Iontophoresis: An overview of the mechanisms and clinical application

Li, Linda; Scudds, PT Roger A.

doi:10.1002/art.1790080111

Cited by 29 publications

(14 citation statements)

References 41 publications

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“…According to Kahn (71, iontophoresis is defined as "the introduction of substances into the body for therapeutic purposes by means of a 0893-7524/96/$5.00 direct current." The possible mechanisms of iontophoresis and its applications were recently described (8).…”

Section: Introductionmentioning

confidence: 99%

The efficacy of dexamethasone iontophoresis for the treatment of rheumatoid arthritic knees: A pilot study

Scudds

Heck

et al. 1996

Arthritis Care & Research

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Objective. To examine the efficacy of dexamethasone sodium phosphate (DEX) iontophoresis for the treatment of rheumatoid arthritis (RA) of the knee, and to obtain statistical information for a future randomized controlled trial (RCT). Methods. Ten subjects with RA, ranging in age from 34–75, were randomly assigned to either the experimental or placebo group. Iontophoresis treatments were given to both groups on days 1, 3, and 5. Five subjects in the experimental group received a mixture of 1 ml of DEX (4 mg/ml) and 1 ml of injectable sterile water; those in the placebo group received 2 ml of saline solution. Pain on movement, at rest, and on pressure, active joint count, and active range of motion, were evaluated on days 1, 5, and 20. The patient's global assessment of treatment efficacy was also assessed on days 5 and 20. Mann‐Whitney U tests and Friedman two‐way analyses of variance were performed for statistical analyses. Results. Pain at rest was found to be statistically different between the two groups (P = 0.0317). Statistical significance was also found over time for pain on movement within the experimental group (P = 0.0224). Conclusion. The results suggest that DEX iontophoresis is more effective than placebo in relieving pain at rest and on movement in the RA knee. Based on the study data, a total of 40 subjects will be required for an RCT of a similar nature.

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Section: Introductionmentioning

confidence: 99%

The efficacy of dexamethasone iontophoresis for the treatment of rheumatoid arthritic knees: A pilot study

Scudds

Heck

et al. 1996

Arthritis Care & Research

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“…However, methods are scarce that allow control of the number of ions delivered to a system. The established technique of ionotophoresis is based on electrophoretic ion transport, thus lending itself to drug delivery applications, such as transdermal administration of therapeutic agents [19][20][21]. However, precise spatio-temporal control is difficult to achieve in this system.…”

Section: Electronically Controlled Ion Transportmentioning

confidence: 99%

Organic Bioelectronic Tools for Biomedical Applications

2015

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Abstract:Organic bioelectronics forms the basis of conductive polymer tools with great potential for application in biomedical science and medicine. It is a rapidly growing field of both academic and industrial interest since conductive polymers bridge the gap between electronics and biology by being electronically and ionically conductive. This feature can be employed in numerous ways by choosing the right polyelectrolyte system and tuning its properties towards the intended application. This review highlights how active organic bioelectronic surfaces can be used to control cell attachment and release as well as to trigger cell signaling by means of electrical, chemical or mechanical actuation. Furthermore, we report on the unique properties of conductive polymers that make them outstanding materials for labeled or label-free biosensors. Techniques for electronically controlled ion transport in organic bioelectronic devices are introduced, and examples are provided to illustrate their use in self-regulated medical devices. Organic bioelectronics have great potential to become a primary platform in future bioelectronics. We therefore introduce current applications that will aid in the development of advanced in vitro systems for biomedical science and of automated systems for applications in neuroscience, cell biology and infection biology. Considering this broad spectrum of applications, organic bioelectronics could lead to timely detection of disease, and facilitate the use of remote and personalized medicine. As such, organic bioelectronics might contribute to efficient healthcare and reduced hospitalization times for patients. OPEN ACCESSElectronics 2015, 4 880

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“…The majority of the clinical studies utilise topical NSAIDs. 33 Physical factors are likely to be important in any delivery of these drugs. Kleinkort and Wood 34 state that the success of phonophoresis is proportional to the concentration of the drug in the cream applied.…”

Section: Phonophoresis: Possible Mechanismsmentioning

confidence: 99%

Phonophoresis of non-steroidal drugs: a review of the clinical evidence

Abrahams¹

2008

International Musculoskeletal Medicine

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Harrow, UKTherapeutic ultrasound is widely used for a variety of musculoskeletal pathologies and is the most common electrotherapy used in musculoskeletal practice. Phonophoresis is the use of ultrasound as a physical enhancer of percutaneous absorption of drugs. This review of the literature of basic research and clinical trials of these treatments finds limited evidence of efficacy for phonophoresis of anti-inflammatory drugs.

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Iontophoresis: An overview of the mechanisms and clinical application

Cited by 29 publications

References 41 publications

The efficacy of dexamethasone iontophoresis for the treatment of rheumatoid arthritic knees: A pilot study

The efficacy of dexamethasone iontophoresis for the treatment of rheumatoid arthritic knees: A pilot study

Organic Bioelectronic Tools for Biomedical Applications

Phonophoresis of non-steroidal drugs: a review of the clinical evidence

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