Iris configuration in accommodation in pigment dispersion syndrome

Balidis, Miltos; Bunce, Catey; Sandy, Charles; Wormald, Richard; Miller, Michele

doi:10.1038/sj.eye.6700115

Cited by 17 publications

(6 citation statements)

References 12 publications

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“…In contrast, accommodative power declines with age, which may account for the burn‐out phase of PG. However, the effect of accommodation on iris profile in PDS/PG has been found to be highly variable, with some irides increasing in concavity, others remaining unchanged and some reducing in concavity 130 . The effect of accommodation on iris configuration is unlikely to be the sole factor in the aetiology of PDS.…”

Section: Risk Factors For Conversion From Pds To Pgmentioning

confidence: 96%

“…However, the effect of accommodation on iris profile in PDS/PG has been found to be highly variable, with some irides increasing in concavity, others remaining unchanged and some reducing in concavity. 130 The effect of accommodation on iris configuration is unlikely to be the sole factor in the aetiology of PDS. Pigment dispersion may depend on a number of factors that include the duration and degree of accommodation, pupil diameter and blinking.…”

Section: Accommodationmentioning

confidence: 99%

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Pigment dispersion syndrome and pigmentary glaucoma – a major review

Niyadurupola

Broadway

2008

Clinical Exper Ophthalmology

167

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Pigment dispersion syndrome (PDS) is an interesting condition that can lead to secondary open angle glaucoma. Pigmentary glaucoma is primarily a disease of young people, myopes and men. PDS is characterized by the presence of Krukenberg spindles, iris trans-illumination defects, trabecular meshwork pigmentation and backward bowing of the iris. Posterior bowing of the iris causes rubbing of the pigmented iris epithelium against lens structures, liberation of pigment and trabecular meshwork changes that result in reduced aqueous outflow with the risk of glaucoma. Peripheral laser iridotomy can reverse backward bowing of the iris and may prevent progression of pigmentary glaucoma.

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Section: Risk Factors For Conversion From Pds To Pgmentioning

confidence: 96%

Section: Accommodationmentioning

confidence: 99%

Pigment dispersion syndrome and pigmentary glaucoma – a major review

Niyadurupola

Broadway

2008

Clinical Exper Ophthalmology

167

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“…Thus, no morphological control of efficiency after PI could be performed. Accommodation, globe deformation caused by blinking, and physical exercise have been shown to increase iris concavity 1,34–36. These risk factors for an increase of IOP in PDS eyes decrease with age due to anatomical changes of the eye 1.…”

Section: Discussionmentioning

confidence: 99%

Anterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma

Klingenstein¹,

Kernt²,

Seidensticker³

et al. 2013

OPTH

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PurposeThe aim of the study reported here was to evaluate characteristics of the anterior-segment via anterior-segment optical coherence tomography (AS-OCT) and corneal biomechanical properties using an ocular response analyzer and their changes by peripheral laser iridotomy (PI) in patients with pigmentary glaucoma (PG).Materials and methodsSeventeen eyes with PG were included consecutively. AS-OCT and ocular response analyzer measurements were taken before and 3 months after PI. Baseline morphology and change in morphology were analyzed by correlation and multiple linear regression analysis. The main parameters assessed were anterior-chamber (AC) angles and volume as well as corneal hysteresis (CH) and corneal resistance factor.ResultsAC angles were found to have decreased significantly in each quadrant after PI (P<0.001), with the highest effect seen in the temporal quadrant, which decreased from 57.0°±9.6° to 44.1°±5.2° (± standard deviation). Mean AC volume decreased significantly from 213.1±36.4 to 187.0±23.4 mm3 (P<0.001). CH and corneal resistance factor did not change after PI. CH was found to correlate with the preoperative superior and inferior angle width (Spearman’s rho 0.553 and 0.615, respectively, P<0.05). Biomechanical parameters showed no predictive value on the change of AC angles or volume.ConclusionPI in eyes with PG results in a highly significant reduction in the AC angles and volume as visualized by AS-OCT, with the largest effect seen in the temporal quadrant. CH is strongly positively correlated with the superior and inferior preoperative AC angles, emphasizing the importance of the biomechanical properties of the cornea for glaucoma pathogenesis in PG, but corneal biomechanical properties cannot predict PI-related AC changes.

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“…It has been successfully used in the dynamic study of the angle structures of humans [1,9,11,12]. There have also been reports of the use of UBM for the imaging of the anterior segment in mice [5].…”

Section: Introductionmentioning

confidence: 99%