IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy

Yue, Caixia; Liu, Peng; Zheng, Mingbin; Zhao, Pengfei; Wang, Yiqing; Ma, Yifan; Cai, Lintao

doi:10.1016/j.biomaterials.2013.05.071

Cited by 328 publications

(281 citation statements)

References 33 publications

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“…Near-infrared light-triggered over 42.5°C could lead to the death of cancer cells, [42][43][44] the result verified the excellent light-induced hyperthermia and PTT effect of LTCAs. By contrast, no obvious temperature increase at the tumor site was recorded in the control group and surrounding normal tissues in LATCAs group.…”

mentioning

confidence: 60%

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Wu¹,

Wang²,

Lu³

et al. 2017

IJN

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The major challenge in current clinic contrast agents (CAs) and chemotherapy is the poor tumor selectivity and response. Based on the self-quench property of IR820 at high concentrations, and different contrast effect ability of Gd-DOTA between inner and outer of liposome, we developed “bomb-like” light-triggered CAs (LTCAs) for enhanced CT/MRI/FI multimodal imaging, which can improve the signal-to-noise ratio of tumor tissue specifically. IR820, Iohexol and Gd-chelates were firstly encapsulated into the thermal-sensitive nanocarrier with a high concentration. This will result in protection and fluorescence quenching. Then, the release of CAs was triggered by near-infrared (NIR) light laser irradiation, which will lead to fluorescence and MRI activation and enable imaging of inflammation. In vitro and in vivo experiments demonstrated that LTCAs with 808 nm laser irradiation have shorter T 1 relaxation time in MRI and stronger intensity in FI compared to those without irradiation. Additionally, due to the high photothermal conversion efficiency of IR820, the injection of LTCAs was demonstrated to completely inhibit C6 tumor growth in nude mice up to 17 days after NIR laser irradiation. The results indicate that the LTCAs can serve as a promising platform for NIR-activated multimodal imaging and photothermal therapy.

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mentioning

confidence: 60%

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Wu¹,

Wang²,

Lu³

et al. 2017

IJN

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“…This is well correlated with previously reported studies. 58,59 In the HPLC quantification of DOCT from the MKN-28 cancer-bearing mice, a time-dependent reduction in plasma concentration of DOCT was observed, indicating eventual clearance of the Nps or the released DOCT from the circulation following the hepatic or renal route as indicated by liver and kidney accumulation, respectively. Studies have reported that even PEG modification could not enhance the circulation time, and that the Nps were cleared by the RES system following liver and spleen accumulation.…”

mentioning

confidence: 99%

In vivo evaluation of cetuximab-conjugated poly(γ-glutamic acid)-docetaxel nanomedicines in EGFR-overexpressing gastric cancer xenografts

Sreeranganathan

Uthaman

Sarmento

et al. 2017

IJN

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Epidermal growth factor receptor (EGFR), upregulated in gastric cancer patients, is an oncogene of interest in the development of targeted cancer nanomedicines. This study demonstrates in silico modeling of monoclonal antibody cetuximab (CET MAb)-conjugated docetaxel (DOCT)-loaded poly(γ-glutamic acid) (γ-PGA) nanoparticles (Nps) and evaluates the in vitro/in vivo effects on EGFR-overexpressing gastric cancer cells (MKN-28). Nontargeted DOCT-γ-PGA Nps (NT Nps: 110±40 nm) and targeted CET MAb-DOCT-γ-PGA Nps (T Nps: 200±20 nm) were prepared using ionic gelation followed by 1-Ethyl-3-(3-dimethyl aminopropyl)carbodiimide–N-Hydoxysuccinimide (EDC–NSH) chemistry. Increased uptake correlated with enhanced cytotoxicity induced by targeted Nps to EGFR +ve MKN-28 compared with nontargeted Nps as evident from MTT and flow cytometric assays. Nanoformulated DOCT showed a superior pharmacokinetic profile to that of free DOCT in Swiss albino mice, indicating the possibility of improved therapeutic effect in the disease model. Qualitative in vivo imaging showed early and enhanced tumor targeted accumulation of CET MAb-DOCT-γ-PGA Nps in EGFR +ve MKN-28–based gastric cancer xenograft, which exhibited efficient arrest of tumor growth compared with nontargeted Nps and free DOCT. Thus, actively targeted CET MAb-DOCT-γ-PGA Nps could be developed as a substitute to conventional nonspecific chemotherapy, and hence could become a feasible strategy for cancer therapy for EGFR-overexpressing gastric tumors.

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“…42 Both MHI-148 and IR-780 are lipid-soluble compounds and show toxic effects, which are tolerated in mice but limit the application of these dyes in vivo. The sulfonic acid group in the side chain of IR-783 allows better water solubility and lower toxicity through a quick clearance in vivo, but its structural modification remains difficult.…”

Section: Physical and Chemical Characteristics Of Near-infrared Fluormentioning

confidence: 99%

“…36 Encapsulating NIRF dyes with polymers or inorganic materials to form a variety of nonmetallic nanoparticles also enhanced the photostability, biocompatibility, and fluorescence intensity of dyes with reduced self-aggregation to improve PDT efficacy. 42,[80][81][82] As a conventional NIR dye, ICG has limited applications as a specific imaging agent for cancer detection because of poor stability and rapid decomposition in polar solution. When ICG was attached to cationic polyethylene to form silicon nanoparticles, the degradation and fluorescence quenching of ICG was largely reduced.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy

2016

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Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy," J. Biomed. Opt. 21(5), 050901 (2016), doi: 10.1117/1.JBO.21.5.050901. Abstract. A class of near-infrared fluorescence (NIRF) heptamethine cyanine dyes that are taken up and accumulated specifically in cancer cells without chemical conjugation have recently emerged as promising tools for tumor imaging and targeting. In addition to their fluorescence and nuclear imagingbased tumor-imaging properties, these dyes can be developed as drug carriers to safely deliver chemotherapy drugs to tumors. They can also be used as effective agents for photodynamic therapy with remarkable tumoricidal activity via photodependent cytotoxic activity. The preferential uptake of dyes into cancer but not normal cells is co-operatively mediated by the prevailing activation of a group of organic aniontransporting polypeptides on cancer cell membranes, as well as tumor hypoxia and increased mitochondrial membrane potential in cancer cells. Such mechanistic explorations have greatly advanced the current application and future development of NIRF dyes and their derivatives as anticancer theranostic agents. This review summarizes current knowledge and emerging advances in NIRF dyes, including molecular characterization, photophysical properties, multimodal development and uptake mechanisms, and their growing potential for preclinical and clinical use.

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IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy

Cited by 328 publications

References 33 publications

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

In vivo evaluation of cetuximab-conjugated poly(γ-glutamic acid)-docetaxel nanomedicines in EGFR-overexpressing gastric cancer xenografts

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy

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IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy

Cited by 328 publications

References 33 publications

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

In vivo evaluation of cetuximab-conjugated poly(&gamma;-glutamic acid)-docetaxel nanomedicines in EGFR-overexpressing gastric cancer xenografts

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy

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In vivo evaluation of cetuximab-conjugated poly(γ-glutamic acid)-docetaxel nanomedicines in EGFR-overexpressing gastric cancer xenografts