Iris-fixated phakic intraocular lens implantation to correct myopia and a predictive model of endothelial cell loss

Bouheraoua, Nacim; Bonnet, Clémence; Labbé, Antoine; Sandali, Otman; Lecuen, Nicolas; Améline, B; Laroche, L.

doi:10.1016/j.jcrs.2015.05.030

Cited by 13 publications

(16 citation statements)

References 22 publications

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“…Our results are in good agreement with other studies which showed successful refractive results of IF pIOLs implantation [ 7 , 10 , 11 , 14 , 23 , 24 ]. Tahzib et al reported the MRSE −0.7 ± 1.0 D after 10 years, with no significant change in MRSE between 1, 6, and 10 years.…”

Section: Discussionsupporting

confidence: 93%

“…Bouheraoua et al performed a linear model analysis of the 5-year follow-up to present a model that describes endothelial cell loss as a linear decrease. This model predicted that for patients with preoperative ECD of 3000, 2500, and 2000 cells/mm 2 , a critical ECD of 1500 cells/mm 2 will be reached at 39, 28, and 15 years after the implantation, respectively [ 7 ]. Such a model seems to be very useful and helps us to improve the inclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

“…Jonker et al used ECD >2800 cells/mm 2 for patients aged 21 to 25 years, >2650 cells/mm 2 for patients aged 26 to 30 years, >2400 cells/mm 2 for patients aged 31 to 35 years, >2200 cells/mm 2 for patients aged 36 to 45 years, and >2000 cells/mm 2 for patients aged more than 45 years [9]. ese criteria are more strict than those that were previously recommended by G} uell et al and others [1,3,7,16].…”

Section: Endothelial Cell Lossmentioning

confidence: 99%

“…Detection of basic risk factors showed to be important for correct indication and minimization of postoperative complications. Most of the publications reported 5-year results [4][5][6][7][8], but only a few of them spanned more than 10 years [9][10][11][12][13][14][15]. In this paper, we show our results of a 12-year follow-up of myopic patients cohort after implantation of Verisyse myopia, Verisyse myopia toric, and Veriflex pIOL (Abbott Medical Optics, Inc.) lenses.…”

Section: Introductionmentioning

confidence: 96%

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Myopic Correction with Iris-Fixated Phakic Intraocular Lenses: Twelve-Year Results

Nemcova

Pasta

Hladíková

et al. 2021

Journal of Ophthalmology

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Purpose. To evaluate a 12-year follow-up of myopic patients after iris-fixated phakic intraocular lenses (IF pIOLs) implantation. Setting. Ophthalmology Department, Military University Hospital in Prague (Czech Republic). Design. Single-center retrospective cohort study. Methods. We describe the results of a cohort study that included 85 eyes of 46 myopic patients who underwent implantation of Verisyse myopia, Veriflex, and Verisyse myopia toric (all Abbott Medical Optics, Inc.) intraocular lenses. Refractive functions and adverse events were assessed preoperatively, at 6 months, and 1, 2, 5, and 12 years after IF pIOL implantation. Results. Mean spherical equivalent was measured as −9.37 ± 2.87 D, 0.14 ± 0.61 D, and −0.42 ± 1.08 D, preoperatively, at 6 months and 12 years postoperatively, respectively. There was a significant reduction in the cylinder after surgery. At 12 years postoperatively, 90% of eyes had uncorrected distance visual acuity (UDVA) of 20/40 and 64% of 20/20. The safety index was 1.10 for the whole postoperative follow-up period. We found cataract formation in 3 eyes (3.5%). The endothelial cells loss (EC loss) directly caused by IF pIOL implantation was 6.0%, 8.10%, 12.8%, and 11.9%, at 1, 2, 5, and 12 years, respectively. In our cohort, 95% of eyes lost a higher percentage of EC than would be expected from a physiological loss at 12 years postoperatively. We found a significant negative interaction between preoperative pachymetry and EC loss, indicating that the lower pachymetry leads to a faster decline in endothelial cells density (ECD). IF pIOL re-enclavation was found in 28% of eyes. 7% of subluxations were caused by trauma. The mean time of nontraumatic re-enclavation was 6 years postoperatively. Conclusions. The study confirmed the advantages of IF pIOL implantation due to rapid visual recovery and stable visual function over the 12-year follow-up and also showed the influence of lower corneal pachymetry regarding EC loss.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Endothelial Cell Lossmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Myopic Correction with Iris-Fixated Phakic Intraocular Lenses: Twelve-Year Results

Nemcova

Pasta

Hladíková

et al. 2021

Journal of Ophthalmology

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“…However, some researchers have not detected such association, e.g. Bouheraroua et al and Galvis et al [8,16].…”

Section: Discussionmentioning

confidence: 97%

Determination of Factors Associated With Long-Term Endothelial Loss and Refractive Result in Patients With Artisan Phakic Lens

Martínez¹,

Tello²,

Galvis³

et al. 2022

CSO

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Purpose: To determine the changes in endothelial cell density, refractive results, and risk factors associated with endothelial loss in patients with iris-claw phakic intraocular lenses for myopia/myopic astigmatism (Artisan). Methodology: Data collection was obtained from an existing database with information on patients with a phakic Artisan lens implant between 1998 and 2011 at the Virgilio Galvis Ophthalmology Centre, with at least 5 years of follow-up. As a second stage, an analysis was carried out to identify the change in endothelial cell density and its potential associated factors. Results: A total of 80 eyes with myopic errors were included with a follow-up of 11.9 + 3.48 years. The percentage of total loss of endothelial cells was greater than 25% of the preoperative density in 43.8% of the eyes. A postoperative annual loss > 1.6% was found in 47.0% of the eyes with that information available. 41 eyes (51%) had final endothelial density < 2000 cells/mm2, and 7 (8.8%) eyes had endothelial cell density < 1000 cells/mm2. Among the variables studied, no associated factors for long-term endothelial loss were found. During the course of the study, 8 (10%) phakic intraocular lenses were explanted, including 3 with accelerated endothelial loss, and another 2 with cataract associated and a significantly low endothelial density. The last mean spherical equivalent was -0.81 (±1.01 D), and the final uncorrected distance visual acuity was 0.45 logMar (Snellen 20/56). Conclusion: Artisan-type phakic lenses are a good alternative for the correction of high myopic defects, with predictable refractive results in the long term. However, there is an increased loss of endothelial cells in the long term in a high percentage of patients. Strict postoperative follow-up, including endothelial evaluation, is required, and further studies are warranted.

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Phakic Intraocular Lens Implantation in Keratoconus

Krakauer

Lifshitz

2018

Controversies in the Management of Keratoconus

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Iris-fixated phakic intraocular lens implantation to correct myopia and a predictive model of endothelial cell loss

Abstract: The authors report no conflict of interest.

Cited by 13 publications

References 22 publications

Myopic Correction with Iris-Fixated Phakic Intraocular Lenses: Twelve-Year Results

Myopic Correction with Iris-Fixated Phakic Intraocular Lenses: Twelve-Year Results

Determination of Factors Associated With Long-Term Endothelial Loss and Refractive Result in Patients With Artisan Phakic Lens

Phakic Intraocular Lens Implantation in Keratoconus

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