Ipecac root extracts and isolated circular peptides differentially suppress inflammatory immune response characterised by proliferation, activation and degranulation capacity of human lymphocytes in vitro

Falanga, Chiara Madlen; Steinborn, Carmen; Muratspahić, Edin; Zimmermann-Klemd, Amy Marisa; Winker, Moritz; Krenn, Liselotte; Huber, Roman; Gruber, Christian W.; Gründemann, Carsten

doi:10.1016/j.biopha.2022.113120

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…Willd.) ipecacuanha, poaia 104 Not mentioned Native Emetic, expectorant, diaphoretic (sudorific) Expectorant † [ 131 ], emetic † [ 132 , 133 ], immunomodulatory [ 134 ] Genipa americana L. (= Genipa brasiliensis (Sprend.) Baill) jenipapo 106 Fruit Native Medicinal (undefined) Antiplatelet, anti-inflammatory [ 135 ]; neuroprotective [ 136 ]; antioxidant, anti-glycant [ 137 ]; antithrombotic [ 138 ]; anticonvulsant [ 139 ]; trypanocidal [ 140 ] Sapindaceae Paullinia cupana Kunth.…”

Section: Resultsmentioning

confidence: 99%

Amazonian useful plants described in the book “Le Pays des Amazones” (1885) of the Brazilian propagandist Baron de Santa-Anna Nery: a historical and ethnobotanical perspective

Silva,

Oliveira,

Baratto

2024

J Ethnobiology Ethnomedicine

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Background Frederico José de Santa-Anna Nery (1848–1901) was a Brazilian Baron who referred to himself as a "volunteer propagandist" for Brazil in Europe, serving as an immigration agent to publicize the living conditions in the Amazon region, advocating for its development and modernization at the end of the nineteenth century. Santa-Anna Nery’s most famous book is "Le Pays des Amazones" (The Lands of the Amazons), first published in 1885, which the author dedicated a chapter to introduce and report on the Amazonian useful plant species and its relationship with humans. The aim of this work is to understand the historical context and ethnobotanical value of the plant species in the Brazilian Amazon at the end of the nineteenth century through an analysis of the book “Le Pays des Amazones” (1885) by Baron de Santa-Anna Nery, as well as to bring to light the historical importance of this very influential propagandist, who has been forgotten nowadays. Methods The original book “Le Pays des Amazones” (1885), as well as the original 3rd edition and its translated version into Portuguese, was carefully analyzed and all information about plants was systematized, with botanical names being updated. Finally, using the scientific name of medicinal plants alone or in combination with their traditional use, a search was carried out in databases in order to indicate current pharmacological studies that provide evidence about the described traditional uses. Results A total of 156 plant species were identified in the book, although 132 species had their scientific names updated. These species belong to 45 different families, with Fabaceae and Arecaceae the most represented, and 109 plants are Brazilian native. Considering only the 36 medicinal plants, the main medicinal indications reported were astringent, purgative/laxative, stimulant and tonic, vermifuge, febrifuge, sudorific, emetic, diuretic and antidysenteric. Regarding other useful plants (non-medicinal), 97 species were cited for food, constructions and buildings, spices and condiments, ornaments and objects, carpentry, textile fibers, gums, oils, balms and essences, pigments and tanning, hunting and fishing. Conclusions When the book “Le Pays des Amazones” is analyzed from a timeless perspective, with a particular focus on historical ethnobotany, it is possible to observe the economic, social, and political importance of many useful plants for the Amazon at the end of the nineteenth century and how the relationship between local people, indigenous communities, and immigrants was established with plant biodiversity.

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Section: Resultsmentioning

confidence: 99%

Amazonian useful plants described in the book “Le Pays des Amazones” (1885) of the Brazilian propagandist Baron de Santa-Anna Nery: a historical and ethnobotanical perspective

Silva,

Oliveira,

Baratto

2024

J Ethnobiology Ethnomedicine

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“…Interestingly, cyclotides mutated in a hydrophilic inter-cysteine loop 1 and 2 region lost their activity, while the active ones acted antiproliferative by reducing the expression of the interleukin (IL)-2 surface receptor and IL-2 cytokine secretion 8 . Recently, an anti-inflammatory function of ipecac root extracts and ipecac cyclotides was reported 9 . The immunomodulatory functions of cyclotides were also shown in vivo , namely, in the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis 10 .…”

Section: Introductionmentioning

confidence: 99%

Exploring Immune Modulatory Effects of Cyclotide-Enriched Viola tricolor Preparations

Retzl,

Zimmermann-Klemd,

Gründemann

et al. 2023

Planta Med

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Viola tricolor is a medicinal plant with documented application as an anti-inflammatory herb. The standard of care for the treatment of inflammatory bowel disease is immunosuppressive therapeutics or biologics, which often have undesired effects. We explored V. tricolor herbal preparations that are rich in an emerging class of phytochemicals with drug-like properties, so-called cyclotides. As an alternative to existing inflammatory bowel disease medications, cyclotides have immunomodulatory properties, and their intrinsic stability allows for application in the gastrointestinal tract, for instance, via oral administration. We optimized the isolation procedure to improve the yield of cyclotides and compared the cellular effects of violet-derived organic solvent-extracts, aqueous preparations, and an isolated cyclotide from this plant on primary human T lymphocytes and macrophages, i.e., cells that are crucial for the initiation and progression of inflammatory bowel disease. The hot water herbal decoctions have a stronger immunosuppressive activity towards proliferation, interferon-γ, and interleukin-21 secretion of primary human T cells than a DCM/MeOH cyclotide-enriched extract, and the isolated cyclotide kalata S appears as one of the active components responsible for the observed effects. This effect was increased by a longer boiling duration. In contrast, the DCM/MeOH cyclotide-enriched extract was more effective in reducing the levels of cytokines interleukin-6, interleukin-12, interleukin-23, tumor necrosis factor-α, and C – X-C motif chemokine ligand 10, secreted by human monocyte-derived macrophages. Defined cyclotide preparations of V. tricolor have promising pharmacological effects in modulating immune cell responses at the cytokine levels. This is important towards understanding the role of cyclotide-containing herbal drug preparations for future applications in immune disorders, such as inflammatory bowel disease.

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Immunosuppressive Cyclotides: A Promising Approach for Treating Autoimmune Diseases

Huynh,

Ho,

Pham

et al. 2024

Protein J

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Ipecac root extracts and isolated circular peptides differentially suppress inflammatory immune response characterised by proliferation, activation and degranulation capacity of human lymphocytes in vitro

Cited by 4 publications

References 34 publications

Amazonian useful plants described in the book “Le Pays des Amazones” (1885) of the Brazilian propagandist Baron de Santa-Anna Nery: a historical and ethnobotanical perspective

Amazonian useful plants described in the book “Le Pays des Amazones” (1885) of the Brazilian propagandist Baron de Santa-Anna Nery: a historical and ethnobotanical perspective

Exploring Immune Modulatory Effects of Cyclotide-Enriched Viola tricolor Preparations

Immunosuppressive Cyclotides: A Promising Approach for Treating Autoimmune Diseases

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