IR Spectra of Paracetamol and Phenacetin. 1. Theoretical and Experimental Studies

The interplay between the paracetamol polymorphism and its molecular structures dissolved in supercritical CO2 in contact with the solid phase: In situ vibration spectroscopy and molecular dynamics simulation analysis

“…In the case of IR-spectra (see Fig. 6), the presence of polymorph II in Recry.1 sample is demonstrated by five spectral regions: 1200-1300 cm À1 , 1300-1400 cm À1 , 1400-1500 cm À1 , 1500-1600 cm À1 , 1600-1700 cm À1 (Al-Zoubi et al, 2002;Burgina et al, 2004;Ivanova, 2005;Moynihan and O'Hare, 2002). These findings are in accordance with the interpretation of DSC signals.…”

“…Since conformations of paracetamol molecules at different polymorphic forms are only slightly different from each other, the crystalline paracetamol is one of the representatives of packing polymorphism. (Burgina et al, 2004;Ivanova, 2005;Wilson, 1997). Paracetamol was a subject of many studies whose aim is the rationalization of its thermal behavior.…”

Recrystallization of phenacetin and sulfathiazole using the sonocrystallization process

“…This observation is also confirmed by the FTIR results presented in the supporting material. In this study, the obtaining DSC, PXRD and FTIR results are all consistent with literature finding [20][21][22][23].…”

Direct evidence of polyamorphism in paracetamol

“…Taking into account those results and our findings, hydrogen bonds also define the amorphous phases with the effect on the paracetamol molecule characteristics including methyl Please do not adjust margins Please do not adjust margins group interaction and angle between phenyl plane and acetamido group. 47, 48 We assume that the amorphous states already contain polymorph-specific (proto-crystalline) information controlled by the nature of the solvent. To obtain structural information on these amorphous precursors, PDF analyses based on high resolution synchrotron data were used.…”