IPN’s of acrylic acid and N-isopropylacrylamide by gamma and electron beam irradiation

Burillo, Guillermina; Briones, M.; Adem, E.

doi:10.1016/j.nimb.2007.08.033

Cited by 23 publications

(10 citation statements)

References 9 publications

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“…So far, several strategies have been proposed in attempts to improve the response rate of PNIPAAm hydrogels, including introducing other monomer to modify the microstructure to form an interpenetrating network (IPN) 7–9, 12–19. An IPN is formed when a second hydrogel network is polymerized within a prepolymerized hydrogel.…”

Section: Introductionmentioning

confidence: 99%

Novel poly(N‐isopropylacrylamide)/clay/poly(acrylamide) IPN hydrogels with the response rate and drug release controlled by clay content

Jiang

Liu

et al. 2008

J Polym Sci B Polym Phys

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Novel interpenetrating network (IPN) hydrogels (PNIPAAm/clay/PAAm hydrogels) based on poly(N-isopropylacrylamide) (PNIPAAm) crosslinked by inorganic clay and poly(acrylamide) (PAAm) crosslinked by organic crosslinker were prepared in situ by ultraviolet (UV) irradiation polymerization. The effects of clay content on temperature dependence of equilibrium swelling ratio, deswelling behavior, thermal behavior, and the interior morphology of resultant IPN hydrogels were investigated with the help of Fourier transform infrared spectroscopy, differential scanning calorimeter (DSC), scanning electron microscope (SEM). Study on temperature dependence of equilibrium swelling ratio showed that all IPN hydrogels exhibited temperature-sensitivity. DSC further revealed that the temperature-sensitivity was weakened with increasing amount of clay. Study on deswelling behavior revealed that IPN hydrogels had much faster response rate when comparing with PNIPAAm/ clay hydrogels, and the response rate of IPN hydrogels could be controlled by clay content. SEM revealed that there existed difference in the interior morphology of IPN hydrogels between 20 [below lower critical solution temperature (LCST)] and 50 C (above LCST), and this difference would become obvious with a decrease in clay content. For the standpoint of applications, oscillating swelling/deswelling behavior was investigated to determine whether properties of IPN hydrogels would be stable for potential applications. Bovine serum albumin (BSA) was used as model drug for in vitro experiment, the release data suggested that the controlled drug release could be achieved by modulating clay content. V V C 2008 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: [96][97][98][99][100][101][102][103][104][105][106] 2009

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Section: Introductionmentioning

confidence: 99%

Novel poly(N‐isopropylacrylamide)/clay/poly(acrylamide) IPN hydrogels with the response rate and drug release controlled by clay content

Jiang

Liu

et al. 2008

J Polym Sci B Polym Phys

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“…Ionizing radiation-induced polymerization is an economical, clean, and convenient technique for the synthesis, grafting or modification of biomaterials [94]- [97]. Ionizing radiation (gamma radiation, electron beam or X-ray) allow the creation of interesting polymers with new architectures.…”

Section: Smart Polymersmentioning

confidence: 99%

“…Specifically, the use of gamma radiation has some advantages including the possibility to perform grafting at room temperature in solid, liquid or gaseous state, no need of additives (catalyst or initiators), high penetrability, much higher grafting yields if compared to electron beam radiation, and surface selectivity by tuning reaction conditions, etc. Burillo et al [97] prepared a temperature and pH-responsive interpenetrating network by gamma radiation from a 60 Co gamma source and electron beam using a Van de Graaff accelerator. Interpenetrating networks of temperature sensitive PNIPAAm and pH sensitive PAAc were prepared by two consecutive steps.…”

Section: Smart Polymersmentioning

confidence: 99%

Smart Polymers and Coatings Obtained by Ionizing Radiation: Synthesis and Biomedical Applications

