Iridoids with anti-inflammatory effect from the aerial parts of Morinda officinalis How

Cai, Miaomiao; Liu, Mengyun; Chen, Pengxiao; Liu, Hong; Wang, Yifei; Yang, Dongzi; Zhao, Zhimin; Ding, Ping

doi:10.1016/j.fitote.2021.104991

Cited by 18 publications

(11 citation statements)

References 42 publications

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“…Similarly, officinaloside F (71.0 mg) and officinaloside G (56.0 mg) were obtained from fraction D. The chemical structures of compounds officinaloside A–G were mainly identified by nuclear magnetic resonance, mass spectrum, UV spectroscopy, and infrared absorption spectroscopy. The specific data shown in our previous article [ 15 ] and their structures are in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…20190731001) was deposited in the School of Pharmaceutical Science, Guangzhou University of Chinese Medicine. New iridoid compounds of officinaloside A–G were isolated from the aerial parts of MO as previously described [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…Various types of secondary metabolites have been identified in MO, including iridoids, anthraquinones, polysaccharides, oligosaccharides, and triterpenoids [ 14 ]. Previously we have isolated 16 iridoid compounds from the aerial parts of MO and elucidated their anti-inflammatory mechanisms [ 15 ]; herein, studies were carried out to investigate their anti-HSV-1 activity to maximize the utilization and development of the aerial parts of MO.…”

Section: Introductionmentioning

confidence: 99%

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Antiviral Activities of Officinaloside C against Herpes Simplex Virus-1

et al. 2022

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The iridoid compounds in traditional Chinese medicine play a prominent role in their antiviral effects. We previously reported the anti-inflammatory effect of new iridoids from the aerial parts of Morinda officinalis. Nevertheless, several open questions remain to explore the other biological functions of these new iridoid compounds. Herpes simplex virus-1 (HSV-1) is one of the most prevalent pathogens in human beings worldwide and due to limited therapies, mainly with the guanosine analog aciclovir (ACV) and other analogs, the search for new drugs with different modes of action and low toxicity becomes particularly urgent for public health. This study aimed to explore the anti-HSV-1 effects of iridoids from the aerial parts of Morinda officinalis. The dried aerial parts of Morinda officinalis were extracted with 95% ethanol and systematic separation and purification were then carried out by modern column chromatography methods such as silica gel column, RP-ODS column, Sephadex LH-20 gel column, and semi-preparative liquid phase, and the structure of these compounds were identified through the physical and chemical properties and a variety of spectral techniques. The obtained seven new iridoid compounds were screened for antiviral activity on HSV-1 through CCK8 and the cytopathic effect, and then the plaque reduction assay, the anti-fluorescence reporter virus strain replication, and RT-qPCR experiments were carried out to further evaluate the antiviral effect. Seven new iridoid compounds (officinaloside A–G) were identified from the aerial parts of Morinda officinalis, and officinaloside C showed anti-HSV-1 activity. Further functional experiments confirmed that officinaloside C has a significant inhibiting effect on HSV-1 virus plaque formation, viral gene, and protein expression, and fluorescent virus replication. Our findings suggest that officinaloside C has significant inhibitory effects on viral plaque formation, genome replication, and viral protein expression of HSV-1 which implies that officinaloside C exhibits viral activity and may be a promising treatment for HSV-1 infection.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antiviral Activities of Officinaloside C against Herpes Simplex Virus-1

et al. 2022

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“…Morinda officinalis How. is reported to exert an anti-inflammatory effect in rheumatoid arthritis, which mainly contributes to the iridoids in it [ 35 ]. In this study, the level of IL-1 β , IL-6 and TNF- α were increased in serum and uterine tissue of mice with adenomyosis compared to the controls, this funding was consist with the aforementioned results reported by others.…”

Section: Discussionmentioning

confidence: 99%

Qiu’s Neiyi Recipe Regulates the Inflammatory Action of Adenomyosis in Mice via the MAPK Signaling Pathway

