Iris Crystals in Fuchs' Heterochromic Iridocyclitis

Zamir, Ehud; Margalit, Eyal; Chowers, Itay

doi:10.1001/archopht.116.10.1394

Cited by 13 publications

(6 citation statements)

References 3 publications

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“…Synechiae formation may rarely occur transitorily in the area of the Koeppe's nodules, leaving typical radial pigmented lines on the anterior surface of the lens . Small, refractile iris crystals representing Russell bodies are also typical of FUS …”

Section: Clinical Features Of Viral Anterior Uveitismentioning

confidence: 99%

“…4 Small, refractile iris crystals representing Russell bodies are also typical of FUS. 28 Vitritis is seen in almost all cases of RV-associated FUS 29 but is rare in CMV infection. Although the vitritis may even be so significant as to obscure the view of the fundus, visual acuity remains good as there is no associated cystoid macular oedema, unlike in intermediate uveitis.…”

Section: Clinical Signsmentioning

confidence: 99%

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Demystifying viral anterior uveitis: A review

Chan

Chee

2018

Clinical Exper Ophthalmology

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A viral aetiology should be suspected when anterior uveitis is accompanied by ocular hypertension, diffuse stellate keratic precipitates or the presence of iris atrophy. The most common viruses associated with anterior uveitis include herpes simplex virus, varicella‐zoster virus, cytomegalovirus and rubella virus. They may present as the following: Firstly, granulomatous cluster of small and medium‐sized keratic precipitates in Arlt's triangle, with or without corneal scars, suggestive of herpes simplex or varicella‐zoster virus infection. Secondly, Posner‐Schlossman syndrome with few medium‐sized keratic precipitates, minimal anterior chamber cells and extremely high intraocular pressure; this is mainly associated with cytomegalovirus. Thirdly, Fuchs uveitis syndrome, with fine stellate keratic precipitates diffusely distributed over the corneal endothelium, with diffuse iris stromal atrophy but without posterior synechiae, is associated mainly with rubella or cytomegalovirus infection. In rubella, the onset is in the second to third decade. It presents with posterior subcapsular cataract, may have iris heterochromia and often develops vitritis without macular oedema. Cytomegalovirus affects predominantly Asian males in the fifth to seventh decade, the keratic precipitates may be pigmented or appear in coin‐like pattern or develop nodular endothelial lesions, but rarely vitritis. Eyes with cytomegalovirus tend to have lower endothelial cell counts than the fellow eye. As their ocular manifestations are variable and may overlap considerably, viral AU can pose a diagnostic dilemma. Thus, quantitative polymerase chain reaction or Goldmann‐Witmer coefficient assay from aqueous humour samples are preferred to confirm the aetiology and determine the disease severity as this impacts the treatment.

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Section: Clinical Features Of Viral Anterior Uveitismentioning

confidence: 99%

Section: Clinical Signsmentioning

confidence: 99%

Demystifying viral anterior uveitis: A review

Chan

Chee

2018

Clinical Exper Ophthalmology

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“…Small, refractile iris crystals are typical of FUS. 22,23 These crystals represent Russell bodies and can occur in other chronic uveitidies. 23,24 There is minimal and variable cell and flare.…”

Section: History and Clinical Featuresmentioning

confidence: 99%

Fuchs’ Uveitis Syndrome and Glaucoma

Filho

Liesegang

2010

The Glaucoma Book

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“…[1] Subsequently, case reports of iris crystals in idiopathic chronic anterior uveitis (CAU), Fuch's heterochromic iridocyclitis, sarcoidosis-related CAU, human leukocyte antigen B27-associated CAU, panuveitis associated with pseudolymphoma, and their association with hypergammaglobulinemia were published. [2345678] We report one such case of a 38-year-old Indian female diagnosed as CAU with crystal deposition on iris as well as corneal endothelium and anterior lens capsule. Clinical features of the patient were documented over a period of 11 years (2006–2017).…”

Section: Introductionmentioning

confidence: 99%

Iris crystals: A rare clinical finding in chronic anterior uveitis

Mahendradas

Chauhan

Kawali

et al. 2019

Middle East Afr J Ophthalmol

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Iris crystals are a rare clinical entity seen in cases of chronic anterior uveitis (CAU). We report one such case with crystal deposition on iris as well as corneal endothelium and anterior lens capsule. No significant change in the crystals was seen over a period of 11 years despite multiple episodes of exacerbation and resolution. Anterior segment optical coherence tomography (AS-OCT) showed crystals as hyperreflective deposits over the corneal endothelium. On confocal microscopy, the crystals were seen as ill-defined hyperreflective lesions on endothelium between 525 and 604 μm. Reduction in the number of crystals was seen after cataract surgery. In conclusion, AS-OCT and confocal microscopy can be used as additional diagnostic tools to analyze iris crystals in CAU.

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Iris Crystals in Fuchs' Heterochromic Iridocyclitis

Cited by 13 publications

References 3 publications

Demystifying viral anterior uveitis: A review

Demystifying viral anterior uveitis: A review

Fuchs’ Uveitis Syndrome and Glaucoma

Iris crystals: A rare clinical finding in chronic anterior uveitis

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