Iris Atrophy After Quinine Amblyopia

Knox, David L.; Palmer, C. A. L.; English, Frank P.

doi:10.1001/archopht.1966.03850010361010

Cited by 20 publications

(2 citation statements)

References 3 publications

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“…İris atrofisi kinin toksisitesinde sıklıkla geç bir bulgu olarak karşımıza çıkar. [22,23] OCT, erken ve geç dönemde kinin toksisitesini değerlendirmede önemli ipuçları verir. Erken dönemde iç retinal katlarda ödem geç dönemde ise atrofi gözlenir, dış retinal yapılar ise korunmuştur.…”

Section: Giriş 1 Kinin Sülfat Intoksikasyonuunclassified

Medications Damaging Ganglion Cell Layer or Optic Nerve: Pathogenesis, Diagnosis, and Treatment; (Quinine sulfate, Methanol, Carbon monoxide, Ritonavir, Fludarabine, Ethambutol, Methotrexate, Tamoxifen)

2023

Güncel Retina (Current Retina)

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The ocular system has dense vascularization and neural network. These structures may be exposed to the toxic effects of some systemically administered drugs. In addition, some factors that cause hypoxia by reducing oxygen transport due to high energy demand may cause different ocular problems. This article aimed to examine the effects of some drugs used systemically and some conditions leading to hypoxia that cause damage to the ganglion cell layer or optic nerve.

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Section: Giriş 1 Kinin Sülfat Intoksikasyonuunclassified

Medications Damaging Ganglion Cell Layer or Optic Nerve: Pathogenesis, Diagnosis, and Treatment; (Quinine sulfate, Methanol, Carbon monoxide, Ritonavir, Fludarabine, Ethambutol, Methotrexate, Tamoxifen)

2023

Güncel Retina (Current Retina)

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“…Acute poisoning with quinine resembles cinchonism and has been reported in accidental overdoses and in attempted suicides. 13,14 It is thought that quinine is toxic to the neurosensory retina and may mediate its effect through vasoconstriction. Late findings include optic atrophy, diffuse retinal vascular narrowing, and iris atrophy.…”

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confidence: 99%

Diagnostic and Therapeutic Challenges

Ussa¹,

Coco²,

Paulo³

et al. 2010

Retina

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A 79-year-old man was referred to our clinic with a diagnosis of retinitis pigmentosa (RP) and a 50-year history of decreased vision. He noticed vision impairment in both eyes at ;30 years of age. In his mid-40s, he lost central vision bilaterally. Five years ago, the right eye became amaurotic and in the left eye only the temporal field of vision remained. In his ocular history, the only relevant event was a lacrimal drainage system intervention. His medical history showed arterial hypertension and cardiac arrhythmia on treatment. Family history of eye disease was positive, having a sister with bilateral low vision, but the diagnosis and ophthalmic treatment were unknown by the patient.Examination showed visual acuity of no light perception in the right eye and hand movement perception in the temporal field of the left eye. Intraocular pressures were 38 mmHg in the right eye and 14 mmHg in the left eye. Central corneal ultrasonic pachymetry was 453 and 450 mm in his right and left eyes, respectively. External examination was unremarkable. At slit-lamp examination, he presented with bilateral iris stromal atrophy, mainly in the inferior quadrants with remaining tissue strands at the sphincter pupillae and iris periphery. There was superotemporal corectopia and nuclear cataracts in both eyes (Figures 1 and 2). Gonioscopy showed angle closure in the right eye (Shaffer grade 0) and occludable angles in the left eye (Shaffer grades 2-3). Fundus examination showed severe panretinal and choriocapillaris atrophy, vascular attenuation, and some peripheral subretinal pigmented deposits with exposition of scleral tissue in both eyes (Figure 3), also demonstrated on optical coherence tomography image. Small optic disks were noted with a cup-to-disk ratio of 1.0 in the right eye and 0.6 in the left eye. Optical coherence tomography of the anterior segment of the eye showed marked atrophy of the iris stroma ( Figure 4).

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Development and Significance of Heterochromia of the Iris

Gladstone¹

1969

Archives of Neurology

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Iris Atrophy After Quinine Amblyopia

Cited by 20 publications

References 3 publications

Medications Damaging Ganglion Cell Layer or Optic Nerve: Pathogenesis, Diagnosis, and Treatment; (Quinine sulfate, Methanol, Carbon monoxide, Ritonavir, Fludarabine, Ethambutol, Methotrexate, Tamoxifen)

Medications Damaging Ganglion Cell Layer or Optic Nerve: Pathogenesis, Diagnosis, and Treatment; (Quinine sulfate, Methanol, Carbon monoxide, Ritonavir, Fludarabine, Ethambutol, Methotrexate, Tamoxifen)

Diagnostic and Therapeutic Challenges

Development and Significance of Heterochromia of the Iris

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