IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma

Meng, Quan Fei; Li, Can-Xuan; Liang, De; Lin, Xiaobin

doi:10.2147/ijgm.s316280

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…We have previously shown that the expression of IQGAP3 is associated with tumor progression in gastric cancer [11]. IQGAP3 has been reported to be upregulated in hepatocellular [18], clear cell renal cell [29,30] carcinomas, high-grade serous ovarian [31] and lung [20] cancers, respectively.…”

Section: Discussionmentioning

confidence: 98%

IQ Motif Containing GTPase-Activating Protein 3 Is Associated with Cancer Stemness and Survival in Pancreatic Ductal Adenocarcinoma

Kido,

Ishikawa,

Fukui

et al. 2023

Pathobiology

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Introduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of malignancy, with poor prognosis and rising incidence. IQ motif-containing GTPase-activating protein 3 (IQGAP3) is a member of the IQGAPs family of scaffolding proteins that govern multiple cellular activities like cytoskeletal remodeling and cellular signal transduction. This study aimed to analyze the expression and biological function of IQGAP3 in PDAC. Methods: We analyzed IQGAP3 expression in 81 PDAC samples by immunohistochemistry. RNA interference was used to inhibit IQGAP3 expression in PDAC cell lines. Results: Immunohistochemical analysis of IQGAP3 showed that 54.3% of PDACs were positive for cytoplasmic expression of IQGAP3, with no expression found in non-neoplastic tissue. Furthermore, IQGAP3 expression was an independent poor prognostic factor in our immunostaining-based studies and analyses of public databases. Our cohort and The Cancer Genome Atlas database indicated that IQGAP3 is co-localized with kinesin family member C1 (KIFC1), which we previously reported as a cancer stem cell-associated protein. IQGAP3 siRNA treatment decreased PDAC cell proliferation and spheroid colony formation via ERK and AKT pathways. Discussion/Conclusion: These results suggest that IQGAP3, a transmembrane protein, is involved in survival and stemness and may be a promising new therapeutic target for PDAC.

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Section: Discussionmentioning

confidence: 98%

IQ Motif Containing GTPase-Activating Protein 3 Is Associated with Cancer Stemness and Survival in Pancreatic Ductal Adenocarcinoma

Kido,

Ishikawa,

Fukui

et al. 2023

Pathobiology

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“…IQGAP3 is crucial for cell cycle, genome stability and tumor stem cell potential [ 27 ]. Growing evidence suggests that IQGAP3 is a biogenetic or prognostic marker of malignancy that promotes migration, invasion, and drug resistance in many human malignancies [ 28 ], such as gastric cancer [ 29 ], clear cell renal cell carcinoma [ 13 ], bladder cancer [ 30 ], and liver cancer [ 31 ]. This suggests that IQGAP3 may be an important oncogene.…”

Section: Discussionmentioning

confidence: 99%

IQGAP3 promotes the progression of glioma as an immune and prognostic marker

GAO,

GE,

GAO

et al. 2024

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Background: IQGAP3 plays a crucial role in regulating cell proliferation, division, and cytoskeletal organization. Abnormal expression of IQGAP3 has been linked to various tumors, but its function in glioma is not well understood. Methods: Various methods, including genetic differential analysis, single-cell analysis, ROC curve analysis, Cox regression, Kaplan-Meier analysis, and enrichment analysis, were employed to analyze the expression patterns, diagnostic potential, prognostic implications, and biological processes involving IQGAP3 in normal and tumor tissues. The impact of IQGAP3 on immune infiltration and the immune microenvironment in gliomas was evaluated using immunofluorescence. Additionally, the cBioPortal database was used to analyze copy number variations and mutation sites of IQGAP3. Experimental validation was also performed to assess the effects of IQGAP3 on glioma cells and explore underlying mechanisms. Results: High IQGAP3 expression in gliomas is associated with an unfavorable prognosis, particularly in wild-type IDH and 1p/19q non-codeleted gliomas. Enrichment analysis revealed that IQGAP3 is involved in regulating the cell cycle, PI3K/AKT signaling, p53 signaling, and PLK1-related pathways. Furthermore, IQGAP3 expression may be closely related to the immunosuppressive microenvironment of glioblastoma. BRD-K88742110 and LY-303511 are potential drugs for targeting IQGAP3 in anti-glioma therapy. In vitro experiments showed that downregulation of IQGAP3 inhibits the proliferation and migration of glioma cells, with the PLK1/PI3K/AKT pathway potentially playing a crucial role in IQGAP3-mediated glioma progression. Conclusion: IQGAP3 shows promise as a valuable biomarker for diagnosis, prognosis, and immunotherapeutic strategies in gliomas.

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IQGAP3 is relevant to prostate cancer: A detailed presentation of potential pathomechanisms

Mei

Dong

et al. 2023

Journal of Advanced Research

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IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma

Cited by 3 publications

References 41 publications

IQ Motif Containing GTPase-Activating Protein 3 Is Associated with Cancer Stemness and Survival in Pancreatic Ductal Adenocarcinoma

IQ Motif Containing GTPase-Activating Protein 3 Is Associated with Cancer Stemness and Survival in Pancreatic Ductal Adenocarcinoma

IQGAP3 promotes the progression of glioma as an immune and prognostic marker

IQGAP3 is relevant to prostate cancer: A detailed presentation of potential pathomechanisms

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