Ionized magnesium level in whole blood of healthy Japanese children

Hoshino, Kenji; Ogawa, Kiyoshi; Kitazawa, Reiko; Nakamura, Yoshihiro; Uehara, Ritei

doi:10.1111/j.1442-200x.1998.tb01894.x

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…However, only a few reports have measured iMg 2+ levels in children using the NOVA CRT8. One by Hoshiono et al involved 160 healthy Japanese children and found that the mean iMg 2+ level was 0.53 ± 0.03 (range: 0.45–0.63) mmol/L [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Risk of low serum levels of ionized magnesium in children with febrile seizure

et al. 2018

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BackgroundSuboptimal intake of magnesium become prevalent due to the modern diet of processed food low in magnesium. Magnesium may modulate seizure activity by antagonizing excitatory calcium influx through the N-methyl-D-aspartate receptor. Although hyponatremia has been reported to be common in febrile seizures, the most common form of seizure, little is known about the status of serum ionized magnesium. We therefore investigated the status of serum ionized magnesium (iMg2+) in children with febrile seizures and compared with controls.MethodsWe included all patients from 1 to 6 years old who had presented with febrile seizure to the pediatric emergency department at the Korea University Guro Hospital from July 2016 to February 2017. The control group comprised patients admitted to the hospital with febrile respiratory tract infections, but with no history of febrile seizure. Clinical data, blood tests, and electroencephalogram (EEG) results were reviewed using the patients’ medical records.ResultsA total of 133 patients with febrile seizure and 141 control patients were analyzed in the present study. As a result, hypomagnesemia (< 0.50 mmol/L) was more common in patients with febrile seizure than in controls (42.9% vs. 6.9%, p < 0.001) and it was an independent risk factor for febrile seizure (OR, odds ratio = 22.12, 95% CI = 9.23–53.02, P < 0.001). A receiver operating curve analysis revealed that serum iMg2+ levels < 0.51 mmol/L predicted the presence of febrile seizures with a sensitivity of 45.1% and a specificity of 92.6% (AUC, area under the curve = 0.731, 95% confidence interval = 0.671–0.791). When the patients with febrile seizure were divided in terms of a serum iMg2+ concentration of 0.51 mmol/L, there was no difference in clinical features.ConclusionsHypomagnesemia was more common and serum iMg2+ level was lower in patients with febrile seizures than in controls. However, further evidence is needed for the causal relationship between low magnesium and febrile convulsions.

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Section: Discussionmentioning

confidence: 99%

Risk of low serum levels of ionized magnesium in children with febrile seizure

et al. 2018

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“…In a study of healthy volunteers, the mean whole blood ionized Mg concentration was 0·52 mmol/l with a range of 0·44 to 0·59 mmol/l and an ionized Mg/total serum Mg ratio of 0·60 and a range of 0·50–0·69 ( 78 ) . A positive correlation between ionized and serum total Mg was observed in 160 healthy children and the ratio was 58·3 ± 4·1 % ( 79 ) . There appears to be no demonstrable advantage to measuring ionized Mg as opposed to total Mg for evaluating Mg status.…”

Section: Tissuesmentioning

confidence: 99%

Update on the assessment of magnesium status

2008

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Magnesium (Mg) is the fourth most abundant mineral in the body and the most abundant intracellular divalent cation, with essential roles in many physiological functions. Consequently, the assessment of Mg status is important for the study of diseases associated with chronic deficiency. In spite of intense research activities there is still no simple, rapid, and accurate laboratory test to determine total body Mg status in humans. However, serum Mg ,0·75 mmol/l is a useful measurement for severe deficiency, and for values between 0·75 and 0·85 mmol/l a loading test can identify deficient subjects. The loading test seems to be the gold standard for Mg status, but is unsuitable in patients with disturbed kidney and intestinal functions when administered orally. There is also a need to reach a consensus on a standardized protocol in order to compare results obtained in different clinical units. Other cellular Mg measurements, such as total or ionized Mg, frequently disagree and more research and systematic evaluations are needed. Muscle Mg appears to be a good marker, but biopsies limit its usefulness, as is the case with bone Mg, the most important but heterogeneous Mg compartment. The development of new and non invasive techniques such as nuclear magnetic resonance (NMR) may provide valuable tools for routinely analysing ionized Mg in tissues. With the development of molecular genetics techniques, the recent discovery of Transient Receptor Potential Melastatin channels offers new possibilities for the sensitive and rapid evaluation of Mg status in humans.Loading test: Serum: Erythrocyte: Lymphocytes: Muscle: Bone: Ionized Mg Magnesium (Mg) is the fourth most abundant mineral in the body, and the most abundant intracellular divalent cation, and is essential for a diverse range of physiological functions. Mg deficiency, either from inadequate intake, excess excretion or altered homeostasis, is often suspected to be associated with the initiation of many symptoms and diseases (1) . In spite of its multiple and ubiquitous roles, Mg status can be assessed in severe deficiency and a large number of studies have investigated various markers during nutritionally induced or pathological mild and chronic deficiency. A review published in 1991 stated that the assessment of Mg status was difficult as there was no simple, rapid and accurate test to indicate total body Mg status (2) . More recently, another review indicated that whilst functional and/or biological markers are available for many nutrients, there is still a need for indicators to specifically diagnose Mg deficiency (3) . Another difficulty associated with Mg is related to its metabolism. It is known that the equilibrium and exchange of Mg between body compartments and tissue pools occurs slowly, so determining Mg concentration in one tissue may not provide information about Mg status in another. This review provides the most up-to-date information on the assessment of Mg status. MetabolismThe metabolism of Mg and its body distribution have been investigated in an...

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“…Our observation that serum Mg showed a significant correlation with age is consistent with previous reports of a relationship between age and serum Mg in healthy individuals. 23,24 Mg supplementation can increase bone density and arrest bone loss in osteoporotic patients 25 and its supplementation in children with ALL and hypomagnesemia is associated with a variable rise in serum Mg and a rise in osteocalcin levels. 6 It is possible that this variable response in serum Mg is age dependent and needs further exploration.…”

Section: Discussionmentioning

confidence: 99%