Iridociliary Epithelial Tumors

Peiffer, Robert L.; Riis, Ronald C.; Clerc, Bernar

doi:10.1002/9780470376904.ch6

Ocular Tumors in Animals and Humans 2002

DOI: 10.1002/9780470376904.ch6

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Iridociliary Epithelial Tumors

Robert L. Peiffer¹,

Ronald C. Riis²,

Bernar Clerc³

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Cited by 2 publications

(12 citation statements)

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“…"content-markup(./author-grp [1]/aff|./author-grp [1]/dept-list)> Medulloepitheliomas are rare primitive neuroepithelial tumors. 13 In animals, most intraocular medulloepitheliomas are described in horses, 7,14,16,17 and only rare case reports exist in dogs, 2,18 cats, 12 and cockatiels. 3,15 They are classified as nonteratoid and teratoid and can be benign or malignant.…”

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“…3,15 They are classified as nonteratoid and teratoid and can be benign or malignant. 6,10,13,16 Nonteratoid ocular medulloepitheliomas are composed only of undifferentiated neuroepithelium, while teratoid ocular medulloepitheliomas contain additional heteroplastic components such as cartilage or brain tissue. 10,13,16 This report describes a nonteratoid ocular medulloepithelioma in a llama with widespread metastasis to regional lymph nodes and internal organs.…”

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Malignant Nonteratoid Ocular Medulloepithelioma in a Llama (Llama Glama)

2006

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Abstract. A 6-year-old female llama presented with buphthalmos of its right eye owing to the presence of an intraocular mass. The affected globe was enucleated and submitted for microscopic examination. The intraocular mass was diagnosed as malignant medulloepithelioma. Within the following months, the llama developed soft tissue masses, which completely filled the right orbital cavity and expanded the cranial portion of the right mandibular bone, and enlarged mandibular lymph nodes. Euthanasia was elected 30 months after the initial diagnosis. The carcass was submitted for postmortem examination, which revealed the presence of medulloepithelioma metastases within the right orbit, mandible, mandibular lymph nodes, lungs, liver, and mesenteric and sublumbar lymph nodes. The primary intraocular tumor and its metastases were composed of neoplastic undifferentiated neuroepithelial cells, which formed tubules, Flexner-Wintersteiner and Homer Wright rosettes, and rare solid sheets. Electron microscopy showed that tumor cells were connected by desmosome-like junctions and contained rare intracytoplasmic basal bodies. Neoplastic cells were positive for vimentin, nestin, microtubule-associated protein 1B, S-100 protein, and glial fibrillary acidic protein (GFAP).

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Malignant Nonteratoid Ocular Medulloepithelioma in a Llama (Llama Glama)

2006

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“…30 The present study describes the histomorphological and immunohistochemical features of a spontaneous intraocular tumor suggestive of a glioneuroma with medulloepitheliomatous differentiation in an adult goldfish (Carassius auratus).Glioneuroma and medulloepithelioma may arise from either the outer or the inner layer of the optic cup and from primitive medulloepithelium. 24 It is generally thought that medulloepithelioma is a true neoplasm originating from developing embryonal retinal cells, while glioneuroma is regarded as a choristomatous malformation consisting of glial and neuronal cells without obvious neoplastic potential. 14 An adult female goldfish living in a 50-liter hobbyist aquarium was presented with unilateral progressive exophthalmos of the left eye.…”

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“…Glioneuroma and medulloepithelioma may arise from either the outer or the inner layer of the optic cup and from primitive medulloepithelium. 24 It is generally thought that medulloepithelioma is a true neoplasm originating from developing embryonal retinal cells, while glioneuroma is regarded as a choristomatous malformation consisting of glial and neuronal cells without obvious neoplastic potential. 14…”

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confidence: 99%

“…24 It is generally thought that medulloepithelioma is a true neoplasm originating from developing embryonal retinal cells, while glioneuroma is regarded as a choristomatous malformation consisting of glial and neuronal cells without obvious neoplastic potential. 14 An adult female goldfish living in a 50-liter hobbyist aquarium was presented with unilateral progressive exophthalmos of the left eye.…”

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Ocular glioneuroma with medulloepitheliomatous differentiation in a goldfish (Carassius auratus)

et al. 2014

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Brief communicationSpontaneous ocular tumors arising from the retina are rare in fish. Reported lesions include adenocarcinoma of the retinal pigment epithelium in a guppy (Poecilia reticulata) and retinoblastoma in a spring cavefish (Forbesichthys agassizii; syn. Chologaster agassizi), porkfish (Anisotremus virginicus), and brown bullhead (Ameiurus nebulosus; syn. Ictalurus nebulosus).9,10,27 Two medulloepithelioma have been described in a goldfish (Carassius auratus) 17 and in a tinfoil barb (Barbonymus schwanenfeldii; syn. Barbodes subwanefeldi).13 Among other primitive ocular neoplasms with an ectodermic origin, a primitive neuroectodermal tumor was reported in a telescope goldfish. 3In veterinary medicine, there are no reports of glioneuroma to the authors' knowledge. This rare congenital embryonic tumor is reported in pediatric or young human patients. 1,14,19,31 Medulloepithelioma is a very rare tumor in dogs 2,8,15,26 and horses, 18 and is extremely rare in cats. 12 Isolated cases have been reported in other species, including birds 5 and llamas. 30 The present study describes the histomorphological and immunohistochemical features of a spontaneous intraocular tumor suggestive of a glioneuroma with medulloepitheliomatous differentiation in an adult goldfish (Carassius auratus).Glioneuroma and medulloepithelioma may arise from either the outer or the inner layer of the optic cup and from primitive medulloepithelium. 24 It is generally thought that medulloepithelioma is a true neoplasm originating from developing embryonal retinal cells, while glioneuroma is regarded as a choristomatous malformation consisting of glial and neuronal cells without obvious neoplastic potential. 14 An adult female goldfish living in a 50-liter hobbyist aquarium was presented with unilateral progressive exophthalmos of the left eye. While the animal's body condition deteriorated and the left eye continually enlarged, the fish maintained an appropriate body position in the water column for the several months prior to death. Only a few days before death, the fish listed to the left and its head dragged along the bottom. The right eye was normal in size and had a red pigmentation of the limbus. Neither medical treatment of the eye nor disinfection of the aquarium was carried out. The fish shared the aquarium with another goldfish found dead with gross and microscopic lesions of mycobacteriosis. Abstract. An intraocular mass in the left eye causing chronic severe exophthalmia in an adult female goldfish (Carassius auratus) is described. The fish shared an aquarium with another goldfish found dead with gross and microscopic lesions consistent with mycobacteriosis. Histological examination of the left eye, histochemical (periodic acid-Schiff [PAS], Alcian blue, Ziehl-Neelsen) and immunohistochemical tests (glial fibrillary acidic protein, human neuronal protein, vimentin, and cytokeratin AE1/AE3) were carried out on the intraocular mass. Neoplastic cells forming an unencapsulated highly cellular proliferation partially covered by a...

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Iridociliary Epithelial Tumors

Cited by 2 publications

References 74 publications

Malignant Nonteratoid Ocular Medulloepithelioma in a Llama (Llama Glama)

Malignant Nonteratoid Ocular Medulloepithelioma in a Llama (Llama Glama)

Ocular glioneuroma with medulloepitheliomatous differentiation in a goldfish (Carassius auratus)

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