Iridocyclectomy for Melanomas of the Ciliary Body: A Follow-Up Study of Pathology and Surgical Morbidity

Forrest, Arnold W.; Keyser, Robert B.; Spencer, William H.

doi:10.1016/s0161-6420(78)35560-3

Cited by 30 publications

(13 citation statements)

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“…UM recurrence rates up to 15% after radiation therapy (including plaques and proton beam therapy) have been reported [2, 4, 5, 6, 7]. With local resection, Shields et al [8]have reported an 11% recurrence rate for ciliary body and choroidal tumours, and for iris melanomas, we found that recurrence rates of 8–11% have been reported [9, 10]. For melanomas confined to the choroid, a 32% recurrence rate after local resection has recently been reported by Damato et al [11].…”

Section: Introductionsupporting

confidence: 55%

Biomolecular Markers of Malignancy in Human Uveal Melanoma: The Role of the Cadherin-Catenin Complex and Gene Expression Profiling

et al. 2003

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In recent years there has been a trend towards conservative management of uveal melanoma (UM), aimed at preserving the eye and vision. Despite improvements with this approach, recurrent tumour and metastatic disease still occur, and the management remains problematic. As a result of these limitations, there is interest in gaining a greater understanding of molecular changes associated with aggressive disease patterns in UM. This might result in new, more effective and less toxic therapies as well as provide prognostic information for defining subgroups of patients with a less favourable prognosis as potential candidates for adjuvant therapies. Accumulating evidence over the past decade suggests that disturbance in the cadherin-catenin adhesion complex is critical in the process leading to invasion and metastasis of many cancers. The recent advent of DNA micro-array technology now offers an unprecedented ability to study these molecules and others associated with malignant transformation. In this mini-review, the aspects of tumour progression in which cadherin-catenin may be involved are dealt with along with the potential application of DNA micro-array technology to the problem in UM.

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Section: Introductionsupporting

confidence: 55%

Biomolecular Markers of Malignancy in Human Uveal Melanoma: The Role of the Cadherin-Catenin Complex and Gene Expression Profiling

et al. 2003

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“…Forrest et al [5] noted that 48% of predom inantly ciliary body melanomas were of spindle A cell type. Other pigmented lesions that can involve the ciliary body include magnocellular nevi,nevi, tumors of the pigmented ciliary epi thelium and more malignant cell types of mela nomas.…”

Section: Discussionmentioning

confidence: 99%

Fluorescein Angiography in Ciliary Body Melanomas

Fries¹,

Char

1990

Ophthalmologica

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“…The ciliary body region is a readily accessible region of the eye using several techniques [28,29]. Access to ciliary body tissue for tumor biopsy is well established [30], and recently, one group described a technique to culture ciliary body cells from human patients using minimal tissue [31].…”

Section: Fig 4 Endogenous Expression Of Reprogramming Factors In Wimentioning

confidence: 99%

Facile and Efficient Reprogramming of Ciliary Body Epithelial Cells into Induced Pluripotent Stem Cells

Nakanishi

et al. 2013

Stem Cells and Development

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Induced pluripotent stem (iPS) cells are attractive for cell replacement therapy, because they overcome ethical and immune rejection issues that are associated with embryonic stem cells. iPS cells have been derived from autonomous fibroblasts at low efficiency using multiple ectopic transcription factors. Recent evidence suggests that the epigenome of donor cell sources plays an important role in the reprogramming and differentiation characteristics of iPS cells. Thus, identification of somatic cell types that are easily accessible and are more amenable for cellular reprogramming is critical for regenerative medicine applications. Here, we identify ciliary body epithelial cells (CECs) as a new cell type for iPS cell generation that has higher reprogramming efficiency compared with fibroblasts. The ciliary body is composed of epithelial cells that are located in the anterior portion of the eye at the level of the lens and is readily surgically accessible. CECs also have a reduced reprogramming requirement, as we demonstrate that ectopic Sox2 and c-Myc are dispensable. Enhanced reprogramming efficiency may be due to increased basal levels of Sox2 in CECs. In addition, we are the first to report a cellular reprogramming haploinsufficiency observed when reprogramming with fewer factors (Oct4 and Klf4) in Sox2 hemizygous cells. Taken together, endogenous Sox2 levels are critical for the enhanced efficiency and reduced exogenous requirement that permit facile cellular reprogramming of CECs.

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Iridocyclectomy for Melanomas of the Ciliary Body: A Follow-Up Study of Pathology and Surgical Morbidity

Cited by 30 publications

References 1 publication

Biomolecular Markers of Malignancy in Human Uveal Melanoma: The Role of the Cadherin-Catenin Complex and Gene Expression Profiling

Biomolecular Markers of Malignancy in Human Uveal Melanoma: The Role of the Cadherin-Catenin Complex and Gene Expression Profiling

Fluorescein Angiography in Ciliary Body Melanomas

Facile and Efficient Reprogramming of Ciliary Body Epithelial Cells into Induced Pluripotent Stem Cells

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