Meléndez‐Ortiz¹,

Varca²,

Lugão³

et al. 2015

OJPChem

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Gamma radiation has been shown particularly useful for the functionalization of surfaces with stimuli-responsive polymers. This method involves the formation of active sites (free radicals) onto the polymeric backbone as a result of the exposition to high-energy radiation, in which a proper microenvironment for the reaction among monomer and/or polymer and the active sites takes place, thus leading to propagation which forms side chain grafts. The modification of polymers using high-energy irradiation may be performed by the following methods: direct or simultaneous, pre-irradiation oxidative and pre-irradiation. The most frequent ones correspond to the pre-irradiation oxidative method and the direct one. Radiation-grafting has many advantages over conventional methods considering that it does not require catalyst nor additives to initiate the reaction, and in general, no changes on the mechanical properties with respect to the pristine polymeric matrix are observed. This chapter focused on the synthesis of smart polymers and coatings obtained by the use of gamma radiation. In addition, diverse applications of these materials in the biomedical field are also reported.

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“…It has been reported that PAA can be employed as protein-resistive hydrogel material [37,38] and bioadhesive devices due to its high adhesive bond strength, flexibility and non-abrasive characteristics in the partially swollen state [39][40][41]. During the past decade, there has been ample literature on the modification of PNIPAAm hydrogels with PAA [43][44][45][46][47][48][49][50][51][52][53][54][55][56]. The approaches to introduce acrylic acid are generally divided into two categories: (i) random co-polymerization of NIPAAm with acrylic acid [43][44][45][46][47][48] and (ii) formation of interpenetrating polymer networks composed of PNIPAAm and PAA [50][51][52][53][54][55][56].…”

Section: Introductionmentioning

confidence: 99%

Poly(acrylic acid)-grafted Poly(N-isopropyl acrylamide) Networks: Preparation, Characterization and Hydrogel Behavior

Zheng

2011

Journal of Biomaterials Science, Polymer Edition

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Poly(acrylic acid)-grafted poly(N-isopropylacrylamide) co-polymer networks (PNIPAAm-g-PAA) were prepared via the reversible addition-fragmentation transfer (RAFT) polymerization of N-isopropyl- acrylamide (NIPAAm) with trithiocarbonate-terminated PAA as a macromolecular chain-transfer agent in the presence of N,N-methylenebisacrylamide. The PNIPAAm-g-PAA co-polymer networks were characterized by means of Fourier transform infrared spectroscopy, differential scanning calorimetry and small-angle X-ray scattering. It is found that the PNIPAAm-g-PAA co-polymer networks were microphase-separated, in which the microdomains of PNIPAAm-PAA interpolymer complexes were dispersed into the PNIPAAm matrix. The PNIPAAm-g-PAA hydrogels displayed a dual response to temperature and pH values. The thermoresponsive properties of PNIPAAm-g-PAA networks were investigated. Below the volume phase transition temperatures, the PNIPAAm-g-PAA hydrogels possessed much higher swelling ratios than control PNIPAAm hydrogel. In terms of swelling, deswelling and reswelling tests, it is judged that the PNIPAAm-g-PAA hydrogels displayed faster response to the external temperature changes than control PNIPAAm hydrogel. The improved thermoresponsive properties of hydrogels are ascribed to the formation of PAA-grafted PNIPAAm networks, in which the water-soluble PAA chains behave as the hydrophiphilic tunnels and allow water molecules to go through and, thus, to accelerate the diffusion of water molecules.

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IPN’s of acrylic acid and N-isopropylacrylamide by gamma and electron beam irradiation

Cited by 23 publications

References 9 publications

Novel poly(N‐isopropylacrylamide)/clay/poly(acrylamide) IPN hydrogels with the response rate and drug release controlled by clay content

Novel poly(N‐isopropylacrylamide)/clay/poly(acrylamide) IPN hydrogels with the response rate and drug release controlled by clay content

Smart Polymers and Coatings Obtained by Ionizing Radiation: Synthesis and Biomedical Applications

Poly(acrylic acid)-grafted Poly(N-isopropyl acrylamide) Networks: Preparation, Characterization and Hydrogel Behavior

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