Ipsilesional Arm Motor Sequence Performance After Right and Left Hemisphere Damage

Silva, Flávia Priscila de Paiva; Freitas, Sandra Maria Sbeghen Ferreira de; Silva, Priscila Viana; Banjai, Renata Morales; Alouche, Sandra Regina

doi:10.1080/00222895.2014.924473

Cited by 17 publications

(14 citation statements)

References 35 publications

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“…Previous work suggests that deficits in the ipsilesional arm and hand varies with the severity of contralesional deficits, especially in the sub-acute and chronic phase after stroke (5)(6)(7)(8). More interestingly, the unilateral motor deficits observed for contralesional and ipsilesional limbs seem to be hemisphere-specific and thus depend on side of stroke lesion (9)(10)(11)(12)(13)(14)(15). For predominantly righthanded cohorts, contralesional deficits appear to be more severe in those with right hemisphere damage (RHD), in whom the contralesional limb is non-dominant.…”

Section: Introductionmentioning

confidence: 93%

Relationship Between Motor Capacity of the Contralesional and Ipsilesional Hand Depends on the Side of Stroke in Chronic Stroke Survivors With Mild-to-Moderate Impairment

Varghese

Winstein

2020

Front. Neurol.

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There is growing evidence that after a stroke, sensorimotor deficits in the ipsilesional hand are related to the degree of impairment in the contralesional upper extremity. Here, we asked if the relationship between the motor capacities of the two hands differs based on the side of stroke. Forty-two pre-morbidly right-handed chronic stroke survivors (left hemisphere damage, LHD = 21) with mild-to-moderate paresis performed distal items of the Wolf Motor Function Test (dWMFT). We found that compared to RHD, the relationship between contralesional arm impairment (Upper Extremity Fugl-Meyer, UEFM) and ipsilesional hand motor capacity was stronger (R 2 LHD = 0.42; R 2 RHD < 0.01; z = 2.12; p = 0.03) and the slope was steeper (t = −2.03; p = 0.04) in LHD. Similarly, the relationship between contralesional dWMFT and ipsilesional hand motor capacity was stronger (R 2 LHD = 0.65; R 2 RHD = 0.09; z = 2.45; p = 0.01) and the slope was steeper (t = 2.03; p = 0.04) in LHD compared to RHD. Multiple regression analysis confirmed the presence of an interaction between contralesional UEFM and side of stroke (β 3 = 0.66 ± 0.30; p = 0.024) and between contralesional dWMFT and side of stroke (β 3 = −0.51 ± 0.34; p = 0.05). Our findings suggest that the relationship between contraand ipsi-lesional motor capacity depends on the side of stroke in chronic stroke survivors with mild-to-moderate impairment. When contralesional impairment is more severe, the ipsilesional hand is proportionally slower in those with LHD compared to those with RHD.

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Section: Introductionmentioning

confidence: 93%

Relationship Between Motor Capacity of the Contralesional and Ipsilesional Hand Depends on the Side of Stroke in Chronic Stroke Survivors With Mild-to-Moderate Impairment

Varghese

Winstein

2020

Front. Neurol.

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“…Finally, we identify the limitations of this study and suggest future research questions. movements 15 , and thus, injury to the left hemisphere, particularly to premotor and fronto-parietal networks (e.g. IPC) 27, 28 may impair planning and sequencing required for smooth and rapid performance of dexterous motor tasks.…”

Section: Discussionmentioning

confidence: 99%

“…10 In addition to the studies aimed at characterizing the relationship between contralesional and ipsilesional hands, there is mounting evidence that the unilateral motor deficits observed for contralesional and ipsilesional are hemisphere-specific and thus depend on side of stroke lesion. 8, [11][12][13][14][15][16] For example, using clinical motor assessments of grip strength and hand dexterity, Harris and Eng 13 showed that in chronic stroke survivors who are pre-morbidly right-hand dominant, contralesional motor impairments were less severe in individuals who suffered damage in the dominant (i.e. left) hemisphere (LHD) compared to those who suffered damage in the non-dominant (right) hemisphere (RHD).…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Motor Capacity of the Contralesional and Ipsilesional Hand Depends on the Side of Stroke

