Irbesartan decreased mitochondrial stress related apoptosis in cisplatin induced acute kidney injury via regulating BCL-2/BAX signaling

İlhan, İlter; Aşçı, Halil; Hasseyid, Nursel; DOĞAN, Hatice Kübra; Ağirca, Şerife; ALTINTAŞ, Melike; Tepebaşı, Muhammet Yusuf

doi:10.1007/s11033-022-07403-3

Cited by 6 publications

(2 citation statements)

References 43 publications

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“…Studies have shown that the degree of cell damage can be reduced by regulating the expression balance of Bcl-2 and Bax. 56 The results of this study showed that gavage of OVT could prevent gastric mucosal damage, which could remarkably enhance mRNA and protein expression of Bcl-2 and significantly decrease mRNA and protein expression of Bax, and OVT could regulate the balance of both and inhibit the occurrence of apoptosis. In conclusion, OVT may protect gastric mucosa by regulating apoptosis.…”

Section: Discussionmentioning

confidence: 72%

Ovotransferrin alleviated acute gastric mucosal injury in BALB/c mice caused by ethanol

et al. 2023

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Section: Discussionmentioning

confidence: 72%

Ovotransferrin alleviated acute gastric mucosal injury in BALB/c mice caused by ethanol

et al. 2023

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“…The TAS and TOS levels were determined using Erel's colorimetric method on supernatants collected after homogenization using an automated analyzer (Beckman Coulter, USA). Then, the OSI value was determined by calculating OSI=[(TOS, μmol/L)/(TAS, mmol Trolox eq/L)x100] 12 .…”

Section: Methodsmentioning

confidence: 99%

miR-21, miR-221, and miR-222 upregulation in lung cancer promotes metastasis by reducing oxidative stress and apoptosis

Tepebaşı

Öztürk

2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The purpose of our research was to observe the effects of miR-21, miR-221, and miR-222, as well as their target genes on oxidative stress, lung cancer formation, and metastasis. METHODS: Positron emission tomography/computed tomography, fiberoptic bronchoscopy, and/or endobronchial ultrasonography were performed on a total of 69 lung cancer patients to detect the presence or absence of metastasis, and the patients were classified based on the types of cancer. Total RNA and miRNA were isolated from the obtained biopsy samples. The quantitative analysis of hsa-miR-21-5p, hsa-miR-222-3p, and hsa-miR-221-3p and their target genes was performed by the RT-qPCR method. In determining oxidative stress, total antioxidant status and total oxidant status in tissue and total thiol and native thiol in blood were determined spectrophotometrically. OSI and disulfide were calculated. RESULTS: We discovered that the metastasis group had higher levels of hsa-miR-21-5p, hsa-miR-221-3p, and hsa-miR-222-3p (p<0.05). While TIMP3, PTEN, and apoptotic genes decreased in metastasis, anti-apoptotic genes increased (p<0.05). In addition, while oxidative stress decreased in the metastasis group, no change was found in the serum (p>0.05). CONCLUSION: Our findings show that upregulation of hsa-miR-21-5p, hsa-miR-221-3p, and hsa-miR-222-3p effectively contributes to both proliferation and invasion by influencing oxidative stress and mitochondrial apoptosis.

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Protective effect of irbesartan against hepatic ischemia–reperfusion injury in rats: role of ERK, STAT3, and PPAR-γ inflammatory pathways in rats

El-Marasy,

Mostafa,

Mabrok

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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This study aimed to elucidate the possible hepatocellular protective role of irbesartan during hepatic ischemia–reperfusion injury (HIRI) and the probable underlying mechanisms. Wistar rats were allocated into four groups: sham; HIRI (control); irbesartan (50 mg/kg) + HIRI; irbesartan (100 mg/kg) + HIRI; irbesartan + GW9662 (1 mg/kg, i.p.) + HIRI. Rats pretreated orally with irbesartan or vehicle for 14 days underwent 45-min hepatic ischemia followed by 60-min reperfusion. Irbesartan preconditioning diminished alanine transaminase (ALT) and aspartate transaminase (AST) serum levels, and reduced extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3). Irbesartan decreased proapoptotic BAX (bcl-2-like protein 4), increased anti-apoptotic B-cell lymphoma 2 (BCL2) hepatic content, and thereby reduced BAX/BCL2 ratio. Moreover, irbesartan preconditioning reduced autophagy-related proteins Beclin1 and LC3 II, and elevated p62 (protein responsible for autophagosome degradation). It elevated proliferator-activated receptor γ (PPAR-γ), and reduced tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) hepatic gene expression. Also, hepatic protein expressions of nuclear factor kappa-B p65 (NF-κB p65) and caspase-3 were lessoned by irbesartan pretreatment in HIRI rats. However, GW9662 abrogated irbesartan's effect on HIRI. The protective effect of irbesartan on HIRI may be mediated by alleviation of ERK, STAT3, and PPAR-γ inflammatory pathways, exerting anti-apoptotic and anti-autophagic effects in HIRI in rats.

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Irbesartan decreased mitochondrial stress related apoptosis in cisplatin induced acute kidney injury via regulating BCL-2/BAX signaling

Cited by 6 publications

References 43 publications

Ovotransferrin alleviated acute gastric mucosal injury in BALB/c mice caused by ethanol

Ovotransferrin alleviated acute gastric mucosal injury in BALB/c mice caused by ethanol

miR-21, miR-221, and miR-222 upregulation in lung cancer promotes metastasis by reducing oxidative stress and apoptosis

Protective effect of irbesartan against hepatic ischemia–reperfusion injury in rats: role of ERK, STAT3, and PPAR-γ inflammatory pathways in rats

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