Ipsilateral, cabled sural nerve for a sciatic nerve defect: An experimental model in the rat

Histologic and functional outcomes of nerve defects treated with acellular allograft versus cabled autograft in a rat model

“…In the setting of a matched‐diameter acellular allograft we believe it is the matching of the number of the endoneurial tubes to the injured nerve that is critical to appropriate nerve regeneration. Limitations in this study include the short distance of the segmental defect, the single outcome time point at 12 weeks, and the use of a relatively new method for nerve grafting in the rodent model . Future directions include the use of a longer injury model, multiple time points for outcome testing, and enhancement of the allograft with Schwann cells or pluripotent stem cells.…”

“…21 Lastly, these allografts have had chondroitin sulfate proteoglycans (CSPG) removed which has been shown to inhibit axonal growth. 13,23 Since the decellularization process can be applied to a variety of nerve lengths and diameters, the diameter of an acellular allograft can be matched to the injured nerve. Research has shown that axons regenerate through acellular nerve allografts, but the functional recovery is still controversial.…”

Potential of autologous adipose‐derived stem cells to regenerate atrophied muscle in a rat model

“…If possible, the nerve repair is thought to be the most effective method for reducing muscle atrophy of traumatic denervated muscles; however, that is not always possible in the clinical setting. In addition, the rat sciatic nerve is the most commonly used source in nerve injury studies because neural regeneration is generally good in rats, and the distance is short to target organs compared with other animals . In our study, we used a rat sciatic nerve injury model to mimic the two potential clinical situations of nerve injury as ND and NR models.…”

“…Particularly, peripheral nerve injuries affect up to 2.8% of trauma patients. Although various nerve repair methods for reinnervation have been developed for preventing muscle atrophy, clinical indications and effectiveness are limited because it is sometimes difficult to perform neurorrhaphy with appropriate nerve matching . Even after adequate nerve repair, some degree of muscle atrophy inevitably occurs.…”

The Effect of Collagen Nerve Conduits Filled with Collagen-Glycosaminoglycan Matrix on Peripheral Motor Nerve Regeneration in a Rat Model

“…A 10-mm segment of the sciatic nerve was excised with sharp microsurgical scissors under an operating microscope. The mean length of the rat sciatic nerve from the sciatic notch to the bifurcation point has been reported to be 19.8 mm (range, 15 to 23 mm; standard error of the mean, 2.8 mm) 14 . The resected segment of 10 mm thus represents approximately 50% of the whole sciatic nerve in the rat.…”