Ying

Jiang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. The management of adenomyosis is challenging and limiting. Qiu’s Neiyi recipe (Qiu) is a traditional Chinese medicine (TCM) prescription clinically used for endometriosis treatment in China, but the effect and mechanism of Qiu on adenomyosis are undefined. Methods. An experimental adenomyosis model was induced in female neonatal ICR mice administrated with tamoxifen. The adenomyosis mice were divided into five groups: high-, middle-, and low-Qiu’s group, danazol group, and model group. The mice just administrated with the solvent only (no tamoxifen or drugs) were served as the control group. After 28 days of administration, the body, uterine, spleen, and thymus weights of all mice were examined. Then, the myometrial infiltration and the expression of inflammatory factors were detected by histology examination, ELISA, and qRT-PCR in the uterus. In addition, the MAPK/ERK signaling pathway-related protein expression in adenomyosis mice was detected by immunohistochemical (IHC) staining, qRT-PCR, and western blotting. Results. In experimental adenomyosis mice, Qiu treatment improved the symptoms of adenomyosis by reducing the myometrial infiltration and increasing the index of spleen and thymus. The elevated levels of IL-1β, IL-6, and TNF-α in serum and uterus tissues of adenomyosis model mice were also decreased after Qiu treatment. The improvement of Qiu on the adenomyosis was achieved by inhibiting the activated MAPK/ERK signaling pathway, including reducing the mRNA and protein expressions of p-ERK/ERK, p-JNK/JNK, and p-p38/p38 in the uterus tissues. Conclusion. Qiu alleviated the inflammatory reaction and uterus histological changes in mice with adenomyosis, and the potential mechanism is through the inhibition of the MAPK/ERK signaling pathway. Qiu may be a promising treatment for adenomyosis.

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“…Previous studies have suggested that oligosaccharides in MO can improve immunity, promote angiogenesis, enhance reproduction, and exert anti-osteoporosis, antioxidative, antidepressant, and antidementia effects ( Xu et al, 2017 ; Jiang et al, 2018 ; Chi et al, 2020 ; Zhu et al, 2019 ). The iridoids in MO have antioxidant, anti-chromosomal mutagenesis, antitumor, anti-inflammatory, and analgesic functions ( Choi et al, 2005 ; Zhang et al, 2020 ; Cai et al, 2021 ). Furthermore, palmitic acid and succinic acid present in MO have antidepressant effects ( Cui et al, 1995 ; Zhu et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer’s disease

Zhang

2022

Front. Aging Neurosci.

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Pharmacological studies have shown that some traditional Chinese medicines (TCMs) have applications in the treatment of Alzheimer’s disease (AD). Morinda officinalis How. (MO) is a TCM with a long history and is widely used to tonify kidney Yang. In vitro and in vivo experiments have suggested that MO contains various effective pharmaceutical components and chemicals, including oligosaccharides, anthraquinones, iridoids, flavonoids, amino acids, and trace elements, conferring MO with anti-inflammatory and antioxidant properties. Neuroinflammation and oxidative stress are undoubtedly hallmarks of neurodegeneration, contributing to AD progression. In this mini-review, we summarize the molecular mechanisms, structure-activity relationships, and potential synergistic and antagonistic effects of active components in MO. This discussion highlights the roles of these active components, such as oligosaccharides, anthraquinones, and iridoid glycosides, in the treatment of AD via anti-inflammatory and antioxidant mechanisms, providing a scientific basis for further utilization of MO.

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Iridoids with anti-inflammatory effect from the aerial parts of Morinda officinalis How

Cited by 18 publications

References 42 publications

Antiviral Activities of Officinaloside C against Herpes Simplex Virus-1

Antiviral Activities of Officinaloside C against Herpes Simplex Virus-1

Qiu’s Neiyi Recipe Regulates the Inflammatory Action of Adenomyosis in Mice via the MAPK Signaling Pathway

Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer’s disease

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