IPEADAM study: Indoor endotoxin exposure, family status, and some housing characteristics in English children

Tavernier, G; Fletcher, Gillian; Gee, Ivan; Watson, A.F.R.; Blacklock, G.; Francis, Helen; Fletcher, A. M.; Frank, Timothy L; Pi, Felip; Pickering, C. A. C.; Niven, Robert

doi:10.1016/j.jaci.2005.12.1311

Cited by 73 publications

(59 citation statements)

References 41 publications

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“…In a cohort of 1,884 German newborns, a two-fold increased risk of wheezing during the first 6 months of life was found in children exposed to high endotoxin concentrations (OR 2.37, 95% CI 1.40-4.03) [78]. Such associations have been confirmed in other longitudinal studies [79,80,84], as well as in case-control or crosssectional studies [81][82][83]. Moreover, exposure to endotoxins has been linked to asthma severity and morbidity [86,87].…”

Section: Endotoxinsmentioning

confidence: 66%

“…Findings from epidemiological studies are less consistent [74]. Whereas some reports suggest a protective effect of endotoxins on the development of allergies [57,[75][76][77], others found that the exposure to endotoxins constitutes a risk factor for respiratory symptoms [78][79][80][81][82][83][84], which might depend on the amount of exposure [85].…”

Section: Endotoxinsmentioning

confidence: 99%

“…The first studies that evaluated the respiratory effects of endotoxin exposure in an urban environment observed positive associations with asthma and wheezing [78][79][80][81][82][83][84]. In a cohort of 1,884 German newborns, a two-fold increased risk of wheezing during the first 6 months of life was found in children exposed to high endotoxin concentrations (OR 2.37, 95% CI 1.40-4.03) [78].…”

Section: Endotoxinsmentioning

confidence: 99%

“…Several cross-sectional studies showed an increased risk of asthma with high exposure to indoor formaldehyde [3,[125][126][127], whereas some did not find any significant result [33,83,128]. The first longitudinal study on the respiratory effects of indoor formaldehyde found a significant positive association between formaldehyde concentration and incidence of asthma diagnosis (OR 1.7, 95% CI 1.1-2.6, for each formaldehyde increment of 10 mg?m ), but only among non-atopic children [69].…”

Section: Formaldehyde and Vocsmentioning

confidence: 99%

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Respiratory health and indoor air pollutants based on quantitative exposure assessments

et al. 2012

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We reviewed the main epidemiological studies that evaluate the respiratory effects of indoor air pollutants quantitatively in industrialised countries. Consistent results support short-term (aggravation) and, although more rarely, long-term (prevalence augmentation) effects on asthma, chronic bronchitis and chronic obstructive pulmonary disease (COPD) in indoor settings with poor air quality. Environmental tobacco smoke is one of the most important risks for respiratory symptoms and diseases worldwide. The evidence is also reliable for indoor nitrogen dioxide and particulate matter, which have been associated with asthma, bronchitis and COPD. Whereas formaldehyde and volatile organic compounds seem to be the main pollutants in indoor settings, relevant papers on their respiratory effects are still scarce, and limited to asthma and bronchitis. Moulds have been associated with an increased risk of asthma and COPD. Contradictory results have been found between endotoxins and asthma. The role of phthalates, persistent organic pollutants and flame retardants in respiratory diseases remains to be established. Results from rural areas of industrialised countries indicate that exposure to some indoor bio-contaminants might be protective in early life, while it is associated with adverse respiratory adverse effects in adulthood. Studies focusing on indoor air pollutants should be developed to better understand their involvement in the inception and aggravation of respiratory diseases.

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Section: Endotoxinsmentioning

confidence: 66%

Section: Endotoxinsmentioning

confidence: 99%

Section: Endotoxinsmentioning

confidence: 99%

Section: Formaldehyde and Vocsmentioning

confidence: 99%

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Respiratory health and indoor air pollutants based on quantitative exposure assessments

et al. 2012

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“…Endotoxin is a cell wall component of the outer membrane of Gram-negative bacteria and is present in indoor environments as constituents of house dust. In homes, endotoxin has been linked to decreased rates of sensitisation, asthma and hay fever in early childhood [14][15][16], but endotoxin is also associated with increased symptom prevalence and nonallergic asthma [14,17]. In most studies, endotoxin in schools was studied in a small number of measurements, and endotoxin was mainly measured in floor dust [6,[8][9][10][11], which is a poor proxy of inhalatory endotoxin exposure, as the majority of classroom floor dust consists of large and heavy particles (sand and breadcrumbs).…”

Section: Introductionmentioning

confidence: 99%

Endotoxin levels in homes and classrooms of Dutch school children and respiratory health

et al. 2012

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Several studies describe indoor pollutant exposure in homes and to a lesser extent in schools. Population studies that include both environments are sparse. This study aims to assess endotoxin levels in primary schools and homes of children. Endotoxin was also studied in relation to asthma and sensitisation.10 schools with (index) and without (reference) dampness were selected, based on reports and inspections. Cases and controls were selected from 169 homes based on the presence or absence of asthmalike symptoms of children. Classroom and bedroom airborne settled dust was sampled using electrostatic dust fall collectors.Average endotoxin levels in schools ranged from 2178 to 6914 endotoxin units (EU)?m -2 per week compared with 462-1285 EU?m -2 per week in homes. After mutual adjustment for home and school endotoxin, school endotoxin was positively associated with nonatopic asthma (OR 1.11, 95% CI 0.97-1.27), while no associations with endotoxin were found at home.The high endotoxin levels in schools compared with homes indicate that exposure at school can contribute considerably to environmental endotoxin exposure of children and teachers. Our results also suggest that endotoxin in schools may be associated with nonatopic asthmatic symptoms in pupils, although the results require reproduction because of the modest sample size. @ERSpublications School endotoxin levels can contribute to exposure of children and teachers, causing nonatopic asthmatic symptoms

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Association of Allergic Rhinitis in Female University Students with Socio-economic Factors and Markers of Estrogens Levels

Wronka

Kliś

Jarzebak

2015

Advances in Experimental Medicine and Biology

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The aim of this study is to investigate the association of allergic rhinitis in female university students with socio-economic factors and sex-hormone markers, including age at menarche, menstrual disorders, and selected anthropometrics indexes. The research was conducted among 640 female university students, aged 19-25 years. The measurements of body height, body mass, waist and hip circumference were taken. Each person completed a questionnaire. The occurrence of allergy was determined on the basis of answers to the questions whether the allergy and its allergens were defined on the basis of medical workup. We found that a significantly larger number of cases of allergic rhinitis were recorded in the university students coming from families of high socio-economic level than those from lower level. Allergic rhinitis also was more frequent in the students who spent their childhood in cities than in those who lived in the countryside. The prevalence of allergic rhinitis was inversely correlated to the number of siblings. There were no differences in the prevalence of allergic rhinitis in relation to the birth order. The estrogen level seemed unassociated with rhinitis. However, there were slightly more allergic among females with an earlier age of menarche.

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IPEADAM study: Indoor endotoxin exposure, family status, and some housing characteristics in English children

Cited by 73 publications

References 41 publications

Respiratory health and indoor air pollutants based on quantitative exposure assessments

Respiratory health and indoor air pollutants based on quantitative exposure assessments

Endotoxin levels in homes and classrooms of Dutch school children and respiratory health

Association of Allergic Rhinitis in Female University Students with Socio-economic Factors and Markers of Estrogens Levels

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