Iontophoretic Delivery of Nonpeptide Drugs: Formulation Optimization for Maximum Skin Permeability

Sanderson, John E.; Riel, Stanton De; Dixon, Ross

doi:10.1002/jps.2600780504

Cited by 38 publications

(11 citation statements)

References 8 publications

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“…This implies that the iontophoretic transport of chemicals is influenced by the composition of the donor phase as well as the acceptor phase. In contrast to the donor phase, the effect of the composition in the acceptor phase has not been widely studied 14–16…”

Section: Introductionmentioning

confidence: 99%

Mechanistic studies of the transdermal iontophoretic delivery of 5-OH-DPAT in vitro

Ackaert

Smeden

Graan

et al. 2010

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Mechanistic studies of the transdermal iontophoretic delivery of 5-OH-DPAT in vitro

Ackaert

Smeden

Graan

et al. 2010

Journal of Pharmaceutical Sciences

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“…It was explainable because iontophoretic burns in skin are often produced after long-term application [Tyle, 1986]. Another published work also found that the current tends to block the sweat ducts that may result in the slight degeneration of skin appendages as shown in Figure 7(c) [Clancy et al, 1994;Sanderson et al, 1989]. In conclusion, these findings suggest that duration of iontophoretic application of not more than 7 h is suitable for transdermal drug delivery.…”

Section: Discussionmentioning

confidence: 73%

Transdermal iontophoresis of sodium nonivamide acetate evaluated by in vivo microdialysis and histologic study

et al. 1999

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“…But this is not the general observation since, an increase in concentration increases flux upto a point, after which the flux becomes independent of the donor concentration. This is probably due to the charge saturation of the aqueous conducting pathways of skin also called as boundary layer saturation [36]. Methyl phenidate showed a little change in flux when concentration was increased beyond 0.1M [37].…”

Section: Composition Of Formulationmentioning

confidence: 99%

Iontophoresis - An Approach for Controlled Drug Delivery: A Review

Dixit¹,

Bali²,

Baboota³

et al. 2007

curr drug deliv

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The recent approval of lidocaine hydrochloride and epinephrine combined iontophoretic patch (Lidosite ® Vysteris Inc.) for localized pain treatment by FDA has invigorated the gaining interest in iontophoretic drug delivery systems for the transdermal delivery of drugs. This technique of facilitated movement of ions across a membrane under the influence of an externally applied electric potential difference, is one of the most promising physical skin penetration enhancing method. The rationale behind using this technique is the capability of this method to increase the systemic delivery of high molecular weight compounds with controlled input kinetics and minimum inter-subject variability, which is otherwise achieved only when parentral route of administration is used. Recently, good permeation of larger peptides like insulin has been achieved through this technique in combination with chemical enhancers. This review briefly describes the factors which affect iontophoretic drug delivery and summarizes the studies conducted recently using this technique in order to achieve higher systemic absorption of the drugs having low passive diffusion otherwise. The effect of permeation enhancers (chemical enhancers) on iontophoretic flux of drugs has also been described. Present review also provides an insight into reverse iontophoresis. Various parameters which affect the transdermal absorption of drugs through iontophoresis like drug concentration, polarity of drugs, pH of donor solution, presence of co-ions, ionic strength, electrode polarity etc. have also been reviewed in detail.

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Iontophoretic Delivery of Nonpeptide Drugs: Formulation Optimization for Maximum Skin Permeability

Cited by 38 publications

References 8 publications

Mechanistic studies of the transdermal iontophoretic delivery of 5-OH-DPAT in vitro

Mechanistic studies of the transdermal iontophoretic delivery of 5-OH-DPAT in vitro

Transdermal iontophoresis of sodium nonivamide acetate evaluated by in vivo microdialysis and histologic study

Iontophoresis - An Approach for Controlled Drug Delivery: A Review

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