IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL

Abstract

Background Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will provide therapeutic targets. IQ motif-containing GTPase activating protein 2 (IQGAP2) acts as a tumour suppressor in hepatocellular, prostate, and gastric cancers. However, the role of IQGAP2 in DLBCL remains unclear. Methods We collected mRNA expression data from 614 samples and the corresponding clinical information. The survival time of patients was compared between groups according to the mRNA expression level of IQGAP2. Survival analyses were performed in different subgroups when considering the effect of age, tumour stage, serum lactate dehydrogenase (LDH) concentration, performance status, and the number of extra nodal disease sites. The biological processes associated with IQGAP2-associated mRNAs were analysed to predict the function of IQGAP2. The correlation of IQGAP2 mRNA with immunosuppressive genes and leukocyte infiltration were analysed. Results The overall survival of patients with increased IQGAP2 mRNA levels was reduced even after aggressive treatment independent of age, tumour stage, serum LDH concentration, performance status, and the number of extra nodal disease sites. Furthermore, the biological processes of IQGAP2-associated mRNAs were mainly immune processes. IQGAP2 mRNA expression was correlated with the expression of immunosuppressive genes and leukocyte infiltration. Conclusion IQGAP2 mRNA is an independent prognostic factor and is related to immunosuppression in DLBCL. This discovery may provide a promising target for further development of therapy.

Comprehensive sex-stratified genetic analysis of 28 blood biomarkers and depression reveals a significant association between depression and low levels of total protein in females

“…Our results also indicated that a low level of total protein is associated with genetic liability to female depression including PND. Fine-grained local genetic correlation analysis implicated IQGAP2, for which increased expression has been associated with immunosuppression and poor prognosis in lymphoma [69] but improved prognosis in breast cancer [70]. Nominally significant local negative genetic correlation for total protein with female depression was found for the 5p15.33 genomic region, which contains TERT, associated with the length of telomeres and associated genomic stability [71].…”

Construction and validation of an immune infiltration-related risk model for predicting prognosis and immunotherapy response in low grade glioma

“…IQGAP2 has been reported as a tumor suppressor in hepatocellular cancer, prostate cancer, and gastric cancer [ 35 ]. However, IQGAP2 is a negative prognostic factor and is associated with immunosuppression in diffuse large B-cell lymphoma [ 36 ]. IQGAP2 was defined as a risk-conferring gene in this study and its role in LGG needs further study.…”

Upregulation of Actin-Related Protein 2 (ACTR2) Exacerbated the Malignancy of Diffuse Large B-Cell Lymphoma through Activating Wnt Signaling

“…Higher CCND2 expression is associated with more efficient R-CHOP treatment and better prognosis of ABC-DLBCL [ 20 ]. High IQGAP2 level predicted shorter OS of DLBCL and was positively related to immunosuppressive gene expression in DLBCL [ 21 ]. The current investigation used TCGA database and uncovered the dysregulation of ACTR2 in 14 types of human cancer tissues in addition to DLBCL, suggesting its potential importance in cancer progression.…”