The equipment, working principles, performance and disturbing effects of re-entrant (or 4π) pressurized ionization-chamber measuring systems for activity determinations of photon-emitting radionuclide sources are described. Important features of these systems are the measuring geometry—generally reproducible and repeatable, ‘stable’ measurement conditions and instrument response, in particular linearity with varying activity. Properties of the current-measuring electronics are also considered. Basic equations for instrument calibrations and related uncertainties are given. A few applications, particularly half-life measurements, are represented. