Iridium(III) carbene complexes as potent girdin inhibitors against metastatic cancers
Mei-Ling Ruan,
Wen-Xiu Ni,
Jacky C. H. Chu
et al.
Abstract:Many cancer-driving protein targets remain undruggable due to a lack of binding molecular scaffolds. In this regard, octahedral metal complexes with unique and versatile three-dimensional structures have rarely been explored as inhibitors of undruggable protein targets. Here, we describe antitumor iridium(III) pyridinium-N-heterocyclic carbene complex
1a
, which profoundly reduces the viability of lung and breast cancer cells as well as cancer patient-derived organoids at low micromolar… Show more
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