Ipomoea Muelleri Intoxication of Sheep in Western Australia

Gardiner, M. R.; Royce, R.; Oldroyd, Benjamin P.

doi:10.1016/s0007-1935(17)41154-7

Cited by 22 publications

(12 citation statements)

References 3 publications

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“…Such observations pertaining to locomotive disturbances were also reported in sheep which had consumed Ipornoeu rnucllcri (Gardiner et al 1965) The results suggest that neuromuscular blockade might play a role in the manifestation of locomotive disturbances exhibited in goats ingesting the plant Ipomoeujistulosa whose botanical identification has shown it to be identical with the so-called Ipornoea carnea referred to by Idris ef al. (1973).…”

Section: Discussionsupporting

confidence: 69%

“…Idris et al (1 973) have reported on the general weakness, tremors and paresis of the hind limbs of goats chronically fed on the fresh leaves of Ipomoea carnea. Such observations pertaining to locomotive disturbances were also reported in sheep which had consumed Ipornoeu rnucllcri (Gardiner et al 1965) but neither of these studies showed if this muscular weakness was a consequence of effects at the skeletal neuromuscular junction. In fact, Adam et al (1 973) ascribed the nervous signs in the goats and sheep to hepatic damage.…”

Section: Resultsmentioning

confidence: 87%

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NEUROMUSCULAR BLOCKING ACTIVITY OF A CRUDE AQUEOUS EXTRACT OF IPOMOEA FISTULOSA

Abdelhadi

Elkheir

Hassan

et al. 1986

Clin Exp Pharma Physio

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The rat phrenic nerve hemidiaphragm and chick biventer-cervicis preparations were used to investigate the effect of a crude aqueous extract of Ipomoea fistulosa. Electrically-induced skeletal muscle twitches of the hemidiaphragm were blocked by the extract and by tubocurarine. The anticholinesterase, physostigmine, intensified the blockade by the extract. The extract produced contracture of the chick biventer-cervicis preparation. It is suggested that the extract possesses neuromuscular blocking activity of a depolarizing nature.

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Section: Discussionsupporting

confidence: 69%

Section: Resultsmentioning

confidence: 87%

NEUROMUSCULAR BLOCKING ACTIVITY OF A CRUDE AQUEOUS EXTRACT OF IPOMOEA FISTULOSA

Abdelhadi

Elkheir

Hassan

et al. 1986

Clin Exp Pharma Physio

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“…(Schardl et al 2013b), there is reason to suspect these other compounds occur in at least some of the species considered here. For example there is a report of tremorgenic symptoms in livestock that have consumed I. muelleri (Gardiner et al 1965), consistent with symptoms caused by indole-diterpene alkaloids. Indeed Schardl et al…”

Section: Discussionmentioning

confidence: 88%

Phylogenetic and chemotypic diversity of Periglandula species in eight new morning glory hosts (Convolvulaceae)

Beaulieu

Panaccione²,

Ryan

et al. 2015

Mycologia

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Periglandula ipomoeae and P. turbinae (Ascomycota, Clavicipitaceae) are recently described fungi that form symbiotic associations with the morning glories (Convolvulaceae) Ipomoea asarifolia and Turbina corymbosa, respectively. These Periglandula species are vertically transmitted and produce bioactive ergot alkaloids in seeds of infected plants and ephemeral mycelia on the adaxial surface of young leaves. Whether other morning glories that contain ergot alkaloids also are infected by Periglandula fungi is a central question. Here we report on a survey of eight species of Convolvulaceae (Argyreia nervosa, I. amnicola, I. argillicola, I. gracilis, I. hildebrandtii, I. leptophylla, I. muelleri, I. pes-caprae) for ergot alkaloids in seeds and associated clavicipitaceous fungi potentially responsible for their production. All host species contained ergot alkaloids in four distinct chemotypes with concentrations of 15.8-3223.0 μg/g. Each chemotype was a combination of four or five ergot alkaloids out of seven alkaloids detected across all hosts. In addition, each host species exhibited characteristic epiphytic mycelia on adaxial surfaces of young leaves with considerable interspecific differences in mycelial density. We sequenced three loci from fungi infecting each host: the nuclear rDNA internal transcribed spacer region (ITS), introns of the translation factor 1-α gene (tefA) and the dimethylallyl-tryptophan synthase gene (dmaW), which codes for the enzyme that catalyzes the first step in ergot alkaloid biosynthesis. Phylogenetic analyses confirmed that these fungi are in the family Clavicipitaceae and form a monophyletic group with the two described Periglandula species. This study is the first to report Periglandula spp. from Asian, Australian, African and North American species of Convolvulaceae, including host species with a shrub growth form and host species occurring outside of the tropics. This study demonstrates that ergot alkaloids in morning glories always co-occur with Periglandula spp. and that closely related Periglandula spp. produce alkaloid chemotypes more similar than more distantly related species.

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“…Grazing on morning glories, most frequently on Ipomoea asarifolia and Ipomoea muelleri , may also cause a tremorgenic syndrome on livestock (Gardiner et al 1965; Medeiros et al 2003; Dorling et al 2004; Carvalho de Lucena et al 2014). This toxicosis is also associated with the presence of IDTs (Lee et al 2017), produced by seed-transmitted endophytic fungi, most likely P. ipomoeae (Schardl et al 2013; Lee et al 2017).…”

Section: Idts As Threats To Agriculture Public Health and The Fermementioning

confidence: 99%

Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications

Kozák

Szilágyi

Tóth

et al. 2019

Appl Microbiol Biotechnol

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Indole-diterpenes (IDTs) such as the aflatrems, janthitrems, lolitrems, paspalitrems, penitrems, shearinines, sulpinines, and terpendoles are biogenetically related but structurally varied tremorgenic and neurotoxic mycotoxins produced by fungi. All these metabolites derive from the biosynthetic intermediate paspaline, a frequently occurring IDT on its own right. In this comprehensive review, we highlight the similarities and differences of the IDT biosynthetic pathways that lead to the generation of the main paspaline-derived IDT subgroups. We survey the taxonomic distribution and the regulation of IDT production in various fungi and compare the organization of the known IDT biosynthetic gene clusters. A detailed assessment of the highly diverse biological activities of these mycotoxins leads us to emphasize the significant losses that paspaline-derived IDTs cause in agriculture, and compels us to warn about the various hazards they represent towards human and livestock health. Conversely, we also describe the potential utility of these versatile molecules as lead compounds for pharmaceutical drug discovery, and examine the prospects for their industrial scale manufacture in genetically manipulated IDT producers or domesticated host microorganisms in synthetic biological production systems.

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Ipomoea Muelleri Intoxication of Sheep in Western Australia

Cited by 22 publications

References 3 publications

NEUROMUSCULAR BLOCKING ACTIVITY OF A CRUDE AQUEOUS EXTRACT OF IPOMOEA FISTULOSA

NEUROMUSCULAR BLOCKING ACTIVITY OF A CRUDE AQUEOUS EXTRACT OF IPOMOEA FISTULOSA

Phylogenetic and chemotypic diversity of Periglandula species in eight new morning glory hosts (Convolvulaceae)

Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications

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