Iridium‐catalyzed asymmetric hydrogenation of β‐ketophosphonates with chiral ferrocenyl P,N,N‐ligands

Abstract

The asymmetric hydrogenation of β‐ketophosphonates with chiral Ir/P,N,N‐ligands catalyst has been developed. A series of β‐ketophosphonates were hydrogenated, and the corresponding β‐hydroxyphosphonates were obtained in high yields with good or excellent enantioselectivities under mild condition.

New P,Nsp3ligands for palladium-catalyzed asymmetric allylic substitutions

“…21 Based on our recent work in asymmetric catalysis, we envisioned that the introduction of an additional chiral center in ligand L1 might lead to more space restriction and enhance chiral control of the metal catalyst, which will give better catalytic reactivity and enantioselectivity. 20 Thus, new P,N sp3 ligands L2a–d were designed and synthesized.…”

“…Strategies to improve the enantioselectivity included either tuning of the ligand backbone and substituents or introducing extra chiral centers. Based on our previous work in asymmetric catalysis with ( ortho -diphenylphosphino)benzylamino backbone ligands, 19 herein we would like to report a new P,N sp3 ligand of this backbone with an additional chiral center 20 and its application in palladium-catalyzed AAS for the formation of C–C, C–N and C–O bonds.…”