Iridal-type triterpenoids with anti-HBV activity from Iris confusa

Chen, Xinglong; Zhang, Xiuqiong; Ma, Yun‐Bao; Deng, Zhen-Tao; Geng, Chang‐An

doi:10.1016/j.fitote.2018.06.005

Cited by 8 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They also have economical value as iris oil is one of the most precious ingredients in perfumery 30–32 . Not only is the genus Iris of ornamental and economic value, but it has also been shown to have several interesting biological activities including anti‐inflammatory, antimicrobial, antioxidant, phytoestrogenic, antidiabetic, hepatoprotective, antihepatitis B, anticholinesterase, anti‐plasmodial, molluscicidal, antimicrobial, antineoplastic and cytotoxic activities 12,33–38 …”

Section: Discussionmentioning

confidence: 99%

“…Irises have been medicinally used since the Ancient Egyptians as evidence has been found engraved on a marble panel in a temple at Karnak 9–11 . Iris confusa rhizomes have been in Chinese folk medicine to treat acute tonsillitis and bronchitis 12 . Iris pseudacorus and I. germanica rhizomes have been used as a diuretic, carminative and against constipation and stomachache in Anatolian folk medicine 13 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Discrimination of common Iris species from Egypt based on their genetic and metabolic profiling

Okba

Abdel-Baki

Khaleel

et al. 2020

Phytochemical Analysis

View full text Add to dashboard Cite

Introduction Irises have been medicinally used in Ancient Egyptians, Anatolian, Chinese, British and Irish folk medicine. They are also well‐known ornamental plants that have economic value in the perfume industry. The main obvious diagnostic difference between the different species is based on the morphology of the flowers. The flowering cycle is very short as well as the persistence of the fully opened flowers extends for a few days only. Moreover, the climatic conditions significantly causes fluctuation in their blooming time from year to year. This makes the morphological discrimination very difficult. The discrimination of different iris species is of a great importance, as each species is reported to possess different folk medicinal activities. Objectives Finding genetic and metabolic markers for differentiation between Iris confusa Sealy (Subgen. Limniris Sect. Lophiris), I. pseudacorus L. (Subgen. Limniris Sect. Limniris) and I. germanica L. (Subgen. Iris Sect. Iris) on levels other than traditional taxonomic features. Material and Methods Inter‐simple sequence repeat (ISSR) and gas chromatography–mass spectrometry (GC–MS) analyses were performed. Results The highest similarity was found between I. pseudacorus L. and I. germanica L. and the least similarity was between I. confusa Sealy and I. pseudacorus L. The metabolic profiling of the leaves confirmed genetic profiling discriminating I. confusa from the other two species. The primary metabolites of the underground parts showed clear discrimination between the three species. Conclusions This study represents the sole complete map for distinguishing the three Iris species on genetic and metabolic bases.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Discrimination of common Iris species from Egypt based on their genetic and metabolic profiling

Okba

Abdel-Baki

Khaleel

et al. 2020

Phytochemical Analysis

View full text Add to dashboard Cite

show abstract

“…At the same time Iris L. is promising in medicine. Iris L. has been used in traditional medicine in China, India and Europe for the treatment of bacterial, inflammation, cancer and viral diseases 2–5 . The extracts of Iris L. are known for its antioxidant, antibacterial, antiviral, anti‐inflammatory, antitumor, hepatoprotective, hypolipidemic, and immunomodulatory properties.…”

Section: Introductionmentioning

confidence: 99%

Development of approach for flavonoid profiling of biotechnological raw materials Iris sibirica L. by HPLC with high‐resolution tandem mass spectrometry

