision, ocular pain, heterochromia and distorted pupil (Eagle et al 1980;Scheie & Yanoff 1975;Shields et al 1976;Kidd et al 1988;Scheie et al 1976;Laganowski et al 1992).…”

“…Iris anomalies in the ICE syndrome develop secondary to the endothelial membrane on its anterior surface and the iris anomalies vary according to the variations in amount, rate, and the pattern of endothelial proliferation. These clinical entities overlap each other during the progression of the disease, so that the differential diagnosis might be difficult (Scheie & Yanoff 1975;Shields et al 1976;Kidd et al 1988).…”

Iridoschisis: case report and review of the literature

“…In Axenfeld-Rieger syndrome, there is mild stromal thinning of the iris, atrophy, and hole formation, and peripheral anterior synechiae are observed on the anteriorly displaced Schwalbe’s line. The pupil may be irregular, and the cornea presents with endothelial changes related to peripheral anterior synechiae 1,22–25. According to the aforementioned clinical entities, our patient had the differential characteristics of iridoschisis, although the exclusion of a diagnosis of iridocorneal endothelial syndrome or Axenfeld-Rieger syndrome can be sometimes difficult.…”

Diffuse Malignant Ring Melanoma of the Iris and Ciliary Body

“…The enucleation in case 1 was based on a correct clinical diagnosis; while case 2 was subjected to antiglaucomatous surgery 2 years prior to enucleation. The absence of peripheral anterior synechias, the pres ence of tumor tissue in the angle and the pathological fluorescein angioscopy differ entiated them from the Cogan-Recse iris nevus syndrome [1,10].…”