Iridium‐Complex‐Functionalized Fe3O4/SiO2 Core/Shell Nanoparticles: A Facile Three‐in‐One System in Magnetic Resonance Imaging, Luminescence Imaging, and Photodynamic Therapy

Lai, Chih‐Wei; Wang, Yu‐Hsiu; Lai, Cheng Hsuan; Yang, Meng Ju; Chen, Chun‐Yen; Chou, Pi‐Tai; Chan, Chi Shun; Chi, Yun; Chen, Yi Chun; Hsiao, Jong‐Kai

doi:10.1002/smll.200700283

Cited by 227 publications

(121 citation statements)

References 41 publications

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“…Such photosensitizers are luminescent dyes that use the energy of light to transform non-toxic 3 O 2 to a toxic, reactive oxygen species. Frequently, research groups report on the incorporation of photosensitizers into magnetic particles [8,18,19,26,28,97,146]. Such particles allow targeted PDT and limit damages to healthy tissue.…”

Section: Cancer Therapymentioning

confidence: 98%

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Luminescent magnetic particles: structures, syntheses, multimodal imaging, and analytical applications

Mistlberger

Klimant

2010

Bioanal Rev

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Luminescent magnetic particles (LuMaPs) are attractive tools for life science applications such as multimodal imaging, analyte monitoring, nanotherapeutics, and combinations thereof. LuMaPs consist of at least one magnetic and one luminescent component which often are incorporated in a (polymeric) matrix. A large variety of materials do exist for the components that make up LuMaPs. However, a smart selection and combination is required for achieving useful tools. While the magnetic component mainly influences the response to a magnetic field, the luminophore can act as label, sensor, or therapeutic agent. The matrix fulfills tasks such as stabilizing the luminophore and magnet, carrying useful functional groups on its surface, or hosting smart drug delivery systems. Surface modifications with targeting ligands can further improve the applicability of LuMaPs, for example in biomedicine. This review provides an overview on LuMaPs with respect to the materials used and to its structures. Routes toward LuMaPs are outlined, and potential applications are discussed.

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Section: Cancer Therapymentioning

confidence: 98%

“…Dye-based LuMaPs were applied as optical chemical oxygen sensors [10, 11, 24-26, 92, 93], pH sensors [10-12, 26, 47, 93], and photodynamic therapy agents [8,18,19,26,28,97,146]. These applications are discussed in "Applications of LuMaPs".…”

Section: Luminescent Moleculesmentioning

confidence: 99%

Luminescent magnetic particles: structures, syntheses, multimodal imaging, and analytical applications

Mistlberger

Klimant

2010

Bioanal Rev

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“…Hsiao and collaborators reported the synthesis of a multifunctional nanomaterial conjugating a functionalized iridium complex with a Fe 3 O 4 /SiO 2 core/shell nanocomposite (Lai et al 2008). The magnetic core provides capability for MRI.…”

Section: Covalent Encapsulation Of Ps In Silica Nanoparticlesmentioning

confidence: 99%

“…Most of the studies with nanosystems have been carried out in vitro, but in vivo PDT is currently being investigated ). Another field which grows rapidly consists in combining several applications within one nano-object, such as MRI, fluorescence imaging and PDT (Tada et al 2007;Lai et al 2008;Liu et al 2008a). Such multifunctional nanoparticles emerge as important theranostic nano-objects.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles for Photodynamic Therapy Applications

Vanderesse

Frochot

Barberi‐Heyob

et al. 2011

Intracellular Delivery

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Photodynamic therapy has emerged as an alternative to chemo-and radiotherapy for the treatment of certain types of cancer. Nanoparticles have been used to improve the delivery and the efficiency of the photosensitizer as they allow its encapsulation without loss of activity. Using targeting strategies, they can also allow the selective accumulation of the photosensitizer in the cancer tissues. In this review, based on the chemical nature of the nanoparticles, the different methods for their syntheses are described from the pioneering works to the latest achievements. Indeed the nanosystems can be conjugated to a biomolecule or an antibody to target receptors over-expressed in cancer cells and/or angiogenic vascular endothelial cells. Numerous in vivo and in vitro applications have been described. Multifunctional nanoplatforms combining several applications within the same nano-object emerge as potential important theranostic tools.

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“…For example, a magnetic core coated with a phosphorescent shell provides the capability for dual-mode MRI and phosphorescence imaging. Core-shell nanoparticles have been constructed with magnetic Fe 3 O 4 as the core and SiO 2 as the shell [98]. The latter has been functionalized with a phosphorescent iridium(III) complex 131.…”

Section: Phosphorescence and Magnetic Resonance Multi-mode Imagingmentioning

confidence: 99%

Phosphorescent Iridium(III) Complexes for Bioimaging

Zhang

Liu

Zhao

et al. 2014

Luminescent and Photoactive Transition Metal Complexes as Biomolecular Probes and Cellular Reagents

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Phosphorescent iridium(III) complexes have received increasing attention in bioimaging applications owing to their advantageous photophysical properties and efficient internalization into live cells. In this chapter, we summarize the recent design of bioimaging reagents based on phosphorescent iridium(III) complexes. The utilizations of cationic, neutral, and zwitterionic phosphorescent iridium(III) complexes in bioimaging applications have been described first.Complexes showing aggregation-induced phosphorescence have also been included considering the absence of the commonly observed aggregation-caused quenching. Then we discuss the functionalization of iridium(III) complexes with biological substrates and reactive groups, which allows non-covalent and covalent interaction, respectively, with intracellular biomolecules. As the photophysical properties of iridium(III) complexes are very sensitive toward their surrounding ligands and microenvironment, the use of these complexes as intracellular sensors for gas molecules, ions, and amino acids has been summarized. Additionally, the incorporation of iridium(III) complexes into dendrimer, polymer, and nanoparticle systems providing attractive functionalities has been discussed. Furthermore, various strategies, including the use of near-infrared-emitting and two-photon excitable complexes, upconversion nanoparticles, and lifetime-based microscopy techniques, to enhance signal-to-noise ratios in bioimaging have been discussed. At last, the design of reagents for multi-mode imaging techniques involving phosphorescence and magnetic resonance imaging has been described.

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Iridium‐Complex‐Functionalized Fe₃O₄/SiO₂ Core/Shell Nanoparticles: A Facile Three‐in‐One System in Magnetic Resonance Imaging, Luminescence Imaging, and Photodynamic Therapy

Cited by 227 publications

References 41 publications

Luminescent magnetic particles: structures, syntheses, multimodal imaging, and analytical applications

Luminescent magnetic particles: structures, syntheses, multimodal imaging, and analytical applications

Nanoparticles for Photodynamic Therapy Applications

Phosphorescent Iridium(III) Complexes for Bioimaging

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