Iriflophenone-3-C-glucoside from Cyclopia genistoides: Isolation and quantitative comparison of antioxidant capacity with mangiferin and isomangiferin using on-line HPLC antioxidant assays

Malherbe, Christiaan J.; Willenburg, Elize L.; Beer, Dalene de; Bonnet, Susan L.; Westhuizen, Jan H. van der; Joubert, Elizabeth

doi:10.1016/j.jchromb.2014.01.038

Cited by 34 publications

(26 citation statements)

References 23 publications

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“…Quercetin‐3‐ O ‐robinobioside was quantified as rutin equivalents due to unavailability of an authentic standard. Extracts of Cyclopia species (honeybush) were analysed by HPLC as described by de Beer and Joubert and Malherbe et al . Eriodictyol glucoside, phloretin‐3′,5′‐di‐ C ‐glucoside, iriflophenone‐3‐ C ‐glucoside and scolymoside were quantified as eriocitrin, phloretin‐3′‐ C ‐glucoside (nothofagin), hesperidin and luteolin equivalents, respectively.…”

Section: Methodsmentioning

confidence: 99%

The potential role of polyphenols in the modulation of skin cell viability byAspalathus linearisandCyclopiaspp. herbal tea extractsin vitro

Magcwebeba

Riedel

Swanevelder

et al. 2016

Journal of Pharmacy and Pharmacology

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Section: Methodsmentioning

confidence: 99%

The potential role of polyphenols in the modulation of skin cell viability byAspalathus linearisandCyclopiaspp. herbal tea extractsin vitro

Magcwebeba

Riedel

Swanevelder

et al. 2016

Journal of Pharmacy and Pharmacology

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“…A recent study compared the peroxyl radical activity of mangiferin with that of two other major polyphenols found in the unfermented extract of C. maculata used in this study i.e. isomangiferin and the benzophenone, iriflophenone-3-C-glucoside, showing the relative order of activity to be isomangiferin > mangiferin > iriflophenone-3-C-glucoside [15]. The unfermented extract used in this study has been characterised by Dudhia et al (l " Fig.…”

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confidence: 91%

Aqueous Extract of Unfermented Honeybush (Cyclopia maculata) Attenuates STZ-induced Diabetes and β-cell Cytotoxicity

et al. 2014

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New strategies, which include β-cell protection, are required in the treatment of T2D, as current drugs demonstrate little or no capacity to directly protect the vulnerable β-cell against diabetes-induced cytotoxicity. In this study we investigated the ameliorative effect of pre-treatment with an aqueous extract of unfermented Cyclopia maculata (honeybush) on STZ-induced diabetes and pancreatic β-cell cytotoxicity in Wistar rats after demonstrating a protective effect in vitro in RIN-5F cells. The amelioration of STZ-induced diabetes was seen in the reduction of the area under the curve, determined by the oral glucose tolerance test, as well as fasting glucose levels in extract-treated rats. Pre-treatment with extract also improved serum triglyceride levels and the glucose-to-insulin ratio. Pre-treatment with the extract or the drug, metformin, increased the β-cell area in islets, with a concomitant increase in β-cell proliferation at the higher extract dose (300 mg/kg/d), but not the lower dose (30 mg/kg/d). Subsequently, the in vitro tritiated thymidine incorporation assay showed that the extract was not mitogenic in RIN-5F cells. STZ-induced elevation of plasma nitrite levels was reduced in extract-treated rats, but no changes were observed in their serum catalase, serum glutathione, liver lipid peroxidation and liver nitrotyrosine levels. Pre-treating the rats with extract ameliorated the diabetic effect of STZ in Wistar rats, with evidence of pancreatic β-cells protection, attributed to the presence of high levels of antioxidants such as the xanthones, mangiferin and isomangiferin.

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“…This activity has been attributed to its content of ascorbic acid, carotenoids, and polyphenols, among them mangiferin, one of its most studied components (12)(13). It is a glucosylxanthone (2-b-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9Hxanthen-9-one), which is more abundant in the leaves and bark of Mangifera indica L (Anacardiaceae) and it can also be found in about sixteen plant families (14)(15).…”

Section: Introductionmentioning

confidence: 99%

“…Mangiferin has demonstrated antioxidant capacity in different in vitro studies, including a study in which it showed the ability to sequester DPPH and ABTS radicals (13). It has also shown a protective effect against oxidative stress in vivo in Wistar rats subjected to iron overload, where induced an increase in the activity of superoxide dismutase and glutathione peroxidase compared to the control group (16).…”

Section: Introductionmentioning

confidence: 99%

EFFECT OF MANGO (Mangifera indica) CV. AZÚCAR JUICE CONSUMPTION ON PLASMA ANTIOXIDANT CAPACITY AND OXIDATIVE STRESS BIOMARKERS

Zapata-Londoño

Ramos-Polo

Arbeláez

et al. 2020

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Background: Mango (Mangifera indica L.) is one of the world’s most consumed fruit, and it is also a rich source of antioxidants that may prevent oxidative stress. Objectives: This study aimed to determine if mango (cv. Azúcar) juice can improve the antioxidant status of healthy individuals with low consumption of vegetables and fruit. Methods: This was a cross-over single-blind study carried out with 16 healthy individuals for 73 days. Participants were randomly assigned to either a mango juice period or a placebo period. Total phenolic content, antioxidant capacity, mangiferin, thiobarbituric acid reactive substances (TBARS), total glutathione, and 8-hydroxydeoxyguanosine levels were determined in plasma. Results: Plasma antioxidant activity was significantly higher in the juice consumption period than the placebo consumption period; however, total phenolic content, total glutathione, TBARS, and 8-hydroxydeoxyguanosine levels did not show significant differences between juice period and placebo period. Mangiferin was detected in every participant after juice consumption. Conclusions: Mango (cv. Azúcar) juice daily consumption improves plasma antioxidant capacity.

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Iriflophenone-3-C-glucoside from Cyclopia genistoides: Isolation and quantitative comparison of antioxidant capacity with mangiferin and isomangiferin using on-line HPLC antioxidant assays

Cited by 34 publications

References 23 publications

The potential role of polyphenols in the modulation of skin cell viability byAspalathus linearisandCyclopiaspp. herbal tea extractsin vitro

The potential role of polyphenols in the modulation of skin cell viability byAspalathus linearisandCyclopiaspp. herbal tea extractsin vitro

Aqueous Extract of Unfermented Honeybush (Cyclopia maculata) Attenuates STZ-induced Diabetes and β-cell Cytotoxicity

EFFECT OF MANGO (Mangifera indica) CV. AZÚCAR JUICE CONSUMPTION ON PLASMA ANTIOXIDANT CAPACITY AND OXIDATIVE STRESS BIOMARKERS

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