Iridium-catalyzed reductive amination of carboxylic acids

Catalytic One‐Pot Reductive Amination of Carboxylic Acids

“…In 2023, with their iridium catalysts, Luo and Yang developed an efficient and general method for reductive amination of diverse carboxylic acids, enabling the synthesis of diverse secondary and tertiary amines (Scheme 15). [35] The transformation showed excellent compatibility with different substituents on secondary amines. N ‐Allyl substituted amines were selectively methylated, and hydroxyethyl and cyano groups were well‐tolerated ( 71 , 72 , 109 ).…”

Iridium-catalyzed reductive γ-lactonization of ortho-acylbenzoic acids in water: sustainable access to phthalides

“…In addition, changing the pyridyl ring to quinolinyl or replacing the iridium metal with rhodium or ruthenium all led to failure of the reductive lactonization (entries [10][11][12]. Several rare earth metal catalysts (C13-C16) and cobalt catalyst C17 with a tridentate ligand [2,6bis(4,5-dihydro-1H-imidazol-2-yl)pyridine] were also tried; however, all of them showed no activity (entries [13][14][15][16][17]. With the C2 catalyst, we optimized the amount of formic acid (entries [18][19][20][21][22][23][24][25].…”

“…They still display high reducing ability even in the presence of a considerable amount of sulphuric acid 11j or p-toluenesulfonic acid. 17 Our expertise supplies us with a feasible solution to the challenging problems in the envisioned reduction lactonization protocol. With these iridium catalysts in hand, we achieved the iridium-catalyzed reductive lactonization of 2-acylbenzoic acids (Scheme 1b).…”

Recent advances of Cp*Ir complexes for transfer hydrogenation: focus on formic acid/formate as hydrogen donors

“…Very recently, we reported a procedure for reductive amination of amines and carboxylic acids (Scheme 30). 75 Apparently, amides are demonstrated as intermediates via condensation of amines and carboxylic acids through control experiments. Using this catalytic system, a variety of N-alkylated amines were obtained via the reduction amination of carboxylic acids under mild reaction conditions.…”