iPSC-derived megakaryocytes and platelets accelerate wound healing and angiogenesis.
Kentaro Kosaka,
Naoya Takayama,
Sudip Kumar Paul
et al.
Abstract:Background Platelet-rich plasma (PRP), which is prepared by concentrating platelets in autologous blood, shows efficacy in chronic skin wounds via multiple growth factors. However, it exhibits heterogeneity across patients, leading to unstable therapeutic efficacy. Human induced pluripotent stem cell (iPSC)-derived megakaryocytes and platelets (iMPs) are capable of providing a stable supply, holding promise as materials for novel platelet concentrate-based therapies. In this context, we evaluated the effect of… Show more
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