Ira: a free and open-source Fourier transform infrared (FTIR) data analysis widget for pharmaceutical applications

Nasereddin, Jehad; Shakib, Mohammed

doi:10.1080/00032719.2023.2180516

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…A comprehensive spectrum encompassing a range of components including Span 60, Tween 60, Chol, DCP, DOX, a physical mixture of DOX niosomes, blank niosomes, and FT5 niosomes was generated in the wavenumber range of 4000–400 cm –1 at 2 cm –1 resolution with 32 scans per spectrum. The spectral data collected was saved in CSV format and processed with Ira version 1 …”

Section: Methodsmentioning

confidence: 99%

Transdermal Delivery System of Doxycycline-Loaded Niosomal Gels: Toward Enhancing Doxycycline Stability

Zaid Alkilani,

Sharaire,

Hamed

et al. 2024

ACS Omega

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Doxycycline (DOX) is an antimicrobial agent that is susceptible to photosensitivity and thermal degradation. It addition, it causes gastrointestinal side effects when taken orally. Therefore, the development of alternative formulations is necessary to improve drug stability and promote patient compliance. The aim of the present study was to encapsulate DOX in niosomes as a nanocarrier to deliver DOX transdermally and enhance its stability in the formulation. DOX niosomes were prepared using nonionic surfactants, cholesterol, and dihexadecyl phosphate (DCP). After that, niosomes were characterized in terms of practical size (PS), zeta potential (ZP), morphology, and entrapment efficacy (EE%). DOX niosomal gels were then prepared using Carbopol and penetration enhancers (poly(ethylene glycol) 400 (PEG 400) and propylene glycol (PG)). The flux of DOX from the optimized formula was 322.86 μg/cm 2 /h over 5 h, which equates to 71.2% of DOX. Furthermore, neither the DOX niosomal gel (D3) nor the comparable blank niosomal gel had a negative influence on human dermal fibroblast (HDF) cells. The findings of the antimicrobial effectiveness of DOX niosomes indicated that the niosomal formulation improved the antibacterial activity of DOX against E. coli. Permeation studies demonstrated significantly higher DOX permeation when the niosomal gel was applied to rat skin, compared to the conventional gel. Permeability parameters such as flux and the permeability coefficient increased more than 10-fold using the niosomal gels compared with those of conventional gels. In conclusion, a new niosomal gel formulation could serve as an effective alternative for the commercially available form of DOX.

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Section: Methodsmentioning

confidence: 99%

Transdermal Delivery System of Doxycycline-Loaded Niosomal Gels: Toward Enhancing Doxycycline Stability

Zaid Alkilani,

Sharaire,

Hamed

et al. 2024

ACS Omega

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“…The FTIR spectra were acquired in absorbance mode using a PerkinElmer UATR-II device (Waltham, MA, USA) using a wavelength range of 4000 cm −1 – 550 cm −1 with a scanning resolution of 4 cm −1 and 32 repeated scans at room temperature. The acquired spectra were then exported in Comma Separated Values (CSV) format and analyzed using Ira FTIR Data Explorer Build #210223 (Zarqa University, Zarqa, Jordan) [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Design of colon-targeted drug delivery of dexamethasone: Formulation and in vitro characterization of solid dispersions

Zaid Alkilani,

Omar,

Nasereddin

et al. 2024

Heliyon

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“…The collected spectral data was saved in. CSV format and analyzed with Ira Version 1 [38]. The ATR-FTIR method was used to evaluate the spectra of AA, CAFF, Span 60, Chol and Tween 80.…”

Section: Attenuated Total Reflectance-fourier Transform Infrared Spec...mentioning

confidence: 99%

Development and Evaluation of an Innovative Approach Using Niosomes Based Polymeric Microneedles to Deliver Dual Antioxidant Drugs

et al. 2023

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Ascorbic acid (AA) and caffeine (CAFF) work to protect cells from ultraviolet (UV) radiation and slow down the photoaging process of the skin. However, cosmetic application of AA and CAFF is limited due to poor penetration across the skin and rapid oxidation of AA. The aim of this study was to design and evaluate the dermal delivery of dual antioxidants utilizing microneedles (MNs) loaded with AA and CAFF niosomes. The niosomal nanovesicles were prepared using the thin film method and had particle sizes ranging from 130.6–411.2 nm and a negative Zeta potential of around −35 mV. The niosomal formulation was then combined with polyvinylpyrrolidone (PVP) and polyethylene glycol 400 (PEG 400) to create an aqueous polymer solution. The best skin deposition of AA and CAFF was achieved with the formulation containing 5% PEG 400 (M3) and PVP. Furthermore, the role of AA and CAFF as antioxidants in preventing cancer formation has been well-established. Here we validated the antioxidant properties of ascorbic acid (AA) and caffeine (CAFF) in a novel niosomal formulation referred to as M3 by testing its ability to prevent H2O2-indued cell damage and apoptosis in MCF-7 breast cancer cells. Results showed that M3 was able to shield MCF-7 cells from H2O2 induced damage at concentrations below 2.1 µg/mL for AA and 1.05 µg/mL for CAFF, and also exhibited anticancer effects at higher concentrations of 210 µg/mL for AA and 105 µg/mL. The formulations were stable for two months at room temperature in terms of moisture and drug content. The use of MNs and niosomal carriers could be a promising approach for dermal delivery of hydrophilic drugs like AA and CAFF.

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Ira: a free and open-source Fourier transform infrared (FTIR) data analysis widget for pharmaceutical applications

Cited by 5 publications

References 35 publications

Transdermal Delivery System of Doxycycline-Loaded Niosomal Gels: Toward Enhancing Doxycycline Stability

Transdermal Delivery System of Doxycycline-Loaded Niosomal Gels: Toward Enhancing Doxycycline Stability

Design of colon-targeted drug delivery of dexamethasone: Formulation and in vitro characterization of solid dispersions

Development and Evaluation of an Innovative Approach Using Niosomes Based Polymeric Microneedles to Deliver Dual Antioxidant Drugs

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