Ionizing radiation induces upregulation of cellular procoagulability and tissue factor expression in human peripheral blood mononuclear cells

Goldin-Lang, Petra; Niebergall, Florian; Antoniak, Silvio; Szotowski, Bjoern; Rosenthal, Peter; Pels, Klaus; Schultheiss, Heinz‐Peter; Rauch, Ursula

doi:10.1016/j.thromres.2007.01.008

Cited by 24 publications

(19 citation statements)

References 29 publications

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“…In addition, we showed IR to increase the procoagulant activity of SMCs in a time-and dose-dependent manner with an intensity comparable to rapamycin or paclitaxel treatment. This observation is in agreement with previous findings of our [1,21,23] and other groups [24], that pointed to irradiation to induce TF expression and activity. SMCs responded much faster to drug induction than to IR.…”

Section: Discussionsupporting

confidence: 94%

“…Ollivier et al showed rapamycin to inhibit LPSinduced TF expression and activity in monocytic cells [27]. These contrary findings may be based on activation of specific cell signaling pathways activated in monocytic cells in response to LPS compared to possibly different pathways in other cell lines such as SMCs without LPS stimulation or TNF-α induced EC [20,21,23]. In our study we used SMCs, shown to express higher TF mRNA level in response to rapamycin [22].…”

Section: Discussionmentioning

confidence: 81%

“…TF is constitutively expressed in various human tissues [18,19] as well as in several cell lines such as fibroblasts and SMCs [15,18]. Furthermore, it is inducible in various cells [18,20,21].…”

Section: Introductionmentioning

confidence: 99%

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Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, rapamycin and paclitaxel

Eisenreich¹,

Çelebi²,

Goldin-Lang³

et al. 2008

International Immunopharmacology

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 81%

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Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, rapamycin and paclitaxel

Eisenreich¹,

Çelebi²,

Goldin-Lang³

et al. 2008

International Immunopharmacology

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“…PBMNC-derived microparticles post-irradiation also initiated the plasma clotting faster than microparticles derived from controls. The radiation induced TF expression and increase in procoagulability of PBMNCs and cell-derived microparticles may represent a possible mechanism by which ionizing radiation enhances blood thrombogenicity (203). In a study performed with leukoreduced fresh-frozen plasma irradiated with 30 Gy of γ-rays, prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time, antithrombin III, protein C, protein S, vWF, ristocetin cofactor, plasminogen–α2-antiplasmin, the coagulation factors fibrinogen, FII, FV, FVII, VIII, F IX, FX, FXI, FXII, FXIII, and activated factor XII (FXIIa), D-dimer, fibrin monomer, thrombin–antithrombin complex, prothrombin fragment 1 + 2 (F1+2), plasmin–α2-antiplasmin complexes, and platelet factor 4 were determined, and PT, aPTT and FVIII activities were found to be decreased significantly, whereas activities of the coagulation factors FII, FV, FVII, FIX, FX, FXII were increased significantly post- irradiation (204).…”

Section: Acute Radiation Effectsmentioning

confidence: 99%

Biological effects of space radiation and development of effective countermeasures

Kennedy

2014

Life Sciences in Space Research

145

117

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As part of a program to assess the adverse biological effects expected from astronaut exposure to space radiation, numerous different biological effects relating to astronaut health have been evaluated. There has been major focus recently on the assessment of risks related to exposure to solar particle event (SPE) radiation. The effects related to various types of space radiation exposure that have been evaluated are: gene expression changes (primarily associated with programmed cell death and extracellular matrix (ECM) remodeling), oxidative stress, gastrointestinal tract bacterial translocation and immune system activation, peripheral hematopoietic cell counts, emesis, blood coagulation, skin, behavior/fatigue (including social exploration, submaximal exercise treadmill and spontaneous locomotor activity), heart functions, alterations in biological endpoints related to astronaut vision problems (lumbar puncture/intracranial pressure, ocular ultrasound and histopathology studies), and survival, as well as long-term effects such as cancer and cataract development. A number of different countermeasures have been identified that can potentially mitigate or prevent the adverse biological effects resulting from exposure to space radiation.

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“…Ionizing radiation is associated with an increased risk of thrombotic events, with delayed re-endothelialization, fibrin deposition and platelet recruitment as potential causes of postirradiation thrombosis (78). In our laboratory, we investigated a cohort of 217 patients from the Epinal accident (France), where patients with prostate adenocarcinoma were overexposed to radiation during radiotherapy (79).…”

Section: Microparticlesmentioning

confidence: 99%

Extracellular Vesicles and Vascular Injury: New Insights for Radiation Exposure

Flamant¹,

Tamarat²

2016

Radiation Research

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This article reviews our current knowledge about cell-derived extracellular vesicles (EVs), including microparticles and exosomes, and their emergence as mediators of a new important mechanism of cell-to-cell communication. Particular emphasis has been given to the increasing involvement of EVs in the field of radiation-induced vascular injury. Although EVs have been considered for a long time as cell “dust”, they in fact precisely reflect the physiological state of the cells. The role of microparticles and exosomes in mediating vascular dysfunction suggests that they may represent novel pathways in short- or long-distance paracrine intercellular signaling in vascular environment. In this article, the mechanisms involved in the biogenesis of microparticles and exosomes, their composition and participation in the pathogenesis of vascular dysfunction are discussed. Furthermore, this article highlights the concept of EVs as potent vectors of biological information and protagonists of an intercellular communication network. Special emphasis is made on EV-mediated microRNA transfer and on the principal consequences of such signal exchange on vascular injury and radiation-induced non-targeted effect. The recent progress in elucidating the biology of EVs has provided new insights for the field of radiation, advancing their use as diagnostic biomarkers or in therapeutic interventions.

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Ionizing radiation induces upregulation of cellular procoagulability and tissue factor expression in human peripheral blood mononuclear cells

Cited by 24 publications

References 29 publications

Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, rapamycin and paclitaxel

Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, rapamycin and paclitaxel

Biological effects of space radiation and development of effective countermeasures

Extracellular Vesicles and Vascular Injury: New Insights for Radiation Exposure

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