Karpitskiy

Бессонова

Карцова

et al. 2022

Phytochemical Analysis

View full text Add to dashboard Cite

Introduction Iris L. are promising in medicine due to the biological activity of extracts. Iris sibirica L. is spread in Russia but its phytochemical composition has not been studied in detail though it is included in the Red Book. For this reason, I. sibirica L. biotechnology is in high demand. One of the key points in biotechnology is the regulation of plant metabolism using phytohormones. Obtaining of chromatographic metabolite profiles allows to control this process. Objective The aim of this study was to develop an approach for effective control of biotechnological raw materials of I. sibirica L. by flavonoid profiles using high‐performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) and to investigate the influence of phytohormones in nutrient media on content of flavonoids. Methodology Iris sibirica L. regenerated plants were grown on Murashige–Skoog media with 6‐benzylaminopurine (6‐BAP) and α‐naphtylacetic acid (NAA) additives. To optimise extraction conditions, the design of the experiment was used. Profiles of polyphenols were obtained by HPLC–MS/MS in the positive and negative ionisation modes. Results The process for efficient extraction from leaves of I. sibirica L. were developed. The factors influencing the extraction efficiency of flavonoids have been determined. A total of 36 compounds were identified by HPLC–MS/MS. Among them isoflavones and their glycosides are the main classes. Addition of an auxin‐like hormone increased the non‐polar flavonoid levels, but decreased the polar ones. The variation in concentration of cytokinin (6‐BAP) affected almost all of the analytes. Conclusion The methodology for effective control of I. sibirica L. raw plant material biotechnology was developed by analysing obtained chromatographic polyphenol profiles.

show abstract

“…Reviewing the current literature, very few reports were traced concerning I. confusa Sealy (bamboo iris) phytochemical constituents 29 , 34 . In addition, nothing was traced about the biological activity of its isolated compounds except the study conducted by Chen et al 2018 who studied their anti- hepatitis B potential 34 . In a continuation of our interest in exploring irises metabolites and their possible activities 35 , I. confusa was selected for this study.…”

Section: Introductionmentioning

confidence: 99%

Irigenin, a novel lead from Iris confusa for management of Helicobacter pylori infection with selective COX-2 and HpIMPDH inhibitory potential

Abdel-Baki

El‐Sherei

Khaleel

et al. 2022

Sci Rep

View full text Add to dashboard Cite

The development of new natural drugs for Helicobacter pylori (H. pylori) management has recently received significant attention. Iris confusa (I. confusa) was long used for the treatment of bacterial infections and gastritis. This study aimed at evaluating its effect on management of H. pylori infection and exploring its bioactive metabolites. The inhibitory potential of the polar (PF), non-polar (NPF) fractions and the isolated compounds against H. pylori using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay in addition to their cyclooxygenases (COX-1 and COX-2), and nitric oxide (NO) inhibitory activities were assessed. The most biologically active compound was tested for its selective H. pylori inosine-5′-monophosphate dehydrogenase (HpIMPDH) inhibitory potential. Chromatographic purification of PF and NPF allowed isolation of tectoridin, orientin, irigenin, tectorigenin, isoarborinol and stigmasterol. The PF exhibited significant anti-H. pylori (MIC 62.50 µg/mL), COX-1, COX-2 (IC50 of 112.08 ± 0.60 and 47.90 ± 1.50 µg/mL respectively, selectivity index SI of 2.34), and NO (IC50 47.80 ± 0.89 µg/mL) inhibitory activities, while irigenin was the most potent isolated compound. Irigenin was found to have a promising activity against HpIMPDH enzyme (IC50 of 2.07 ± 1.90 μM) with low activity against human hIMPDH2 (IC50 > 10 μM) than clarithromycin, assuring its selectivity. Overall, I. confusa and its isolated compounds may serve as a potential source of plant-based drugs for H. pylori control. This study scientifically validated the claimed anti-bacterial activity of I. confusa and revealed irigenin potential as a novel lead exhibiting anti H. pylori activity in a first record.

show abstract

Iridal-type triterpenoids with anti-HBV activity from Iris confusa

Cited by 8 publications

References 24 publications

Discrimination of common Iris species from Egypt based on their genetic and metabolic profiling

Discrimination of common Iris species from Egypt based on their genetic and metabolic profiling

Development of approach for flavonoid profiling of biotechnological raw materials Iris sibirica L. by HPLC with high‐resolution tandem mass spectrometry

Irigenin, a novel lead from Iris confusa for management of Helicobacter pylori infection with selective COX-2 and HpIMPDH inhibitory potential

Contact Info

Product

Resources

About