Varghese

Winstein

2019

Preprint

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There is considerable evidence that after a stroke, ipsilesional deficits increase as contralesional impairment increases. However, it is unclear whether this relationship differs based on the side of stroke. Here, we tested the hypothesis that the ipsilesional hand motor capacity co-varies with contralesional hand impairment only in individuals with left hemisphere damage. Forty-two premorbidly right-handed chronic stroke survivors (left hemisphere damage, LHD = 21) with mildto-moderate paresis (Upper Extremity Fugl-Meyer-UEFM range: 19-59) performed distal items of the Wolf Motor Function Test (dWMFT). We used univariate co-efficient of determination ( " ) and multiple linear regression to assess the relationship between motor capacity of ipsilesional and contralesional hands. Contralesional UEFM, and dWMFT were found to be significant predictors of ipsilesional hand motor capacity (p < 0.0001 for both). Importantly, the relationship between contralesional and ipsilesional hands was significantly modified by side of stroke (model adjusted " = 0.26 and 0.42, respectively, p < 0.01). For individuals with LHD, contralesional impairment explained 42% and contralesional hand motor capacity explained 65% of the variance in ipsilesional hand motor capacity. However, this relationship was not statistically significant for individuals with right hemisphere damage (RHD, unadjusted " < 1% for UEFM and 9% for dWMFT, p > 0.05). In chronic stroke survivors with mild-to-moderate impairment, our findings demonstrate that the relationship between contralesional and ipsilesional motor deficits depends on the side of stroke. Specifically, deficits co-vary between the limbs of stroke survivors with left hemisphere damage but not right hemisphere damage. KeywordsIpsilesional deficits, stroke, hemispheric differences Interlimb Relationship is Hemisphere-Specific Interlimb Relationship is Hemisphere-Specific Analysis of the interaction effectBy preserving the continuity of the UEFM and utilizing continuous standardized z-scores, our statistical approach allowed a direct comparison of our regression parameters (i.e., ), thus reflecting effect sizes of each of the candidate predictors-contralesional impairment, side of lesion and their interaction. While contralesional impairment alone bore the largest effect on ipsilesional motor capacity ( 0 ), the second largest effect was through the interaction between contralesional UEFM and the side of lesion ( V ), and not the side of lesion alone ( " ). In fact, unlike previous findings, we did not observe a significant effect of the side of lesion on ipsilesional motor capacity 17,18 , nor on contralesional UEFM or dWMFT. 13 One reason for this might be that the effect of the side of lesion observed in those previous studies may have arisen from its interaction with contralesional impairment. However, because an interaction effect was not explicitly tested and because contralesional impairment was either collapsed across the groups 2,3,15 or catagorical 7,8 , variance in the ipsilesional capa...

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“…A vest was used to restrict trunk-associated movements (Figure 1). Silva et al, 2014. Prior to starting the experimental task, participants were familiarized with the experimental apparatus by moving the cursor toward targets located on the monitor screen in different positions from those analyzed during the experiment to avoid learning effects. Subsequently, the calibration of the targets position was made.…”

Section: Methodsmentioning

confidence: 99%

“…The direction of the movement also influences its execution. In most movement directions, the intersegmental coordination of the limb creates an interaction torque in the elbow joint due to the active movement of the shoulder (Dounskaia, 2005(Dounskaia, , 2010Dounskaia, Goble, & Wang, 2011;Dounskaia, Ketcham, & Stelmach, 2002).This coordination can be seen mostly in contralateral movements, which are slower, less smooth, and less precise than those directed to ipsilateral targets (Coqueiro, de Freitas, Silva, & Alouche, 2014;Ishihara et al, 2002;Silva, de Freitas, Silva, Banjai, & Alouche, 2014). For ipsilateral movements, fundamentally in the diagonal direction on the same side as the upper limb performing the movement, the elbow joint is responsible for starting the movement by active torque (Dounskaia, 2005(Dounskaia, , 2010Dounskaia et al, 2002;Galloway & Koshland, 2002).…”

Section: Introductionmentioning

confidence: 99%

Uncertainty in aiming movements and its association to hand function

Silva

Freitas

Comenalle

et al. 2015

Motriz: rev. educ. fis.

