2014
DOI: 10.1179/2045772314y.0000000220
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Ipsilateral inspiratory intercostal muscle activity after C2 spinal cord hemisection in rats

Abstract: Background: Upper cervical spinal cord hemisection causes paralysis of the ipsilateral hemidiaphragm; however, the effect of C2 hemisection on the function of the intercostal muscles is not clear. We hypothesized that C2 hemisection would eliminate inspiratory intercostal activity ipsilateral to the injury and that some activity would return in a time-dependent manner. Methods: Female Sprague Dawley rats were anesthetized with urethane and inspiratory intercostal electromyogram (EMG) activity was recorded in c… Show more

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Cited by 11 publications
(10 citation statements)
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“…After C 2 SH, up to 50% of DIAm force‐generating capacity may be lost, which can certainly affect P di . Furthermore, there may be deficits in the activation of chest wall muscles following C 2 SH that alter chest wall compliance (Beth Zimmer et al., 2015; Denton & McKinlay, 2009), which may also affect P di . We hypothesise that 14‐day treatment with SPG302 will improve recovery of inspiratory‐related DIAm EMG and P di following C 2 SH.…”
Section: Introductionmentioning
confidence: 99%
“…After C 2 SH, up to 50% of DIAm force‐generating capacity may be lost, which can certainly affect P di . Furthermore, there may be deficits in the activation of chest wall muscles following C 2 SH that alter chest wall compliance (Beth Zimmer et al., 2015; Denton & McKinlay, 2009), which may also affect P di . We hypothesise that 14‐day treatment with SPG302 will improve recovery of inspiratory‐related DIAm EMG and P di following C 2 SH.…”
Section: Introductionmentioning
confidence: 99%
“…These data confirm the findings of previous studies (Wen and Lee, 2017). The recovery in activity of the ipsilateral external intercostals is more rapid then the seven-fourteen day time-lag shown following C2 hemisection (Beth Zimmer et al, 2015; Dougherty et al, 2012; Navarrete-Opazo et al, 2015) and is likely mediated through propriospinal interneurons which upregulate following trauma (Lane et al, 2008).…”
Section: Discussionmentioning
confidence: 96%
“…The implications of other respiratory related muscles (i.e. intercostals and abdominals, Fig 5B and 5C ) for maintaining a certain respiratory gazes exchange homeostasis and for compensating for the maintenance of respiratory function following a chronic C2 hemisection have already been demonstrated [ 36 , 37 ]. Interestingly, the injury size contributes to the spontaneous functional recovery as well as to the respiratory deficit.…”
Section: Discussionmentioning
confidence: 99%