Ionomic profiling of pericardial fluid in ischemic heart disease

Khan, Niaz Ali; Hashmi, Satwat; Siddiqui, Amna Jabbar; Farooq, Sabiha; Sami, Shahid Ahmed; Basir, Nageeb; Bokhari, Syedah Saira; Sharif, Hasanat; Junejo, Sanaullah; Musharraf, Syed Ghulam

doi:10.1039/d0ra03977b

Cited by 3 publications

(2 citation statements)

References 52 publications

(48 reference statements)

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“…Ionomic technologies, such as ICP-MS, can measure and quantify elemental profiles to further analyze their variation. It has been applied into different tissue samples, such as canine hairs exposed to lipopolysaccharide (LPS)-induced stress, 58 pericardial fluid in ischemic heart disease, 59 and blood. 32 In the study, the ICP-MS technology was applied to test ionome levels in the spinal cord samples.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Ionomic Profiles of Spinal Cords in a Rat Model with Bone Cancer Pain

Huang,

Chen,

et al. 2024

JPR

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Background: Ionomics is used to study levels of ionome in different states of organisms and their correlations. Bone cancer pain (BCP) severely reduces quality of life of patients or their lifespan. However, the relationship between BCP and ionome remains unclear. Methods:The BCP rat model was constructed through inoculation of Walker 256 cells into the left tibia. Von Frey test, whole-cell patch-clamp recording and inductively coupled plasma mass spectrometry (ICP-MS) technologies were conducted for measuring tactile hypersensitivity, the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSCs) of neurons of spinal slices, and ionome of spinal cord samples, respectively. Principal component analysis (PCA) was used to explore ionomic patterns of the spinal cord. Results: The BCP rat model was successfully constructed through implantation of Walker 256 cells into the left tibia. The frequency and amplitude of mEPSCs of neurons in the spinal cord slices from the BCP model rats were notably greater than those in the sham control. In terms of ionomics, the spinal cord levels of two macroelements (Ca and S), four microelements (Fe, Mn, Li and Sr) and the toxic element Ti in the BCP group of rats were significantly increased by inoculation of Walker 256 cancer cells, compared to the sham control. In addition, the correlation patterns between the elements were greatly changed between the sham control and BCP groups. PCA showed that inoculation of Walker 256 cells into the tibia altered the overall ionomic profiles of the spinal cord. There was a significant separation trend between the two groups. Conclusion: Taken together, inoculation of Walker 256 cells into the left tibia contributes to BCP, which could be closely correlated by some elements. The findings provided novel information on the relationship between the ionome and BCP.

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Section: Discussionmentioning

confidence: 99%

Analysis of Ionomic Profiles of Spinal Cords in a Rat Model with Bone Cancer Pain

Huang,

Chen,

et al. 2024

JPR

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“…= 205–210°C; m.p lit . = 186–188°C 32 ; IR (KBr): v 3381, 2931, 1712, 1608, 1448, and 1157 cm −1 ; 1 H NMR (400 MHz, DMSO‐d 6 ) (ppm) = 8.04–8.13 (m, 1 H), 7.99 (d, J = 8.0 Hz, 1 H, ArH), 7.93 (d, J = 8.0 Hz, 1 H, ArH), 7.70–7.81 (m, 2 H, ArH), 7.57–7.63 (m, 1 H, ArH), 7.40–7.45 (m, 2 H, ArH), 7.05–7.17 (m, 2 H, ArH, OH), 6.36 (d, J = 8.0 Hz, 1 H, ArH), 6.29 (d, J = 4.0 Hz, 1 H, ArH), 6.02 (s, 1 H, OH), 1.79–2.16 (m, 4 H), 0.90 (s, 3 H, Me), 0.78 (s, 3 H, Me).…”

Section: Methodsmentioning

confidence: 99%

Sonocatalysis green synthesis of indeno[1,2‐b]indolone derivatives using CuFe₂O₄@CS‐SB nanocomposite as a reusable catalyst under mild conditions

Hassanpour,

Naeimi

2024

Applied Organom Chemis

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In this literature, the synthesis of indeno[1,2‐b]indolone from starting materials of ninhydrin, derivatives of aniline, and dimedone by using copper ferrite anchored to chitosan bearing Schiff base (CuFe2O4@CS‐SB) as a catalyst in water solvent under ultrasound irradiation was described. This catalyst was designed, fabricated, and characterized by the FT‐IR, 1H NMR, XRD, SEM, TGA, mapping scan, EDX, and BET techniques. This prepared acidic, effective heterogeneous catalyst catalyzed green synthesis of indeno‐indolone derivatives in a very short reaction times between 1 and 7 min with excellent yields between 95% and 99%. Also, the FT‐IR, 1H NMR, and melting point analyses are used to identify the synthesis of the indolones as organic products.

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Dysregulation of metalloproteins in ischemic heart disease patients with systolic dysfunction

Khan

Ullah

Hashmi

et al. 2023

International Journal of Biological Macromolecules

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Ionomic profiling of pericardial fluid in ischemic heart disease

Abstract: Metals are essential cofactors that play a crucial role in heart function at the cell and tissue level.

Cited by 3 publications

References 52 publications

Analysis of Ionomic Profiles of Spinal Cords in a Rat Model with Bone Cancer Pain

Analysis of Ionomic Profiles of Spinal Cords in a Rat Model with Bone Cancer Pain

Sonocatalysis green synthesis of indeno[1,2‐b]indolone derivatives using CuFe₂O₄@CS‐SB nanocomposite as a reusable catalyst under mild conditions

Dysregulation of metalloproteins in ischemic heart disease patients with systolic dysfunction

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Ionomic profiling of pericardial fluid in ischemic heart disease

Abstract: Metals are essential cofactors that play a crucial role in heart function at the cell and tissue level.

Cited by 3 publications

References 52 publications

Analysis of Ionomic Profiles of Spinal Cords in a Rat Model with Bone Cancer Pain

Analysis of Ionomic Profiles of Spinal Cords in a Rat Model with Bone Cancer Pain

Sonocatalysis green synthesis of indeno[1,2‐b]indolone derivatives using CuFe2O4@CS‐SB nanocomposite as a reusable catalyst under mild conditions

Dysregulation of metalloproteins in ischemic heart disease patients with systolic dysfunction

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Sonocatalysis green synthesis of indeno[1,2‐b]indolone derivatives using CuFe₂O₄@CS‐SB nanocomposite as a reusable catalyst under mild conditions