Irbesartan attenuates production of high-mobility group box 1 in response to lipopolysaccharide via downregulation of interferon-β production

Kato, Yoshiro; Kawanishi, Hideki; Koide, Naoki; Odkhuu, Erdenezaya; Komatsu, Takayuki; Watarai, Atsuko; Kondo, Masaki; Kato, Koichi; Nakamura, Jiro; Yokochi, Takashi

doi:10.1016/j.intimp.2015.03.015

Cited by 4 publications

(3 citation statements)

References 33 publications

(35 reference statements)

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“…Irbesartan exerts a neuroprotective effect by inhibiting the activation of microglia and macrophages [132]. This medicament reduces the production of IFN-beta and the expression of iNOS, and thus inhibiting NO production [133]. Irbesartan also inhibits the expression of MCP-1 mRNA in THP-1 monocyte cell line stimulated with TNF-α and activates PPARγ [134].…”

Section: Candesartan Irbesartanmentioning

confidence: 99%

“…the general number of immune cells in bronchoalveolar lavage fluid [125]; -the release of Th2-lymphocyte (IL-4, IL-5 and IL-13) and Th1-lymphocyte (IL-2 and IFN-γ) cytokines [125]; -inhibiting the activation of microglia and macrophages [132]; -the production of IFN-beta and the expression of iNOS, and thus inhibits NO production [133]; -expression of MCP-1 mRNA in THP-1 monocyte cell line stimulated with TNF-α and activates PPARγ [134]; -macrophage infiltration [136].…”

Section: Reduction Inmentioning

confidence: 99%

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Immunomodulatory Activity of the Most Commonly Used Antihypertensive Drugs—Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers

Bryniarski

Nazimek

Marcinkiewicz

2022

IJMS

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This review article is focused on antihypertensive drugs, namely angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB), and their immunomodulatory properties reported in hypertensive patients as well as in experimental settings involving studies on animal models and cell lines. The immune regulatory action of ACEI and ARB is mainly connected with the inhibition of proinflammatory cytokine secretion, diminished expression of adhesion molecules, and normalization of CRP concentration in the blood plasma. The topic has significant importance in future medical practice in the therapy of patients with comorbidities with underlying chronic inflammatory responses. Thus, this additional effect of immune regulatory action of ACEI and ARB may also benefit the treatment of patients with metabolic syndrome, allergies, or autoimmune disorders.

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Section: Candesartan Irbesartanmentioning

confidence: 99%

Section: Reduction Inmentioning

confidence: 99%

Immunomodulatory Activity of the Most Commonly Used Antihypertensive Drugs—Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers

Bryniarski

Nazimek

Marcinkiewicz

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…22,23) Furthermore, in vitro, the expression levels of HMGB1 are reduced by inhibiting AT1 receptor activation following stimulation with lipopolysaccharide. 24) The aforementioned findings, along with the fact that Ang II is increased under PO 2 and that HMGB1 expression is enhanced by mechanical stress in cultured cardiac myocytes, 16) led to the hypothesis that Ang II may regulate the expression and release of HMGB1 in hearts under PO through AT1 and AT2 receptor signaling. The present study explored this hypothesis by blocking Ang II receptors in transverse aortic constriction (TAC)-induced hypertrophic mice in vivo and in cardiac myocytes treated with Ang II in vitro.…”

mentioning

confidence: 99%

Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload

Zhang

et al. 2021

Int. Heart J.

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High-mobility group box 1 (HMGB1) is increased in the myocardium under pressure overload (PO) and is involved in PO-induced cardiac remodeling. The mechanisms of the upregulation of cardiac HMGB1 expression have not been fully elucidated. In the present study, a mouse transverse aortic constriction (TAC) model was used, and an angiotensin II (Ang II) type 1 (AT1) receptor inhibitor (losartan) or Ang II type 2 (AT2) receptor inhibitor (PD123319) was administrated to mice for 14 days. Cardiac myocytes were cultured and treated with Ang II for 5 minutes to 48 hours conditionally with the blockage of the AT1 or AT2 receptor. TAC-induced cardiac hypertrophy was observed at 14 days after the operation, which was partially reversed by losartan, but not by PD123319. Similarly, the upregulated HMGB1 expression levels observed in both the serum and myocardium induced by TAC were reduced by losartan. Elevated cardiac HMGB1 protein levels, but not mRNA or serum levels, were significantly decreased by PD123319. Furthermore, HMGB1 expression levels in culture media and cardiac myocytes were increased following Ang II treatment in vitro, positively associated with the duration of treatment. Similarly, Ang II-induced upregulation of HMGB1 in vitro was inhibited by both losartan and PD 123319. These results suggest that upregulation of HMGB1 in serum and myocardium under PO, which are partially derived from cardiac myocytes, may be induced by Ang II via the AT1 and AT2 receptors. Additionally, amelioration of PO-induced cardiac hypertrophy following losartan treatment may be associated with the reduction of HMGB1 expression through the AT1 receptor.

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Irbesartan reprofiling for the amelioration of ethanol-induced gastric mucosal injury in rats: Role of inflammation, apoptosis, and autophagy

et al. 2022

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Irbesartan attenuates production of high-mobility group box 1 in response to lipopolysaccharide via downregulation of interferon-β production

Cited by 4 publications

References 33 publications

Immunomodulatory Activity of the Most Commonly Used Antihypertensive Drugs—Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers

Immunomodulatory Activity of the Most Commonly Used Antihypertensive Drugs—Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers

Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload

Irbesartan reprofiling for the amelioration of ethanol-induced gastric mucosal injury in rats: Role of inflammation, apoptosis, and autophagy

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