Abstract:Drugs that increase the concentration of catechol and indolic amines in brain may relieve depression, while those that lower their concentration may cause it.
“…The study selection process, from initial search to final selection, is presented in Figure 1 . Table 1 and Supplementary Table 10 list the articles that were included in our meta-analyses 14 , 15 , 27 – 32 , 45 – 94 and provide information on their characteristics. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…We searched PubMed, Web of Science, and Embase (from their commencement to 22 December 2017) for eligible papers using the following terms: (Magnesium OR Mg*) AND (depression OR depress* OR affect* OR mood OR mania OR bipolar). The reference lists of identified articles were scrutinised, as were the references that were made to the two seminal papers on the topic 14 , 15 (to which, at the date of our latest search, 65 and 5 references were made respectively).…”
BackgroundMagnesium (Mg2+) has received considerable attention with regards to its potential role in the pathophysiology of the mood disorders, but the available evidence seems inconclusive.AimsTo review and quantitatively summarise the human literature on Mg2+ intake and Mg2+ blood levels in the mood disorders and the effects of Mg2+ supplements on mood.MethodSystematic review and meta-analyses.ResultsAdherence to a Mg2+-rich diet was negatively associated with depression in cross-sectional (odds ratio = 0.66) but not in prospective studies. Mg2+ levels in bodily fluids were on average higher in patients with a mood disorder (Hedge's g = 0.19), but only in patients treated with antidepressants and/or mood stabilisers. There was no evident association between Mg2+ levels and symptom severity. Mg2+ supplementation was associated with a decline in depressive symptoms in uncontrolled (g = −1.60) but not in placebo-controlled trials (g = −0.21).ConclusionOur results provide little evidence for the involvement of Mg2+ in the mood disorders.Declaration of interestNone.
“…The study selection process, from initial search to final selection, is presented in Figure 1 . Table 1 and Supplementary Table 10 list the articles that were included in our meta-analyses 14 , 15 , 27 – 32 , 45 – 94 and provide information on their characteristics. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…We searched PubMed, Web of Science, and Embase (from their commencement to 22 December 2017) for eligible papers using the following terms: (Magnesium OR Mg*) AND (depression OR depress* OR affect* OR mood OR mania OR bipolar). The reference lists of identified articles were scrutinised, as were the references that were made to the two seminal papers on the topic 14 , 15 (to which, at the date of our latest search, 65 and 5 references were made respectively).…”
BackgroundMagnesium (Mg2+) has received considerable attention with regards to its potential role in the pathophysiology of the mood disorders, but the available evidence seems inconclusive.AimsTo review and quantitatively summarise the human literature on Mg2+ intake and Mg2+ blood levels in the mood disorders and the effects of Mg2+ supplements on mood.MethodSystematic review and meta-analyses.ResultsAdherence to a Mg2+-rich diet was negatively associated with depression in cross-sectional (odds ratio = 0.66) but not in prospective studies. Mg2+ levels in bodily fluids were on average higher in patients with a mood disorder (Hedge's g = 0.19), but only in patients treated with antidepressants and/or mood stabilisers. There was no evident association between Mg2+ levels and symptom severity. Mg2+ supplementation was associated with a decline in depressive symptoms in uncontrolled (g = −1.60) but not in placebo-controlled trials (g = −0.21).ConclusionOur results provide little evidence for the involvement of Mg2+ in the mood disorders.Declaration of interestNone.
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