Ionizing Radiation-Induced Brain Cell Aging and the Potential Underlying Molecular Mechanisms

Wang, Qinqi; Yin, Gang; Huang, Jiangrong; Xi, Shi-Jun; Qian, Feng; Lee, Rui-Xue; Peng, Xiaochun; Tang, Feng Ru

doi:10.3390/cells10123570

Cited by 20 publications

(18 citation statements)

References 208 publications

(224 reference statements)

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“…Brain aging is associated with chronic inflammation of the nervous system. Senile chronic injury breaks the homeostasis of the microenvironment where neurons live, leading to the imbalance of inflammatory cytokines and the related inhibitors, causing the degeneration, necrosis, and apoptosis of neurons [ 54 ]. Hippocampus CA1 is the most sensitive to external pathological factors and it is also the place where pathological changes first occur.…”

Section: Discussionmentioning

confidence: 99%

Enhanced UV-B Radiation Induced the Proanthocyanidins Accumulation in Red Rice Grain of Traditional Rice Cultivars and Increased Antioxidant Capacity in Aging Mice

Sheng

et al. 2023

IJMS

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Proanthocyanidins are major UV-absorbing compounds. To clarify the effect of enhanced UV-B radiation on the proanthocyanidin synthesis and antioxidant capacity of traditional rice varieties in Yuanyang terraced fields, we studied the effects of enhanced UV-B radiation (0, 2.5, 5.0, 7.5 kJ·m−2·d−1) on the rice grain morphology, proanthocyanidins content, and synthesis. The effects of UV-B radiation on the antioxidant capacity of rice were evaluated by feeding aging model mice. The results showed that UV-B radiation significantly affected the grain morphology of red rice and increased the compactness of starch grains in the starch storage cells of central endosperm. The content of proanthocyanidin B2 and C1 in the grains was significantly increased by 2.5 and 5.0 kJ·m−2·d−1 UV-B radiation. The activity of leucoanthocyanidin reductase was higher in rice treated by 5.0 kJ·m−2·d−1 than other treatments. The number of neurons in the hippocampus CA1 of mice brain fed red rice increased. After 5.0 kJ·m−2·d−1 treatment, red rice has the best antioxidant effect on aging model mice. UV-B radiation induces the synthesis of rice proanthocyanidins B2 and C1, and the antioxidant capacity of rice is related to the content of proanthocyanidins.

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Section: Discussionmentioning

confidence: 99%

Enhanced UV-B Radiation Induced the Proanthocyanidins Accumulation in Red Rice Grain of Traditional Rice Cultivars and Increased Antioxidant Capacity in Aging Mice

Sheng

et al. 2023

IJMS

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“…Moreover, environmental factors, including radiation, can accelerate the onset and progression of diabetes with more serious side effects [ 28 ]. Similar to diabetes, radiation causes damage to blood vessels and tissues and affects aging [ 29 ]. Extensive clinical and experimental evidence suggests that endothelial dysfunction occurs in T2DM and prediabetes patients [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Low-Dose Radiation Affects Cardiovascular Disease Risk in Human Aortic Endothelial Cells by Altering Gene Expression under Normal and Diabetic Conditions

Lee

Jeong

Park

et al. 2022

IJMS

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High doses of ionizing radiation can cause cardiovascular diseases (CVDs); however, the effects of <100 mGy radiation on CVD remain underreported. Endothelial cells (ECs) play major roles in cardiovascular health and disease, and their function is reduced by stimuli such as chronic disease, metabolic disorders, and smoking. However, whether exposure to low-dose radiation results in the disruption of similar molecular mechanisms in ECs under diabetic and non-diabetic states remains largely unknown; we aimed to address this gap in knowledge through the molecular and functional characterization of primary human aortic endothelial cells (HAECs) derived from patients with type 2 diabetes (T2D-HAECs) and normal HAECs in response to low-dose radiation. To address these limitations, we performed RNA sequencing on HAECs and T2D-HAECs following exposure to 100 mGy of ionizing radiation and examined the transcriptome changes associated with the low-dose radiation. Compared with that in the non-irradiation group, low-dose irradiation induced 243 differentially expressed genes (DEGs) (133 down-regulated and 110 up-regulated) in HAECs and 378 DEGs (195 down-regulated and 183 up-regulated) in T2D-HAECs. We also discovered a significant association between the DEGs and the interferon (IFN)-I signaling pathway, which is associated with CVD by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, protein–protein network analysis, and module analysis. Our findings demonstrate the potential impact of low-dose radiation on EC functions that are related to the risk of CVD.

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“…Based on the molecular mechanism of radiationinduced brain damage seen in these studies [133][134][135][136][137], the neuroprotective effect of Lycium barbarum in the ischemic stroke model and other diseases may also apply to radiationinduce brain damage (Fig. 3).…”

Section: Radioprotective Effects and Molecular Mechanisms Of Lycium B...mentioning

confidence: 98%

Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure

Huang¹,

Zhang²,

Chen³

et al. 2023

Front. Biosci. (Landmark Ed)

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Ischemic stroke and cranial radiotherapy may induce brain inflammatory response, oxidative stress, apoptosis and neuronal loss, and impairment of neurogenesis. Lycium barbarum has anti-oxidation, anti-inflammatory, anti-tumor and anti-aging properties, may produce both neuroprotective and radioprotective effects. In this narrative review paper, we described the neuroprotective effect of Lycium barbarum in different animal models of experimental ischemic stroke and limited studies in irradiated animal models. Relevant molecular mechanisms are also summarized. It has been shown that in experimental ischemic stroke models, Lycium barbarum produces neuroprotective effects by modulating neuroinflammatory factors such as cytokines and chemokines, reactive oxygen species, and neurotransmitter and receptor systems. In irradiation animal models, Lycium barbarum prevents radiation-induced loss of hippocampal interneurons. Given its minimal side-effects, these preclinical studies suggest that Lycium barbarum may be a promising radio-neuro-protective drug that can be used as an adjunct treatment to radiotherapy for brain tumor and in the treatment of ischemic stroke. At molecular levels, Lycium barbarum may regulate PI3K/Akt/GSK-3β, PI3K/Akt/mTOR, PKCε/Nrf2/HO-1, keap1-Nrf2/HO-1, and NR2A and NR2B receptor-related signal transduction pathways to produce neuroprotective effects.

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Ionizing Radiation-Induced Brain Cell Aging and the Potential Underlying Molecular Mechanisms

Cited by 20 publications

References 208 publications

Enhanced UV-B Radiation Induced the Proanthocyanidins Accumulation in Red Rice Grain of Traditional Rice Cultivars and Increased Antioxidant Capacity in Aging Mice

Enhanced UV-B Radiation Induced the Proanthocyanidins Accumulation in Red Rice Grain of Traditional Rice Cultivars and Increased Antioxidant Capacity in Aging Mice

Low-Dose Radiation Affects Cardiovascular Disease Risk in Human Aortic Endothelial Cells by Altering Gene Expression under Normal and Diabetic Conditions

Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure

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