iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review

Csöbönyeiová, Mária; Polák, Štefan; Zamborský, Radoslav; Danišovič, Ľuboš

doi:10.1016/j.jare.2017.02.004

Cited by 61 publications

(45 citation statements)

References 65 publications

(56 reference statements)

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“…iPSCs exhibit advantages of mesenchymal stem cells and ESCs as they can differentiate to bone forming cells as osteoblasts or osteoclasts to enhance the bone regeneration. There is no doubt that iPSC would mark a major step forward in skeletal tissue engineering by successful clinical translation of tissue‐engineered solutions into surgical practice (Al‐Himdani et al, ; Csobonyeiova, Polak, Zamborsky, & Danisovic, ; De Peppo et al, ; Palomo et al, ; Phillips et al, ).…”

Section: Discussionmentioning

confidence: 99%

Induced pluripotent stem cells (iPSCs) as a new source of bone in reconstructive surgery: A systematic review and meta-analysis of preclinical studies

Fliefel

Ehrenfeld

Otto

2018

J Tissue Eng Regen Med

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It is now well established that regenerative medicine and stem cell therapy are the most promising approach to obtain full tissue regeneration by using various cell types including stem cells isolated from adult tissues, embryonic stem cells, and induced pluripotent stem cells (iPSCs). Recently, iPSCs have been successfully differentiated into osteoprogenitors to facilitate repair and regeneration of bone defects. Thus, the purpose of this systematic review and meta-analysis is to summarize the articles published that assess the osteogenic potential of iPSCs in vitro and their ability to heal bone defects in reconstructive surgery. PICO questions were subjected to literature search in four different databases. Methodological and risk of bias assessment of the included in vitro and in vivo articles were performed. Grading of Recommendations Assessment, Development, and Evaluation approach was used to assess the quality of evidence for each outcome variable included in the systematic review. In vivo bone formation was selected as the primary outcome for meta-analysis, and publication bias was explored using funnel plots. Initial literature search retrieved 4,772 studies, whereas only 70 articles included in the review. Yamanaka set was the commonly used reprogramming factor introduced with different vectors into the somatic cells. Several somatic cell sources have been used to successfully produce the iPSCs. iPSCs have osteogenic differentiation capacities and would be considered as a new source of stem cells that can be used in reconstructive surgery for bone regeneration.

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Section: Discussionmentioning

confidence: 99%

Induced pluripotent stem cells (iPSCs) as a new source of bone in reconstructive surgery: A systematic review and meta-analysis of preclinical studies

Fliefel

Ehrenfeld

Otto

2018

J Tissue Eng Regen Med

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“…The development of iPSCs is the intelligent way to have the advantages as well as remove the disadvantages of ESCs. After being introduced by Professor Shinya Yamanaka, more attention has been paid to use hiPSc for repair of bone diseases and damages [372]. Some studies clarified that these cells are comparable in vivo bone regeneration and angiogenic capability to hBMSCs and hUCMSCs on rats [373].…”

Section: The Future-where Are We Going?mentioning

confidence: 99%

Bone Tissue Engineering Using Human Cells: A Comprehensive Review on Recent Trends, Current Prospects, and Recommendations

et al. 2019

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The use of proper cells for bone tissue engineering remains a major challenge worldwide. Cells play a pivotal role in the repair and regeneration of the bone tissue in vitro and in vivo. Currently, a large number of differentiated (somatic) and undifferentiated (stem) cells have been used for bone reconstruction alone or in combination with different biomaterials and constructs (e.g., scaffolds). Although the results of the cell transplantation without any supporting or adjuvant material have been very effective with regard to bone healing. Recent advances in bone scaffolding are now becoming new players affecting the osteogenic potential of cells. In the present study, we have critically reviewed all the currently used cell sources for bone reconstruction and discussed the new horizons that are opening up in the context of cell-based bone tissue engineering strategies.

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“…Induced pluripotent stem cells (iPSCs) are adult cells that have been reprogrammed using embryonic transcription factors to become pluripotent . Like ASCs, iPSCs circumvent the ethical issues of embryonic stem cells (ESCs), and their pluripotency makes them a promising candidate for cartilage and bone repair . The first human clinical trials using iPSCs are currently underway to treat macular degeneration .…”

Section: Stem Cell Therapy Bone Marrow Concentrate Lipoaspirate Anmentioning

confidence: 99%

“…118 Like ASCs, iPSCs circumvent the ethical issues of embryonic stem cells (ESCs), and their pluripotency makes them a promising candidate for cartilage and bone repair. [119][120][121][122] The first human clinical trials using iPSCs are currently underway to treat macular degeneration. 123 Moreover, iPSCs are the focus of research for other conditions, such as Alzheimer's, 124 Parkinson's, 125 and cardiovascular disease.…”

Section: Sources Of Stem Cells and Their Therapeutic Potentialmentioning

confidence: 99%

Current perspectives on biological approaches for osteoarthritis

Whitney

Liebowitz

Bolia

et al. 2017

Annals of the New York Academy of Sciences

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Musculoskeletal injuries that disrupt the structure and function of diarthrodial joints can cause permanent biomechanical alterations and lead to a more severe, chronic condition. Despite advancements that have been made to restore tissue function and delay the need for joint replacement, there are currently no disease-modifying therapies for osteoarthritis (OA). To reduce the risk of OA, innovative preventive medicine approaches have been developed over the last decade to treat the underlying pathology. Several biological approaches are promising treatment modalities for various stages of OA owing to their minimally invasive nature and actively dynamic physiological mechanisms that attenuate tissue degradation and inflammatory responses. Individualized growth factor and cytokine therapies, tissue-engineered biomaterials, and cell-based therapies have revolutionary potential for orthopedic applications; however, the paucity of standardization and categorization of biological components and their counterparts has made it difficult to determine their clinical and biological efficacy. Cell-based therapies and tissue-engineered biologics have become lucrative in sports medicine and orthopedics; nonetheless, there is a continued effort to produce a biological treatment modality tailored to target intra-articular structures that recapitulates tissue function. Advanced development of these biological treatment modalities will potentially optimize tissue healing, regeneration, and joint preservation strategies. Therefore, the purpose of this paper is to review current concepts on several biological treatment approaches for OA.

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iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review

Abstract: Graphical abstract

Cited by 61 publications

References 65 publications

Induced pluripotent stem cells (iPSCs) as a new source of bone in reconstructive surgery: A systematic review and meta-analysis of preclinical studies

Induced pluripotent stem cells (iPSCs) as a new source of bone in reconstructive surgery: A systematic review and meta-analysis of preclinical studies

Bone Tissue Engineering Using Human Cells: A Comprehensive Review on Recent Trends, Current Prospects, and Recommendations

Current perspectives on biological approaches for osteoarthritis

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