IOP Changes after DSEK

Prasanth, Baswati; Dubey, Suneeta; Mathur, Umang

doi:10.1016/j.ophtha.2010.03.021

Cited by 9 publications

(7 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In comparison to other studies our rate of steroid-induced glaucoma was low, with a total incidence of 7-8% [1,13,41]. The rate of steroid-induced glaucoma was probably underestimated in the PK group, with its high prevalence of pre-existing glaucoma.…”

Section: Discussioncontrasting

confidence: 75%

“…In detail, we found no statistically significant difference between DSEK and PK in the development of PAS for both indications, although DSEK was performed with small incisions, without sutures and with a maximum diameter of donor grafts of 8.5 mm to minimize the risk of postoperative angle distortion. However, other reasons like decentred graft, history of narrow angles, iridotomy/iridectomy before surgery, postoperative pupillary block glaucoma, or postoperative inflammation may be responsible for the development of PAS [41]. In our cases no decentred grafts and no history of narrow angles were apparent.…”

Section: Discussionmentioning

confidence: 62%

See 1 more Smart Citation

Anterior Segment Analysis and Intraocular Pressure Elevation after Penetrating Keratoplasty and Posterior Lamellar Endothelial Keratoplasty

et al. 2014

View full text Add to dashboard Cite

Background: Peripheral anterior synechiae (PAS) is a common problem after penetrating keratoplasty (PK) and leads to intraocular pressure (IOP) elevation. This study examines the risk factors for IOP elevation and post-keratoplasty glaucoma. Methods: A retrospective analysis was performed of 47 eyes following PK and of 65 eyes following Descemet's stripping endothelial keratoplasty (DSEK) between 2009 and 2011. The assessment included preoperative history of corneal disease and glaucoma, response to treatment, IOP, and visual acuity. Irido-trabecular contacts (ITC), the angle opening distance (AOD 500) and the anterior chamber angle (ACA 500) were calculated. Results: The incidences of IOP elevation and post-keratoplasty glaucoma were 27-36% and 10-29%, respectively. The incidence did not differ significantly between both procedures. Pre-existing glaucoma increased the risk for developing IOP elevation and post-DSEK glaucoma. Eyes with bullous keratopathy (BK) developed significantly more IOP elevation (p = 0.01, d.f. = 1, χ² = 6.11) and post-keratoplasty glaucoma (p = 0.01, d.f. = 1, χ² = 6.22) than eyes with Fuchs' endothelial dystrophy. Eyes with ITC developed post-keratoplasty glaucoma significantly more often than eyes without ITC (p = 0.01, d.f. = 1, χ² = 6.63). Conclusion: IOP elevation and post-keratoplasty glaucoma showed a high incidence. Risk factors like pre-existing glaucoma, BK and PAS elevated the rate of IOP elevation and post-keratoplasty glaucoma for both procedures. © 2014 S. Karger AG, Basel

show abstract

Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 62%

Anterior Segment Analysis and Intraocular Pressure Elevation after Penetrating Keratoplasty and Posterior Lamellar Endothelial Keratoplasty

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In another eye, preexisting open-angle glaucoma may have been aggravated into intermittent glaucomatous crises by the DMEK surgery, 17 possibly by peripheral anterior synechiae, perioperative inflammation, or the steroidal medication. 21 No other glaucomatous or posterior segment complications occurred in this series, nor did other graft-related problems, such as primary or secondary graft failure or allograft rejection. Therefore, because the latter cases might be considered incidental and mechanical angle-closure glaucoma can be avoided, DMEK in phakic eyes may be associated with a relatively low risk for complications.…”

Section: Discussionmentioning

confidence: 60%

Outcomes of Descemet membrane endothelial keratoplasty in phakic eyes

Parker

Dirisamer

Naveiras

et al. 2012

Journal of Cataract and Refractive Surgery

View full text Add to dashboard Cite

show abstract

“…Clinically, PAS is associated with chronic inflammation in the anterior chamber, a history of narrow angle, and breakdown of the blood–aqueous barrier (BAB) 35 ; however, the mechanism of PAS formation remains elusive. Previous studies have shown that pan-retinal photocoagulation 36 and diode laser trabeculoplasty 37 caused temporal increases in flare photon levels; however, they did not cause PAS formation.…”

Section: Discussionmentioning

confidence: 99%

Aqueous Cytokine Levels Are Associated With Progression of Peripheral Anterior Synechiae After Descemet Stripping Automated Endothelial Keratoplasty

Kusano

Yamaguchi

Nishisako

et al. 2021

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Purpose To evaluate the association between total protein and cytokine levels in aqueous humor (AqH) and the progression of peripheral anterior synechiae (PAS) after Descemet stripping automated endothelial keratoplasty (DSAEK). Methods This prospective study included 146 consecutive patients who underwent DSAEK. Preoperative levels of total protein and 20 cytokines in AqH were measured. Using three-dimensional anterior segment optical coherence tomography, we assessed the iridotrabecular contact (ITC) area before and at 3, 6, and 12 months after DSAEK. Correlations between the total protein and cytokine levels in the AqH and ITC area were analyzed. Results ITC was observed in 47 eyes (32.2%) after DSAEK. The ITC area increased from 2.00 ± 4.42 mm 2 preoperatively to 3.00 ± 6.85 mm 2 at 12 months. The total protein level in AqH was significantly higher in eyes with ITC progression than in those without (1.45 ± 1.03 mg/mL vs. 1.00 ± 0.57; P = 0.04) and was significantly positively correlated with the progression of ITC area after DSAEK (at 6 months, r = 0.311 and P = 0.005; at 12 months, r = 0.342 and P = 0.0004). The ITC area at 12 months was significantly correlated with the preoperative AqH levels of interleukin-8 ( r = 0.252; P = 0.021), interferon-γ ( r = 0.318; P = 0.009), and soluble intercellular adhesion molecule-1 ( r = 0.292; P = 0.004). Multivariate analyses showed that the total protein levels in AqH and the presence of preoperative ITC were significant risk factors for increased ITC area after DSAEK (β = 0.193–0.574; all P < 0.02). Conclusions Higher preoperative total protein and specific cytokine levels in AqH were associated with ITC formation after DSAEK. Translational Relevance Our findings indicate that chronic pathological changes in AqH can cause PAS progression and glaucoma after DSAEK.

show abstract

IOP Changes after DSEK

Cited by 9 publications

References 4 publications

Anterior Segment Analysis and Intraocular Pressure Elevation after Penetrating Keratoplasty and Posterior Lamellar Endothelial Keratoplasty

Anterior Segment Analysis and Intraocular Pressure Elevation after Penetrating Keratoplasty and Posterior Lamellar Endothelial Keratoplasty

Outcomes of Descemet membrane endothelial keratoplasty in phakic eyes

Aqueous Cytokine Levels Are Associated With Progression of Peripheral Anterior Synechiae After Descemet Stripping Automated Endothelial Keratoplasty

Contact Info

Product

Resources

About