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Abstract--The purpose of this study was to analyze the influence of the uncertainty of target location on the planning and execution of aiming movements performed towards the ipsilateral and contralateral directions by the right and left upper limbs. In addition, the association between the performance of aiming movements and the performance of functional manual tasks was investigated. Two tasks were proposed: with prior knowledge of the movement direction (simple reaction time) or not (choice reaction time). The grip strength and manual dexterity were measured. The choice option in response (i.e. uncertainty) influenced planning of the aiming movements, but not its execution, while movements performed towards the contralateral direction were worse in execution as compared to the ipsilateral direction. Manual dexterity was significantly correlated with reaction times, while the performance during movement execution was significantly correlated with handgrip/pinch strength.Keywords: behavior, upper extremity, functional laterality, reaction time Resumo--"Incerteza de movimentos dirigidos ao alvo e sua associação com a função manual." O objetivo desse estudo foi avaliar a influência da incerteza da localização do alvo no planejamento e execução de movimentos dirigidos ao alvo realizados para as direções ipsilateral e contralateral pelos membros superiores direito e esquerdo. Em adição, a associação entre o desempenho do movimento dirigido ao alvo e o desempenho em tarefas manuais funcionais foi investigada. Duas tarefas foram propostas: com o conhecimento prévio da direção do movimento (tempo de reação simples) ou não (tempo de reação de escolha). Foram avaliadas a força de preensão palmar e a destreza manual. A opção de escolha na resposta (ex. incerteza) influenciou o planejamento do movimento dirigido ao alvo, mas não a sua execução, enquanto os movimentos realizados para a direção contralateral apresentaram pior execução quando comparados à direção ipsilateral. Destreza manual foi significativamente correlacionada com tempos de reação, enquanto o desempenho durante a execução do movimento foi significativamente correlacionado com forças de preensão/pinça. Palavras-chave: comportamento, membro superior, lateralidade funcional, tempo de reação Resumen--"La incertidumbre de movimientos dirigidos a la diana y su asociación con la función manual." El propósito de este estudio fue evaluar la influencia de la incertidumbre ubicación de la diana en la planificación y ejecución de movimientos dirigidos a la diana realizado por direcciones ipsilateral y contralateral por los miembros superiores derecho e izquierdo. Además, se investigó la asociación entre el rendimiento de movimiento dirigido a la diana y el rendimiento de la mano para tareas funcionales. Se propusieron dos tareas: con el conocimiento previo de la dirección del movimiento (tiempo de reacción simple) o no (tiempo de reacción del elección). Se evaluó la fuerza de prensión y la destreza manual. La opción de elección en responder (Incertidumbre por ejemplo....

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Ipsilesional Arm Motor Sequence Performance After Right and Left Hemisphere Damage

Cited by 17 publications

References 35 publications

Relationship Between Motor Capacity of the Contralesional and Ipsilesional Hand Depends on the Side of Stroke in Chronic Stroke Survivors With Mild-to-Moderate Impairment

Relationship Between Motor Capacity of the Contralesional and Ipsilesional Hand Depends on the Side of Stroke in Chronic Stroke Survivors With Mild-to-Moderate Impairment

Relationship Between Motor Capacity of the Contralesional and Ipsilesional Hand Depends on the Side of Stroke

Uncertainty in aiming movements and its association to hand function

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