Ipsilateral local recurrence in relation to therapy and morphological characteristics in patients with ductal carcinomain situ of the breast

Tissue microarray analyses of G1/S-regulatory proteins in ductal carcinoma in situ of the breast indicate that low cyclin D1 is associated with local recurrence

“…A similar distribution of the ng was seen in the remaining, unsuccessfully biopsied, DCIS, suggesting that the 92 cases were representative for a general DCIS population without any obvious selection biases (data not shown). As reported earlier, the growth pattern of DCIS might be an important prognostic factor for ipsilateral local recurrence (Ringberg et al, 2000) and when classified according to Andersen et al, the growth pattern of the DCIS cases were: 16 cases microfocal (focusp5 mm, no stromal reaction), 33 tumour-forming (macroscopic lesion45 mm with stromal reaction), 37 diffuse ( þ /À macroscopically identifiable lesion, microscopically confluent þ /À stromal reaction) and six tumour-forming and diffuse growth pattern.…”

“…Andersen et al (1988) have further stressed the aspect of growth pattern in DCIS . Previous investigations, where the growth pattern has been divided into diffuse (including diffuse or tumourforming þ diffuse) and nondiffuse (including microfocal or tumour forming) have also shown that a diffuse growth pattern is associated with a higher recurrence rate (Ringberg et al, 2000).…”

“…Data from histopathological studies show that proliferative changes often are found in association with invasive cancer and both atypical ductal hyperplasia (ADH) and DCIS provide a significantly increased risk of subsequent invasive carcinoma (Dupont and Page, 1985;Eusebi et al, 1994) Treatment with mastectomy (ME) is curative in 95 -100% of all DCIS cases (Sunshine et al, 1985;Fentiman et al, 1986). Breast-conserving therapy (BCT) followed by postoperative radiotherapy (RT) provides a prognosis similar to ME (Ringberg et al, 2000), whereas patients having BCT without RT have an increased frequency of ipsilateral breast tumour recurrences (Ringberg et al, 2000).…”

“…Classification systems based on various differentiation aspects of DCIS seem to be clinically relevant, as the nuclear grade is strongly associated with disease recurrence (Ringberg et al, 2000;Boland et al, 2003). Unfortunately, the interobserver reproducibility of the analyses is low (Douglas-Jones et al, 2000;Wells et al, 2000) and there is still a need for a more objective basis for the classification of DCIS.…”

Histopathological risk factors for ipsilateral breast events after breast conserving treatment for ductal carcinoma in situ of the breast – Results from the Swedish randomised trial

“…A further drawback is that in retrospective evaluation of DCIS specimens, margins and lesions size are difficult to assess with the same validity as the other re-evaluated characteristics (7,13). For this reason, we refrained from classifying the lesions according to the Van Nuys´classification, size and margin status being central to that classification.…”