Ipsilateral Radial Neuropathy after COVID-19 mRNA Vaccination in an Immunocompetent Young Man

Lee, Seon-Min; Hong, Jun Yeong; Kim, Si-Yeon; Na, Sang-Jun

doi:10.3349/ymj.2022.0038

Cited by 5 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reactive change was most frequently reported. A total of 36 studies including one single-center retrospective study [ 45 ], five case series [ 19 , 46 , 47 , 48 , 49 ] and 30 case reports [ 8 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ] revealed that C19-VAL is due to a reactive change in LN. It is an immune response for other vaccines [ 27 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…It is an immune response for other vaccines [ 27 , 34 ]. Pathological characterization shown in the 14 of 36 studies, including two case series [ 47 , 49 ] and 12 case reports [ 8 , 59 , 62 , 65 , 68 , 69 , 71 , 72 , 73 , 74 , 76 , 78 ], which directly shows the characterization of reactive change, such as reactive lymphadenitis, reactive hyperplasia, reactive follicular hyperplasia, extrafollicular proliferation of B-blasts and small lymphoid cells. Due to a lack of proper controls in those studies, current findings only indicated that reactive change is highly correlated with C19-VAL.…”

Section: Resultsmentioning

confidence: 99%

“…Those findings indicated that reactive change is also related to C19-VAL development. The pathological findings revealed that immune cell activation and proliferation are involved in the reactive change within LN [ 8 , 47 , 49 , 59 , 62 , 65 , 68 , 69 , 71 , 72 , 73 , 74 , 76 , 78 ]. Of these, the B cell germinal center response plays important roles in C19-VAL incidence based on results with anti-CD20 treatment [ 88 ].…”

Section: Resultsmentioning

confidence: 99%

“…Reactive change is a cause element for C19-VAL, which has been demonstrated in vaccinations for human papillomavirus [ 31 ] and smallpox [ 38 ]. Several pathological studies in this systematic review indicate that immune cell activation and proliferation are involved in the reactive change of LN [ 8 , 47 , 49 , 59 , 62 , 65 , 68 , 69 , 71 , 72 , 73 , 74 , 76 , 78 ]. Reactive change is a vaccine induced immune response [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination

Shen

Chang

et al. 2023

Vaccines

View full text Add to dashboard Cite

Mass vaccination against coronavirus disease 2019 (COVID-19) is a global health strategy to control the COVID-19 pandemic. With the increasing number of vaccinations, COVID-19 vaccine-associated lymphadenopathy (C19-VAL) has been frequently reported. Current findings emphasize the characteristics of C19-VAL. The mechanism of C19-VAL is complicated to explore. Accumulated reports separately show that C19-VAL incidence is associated with receiver age and gender, reactive change within lymph nodes (LN), etc. We constructed a systematic review to evaluate the associated elements of C19-VAL and provide the mechanism of C19-VAL. Articles were searched from PubMed, Web of Science and EMBASE by using the processing of PRISMA. The search terms included combinations of the COVID-19 vaccine, COVID-19 vaccination and lymphadenopathy. Finally, sixty-two articles have been included in this study. Our results show that days post-vaccination and B cell germinal center response are negatively correlated with C19-VAL incidence. The reactive change within LN is highly related to C19-VAL development. The study results suggested that strong vaccine immune response may contribute to the C19-VAL development and perhaps through the B cell germinal center response post vaccination. From the perspective of imaging interpretation, it is important to carefully distinguish reactive lymph nodes from metastatic lymph node enlargement through medical history collection or evaluation, especially in patients with underlying malignancy.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination

Shen

Chang

et al. 2023

Vaccines

View full text Add to dashboard Cite

show abstract

“…The remaining 54 articles, comprising 44 case reports and 10 case series, were included in the final quantitative synthesis. 11,14–66 The systematic review of these articles included individual data from 68 patients, who were categorized according to whether the likely trigger was COVID-19 infection or vaccination. The demographics and clinical characteristics of the patients are summarized in Table 1 and Table 2.…”

Section: Resultsmentioning

confidence: 99%

Association of Parsonage–Turner syndrome with COVID-19 infection and vaccination: a systematic review

Ameer,

Haiy,

Bajwa

et al. 2023

J Int Med Res

View full text Add to dashboard Cite

Objectives The exact etiology of Parsonage–Turner syndrome is unknown, but it is known to be preceded by infection, vaccination, or surgical intervention. In this review, we describe associations of Parsonage–Turner syndrome with COVID-19 infection and vaccination. Methods A systematic literature search was conducted using PubMed/MEDLINE, ScienceDirect, and Google Scholar. Microsoft Excel was used for data extraction and statistical analysis. The quality of case reports and case series was assessed using the Joanna Briggs Institute Critical Appraisal Tool. Results We selected 44 case reports and 10 case series, including 68 patients (32 post-vaccination and 36 with post-COVID-19 infection Parsonage–Turner syndrome). Middle-aged males were predominantly affected in both groups. The most frequently administered vaccine was Comirnaty (Pfizer) (53%). The mean latency was 11.7 days in the post-vaccination group and 20.3 days in the post-infection group. The most affected nerves in both groups were the axillary, suprascapular, and musculocutaneous nerves; and 78.1% and 38.9% of patients showed partial amelioration of their symptoms in the post-vaccination and post-infection groups, respectively. Conclusion Post-vaccination Parsonage–Turner syndrome presents earlier than post-infection disease. Pain and sensorimotor deficits of the upper limb are common in both situations. Complete or partial recovery occurs in most cases.

show abstract

Tozinameran

2022

Reactions Weekly

View full text Add to dashboard Cite

Ipsilateral Radial Neuropathy after COVID-19 mRNA Vaccination in an Immunocompetent Young Man

Cited by 5 publications

References 11 publications

Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination

Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination

Association of Parsonage–Turner syndrome with COVID-19 infection and vaccination: a systematic review

Tozinameran

Contact Info

Product

Resources

About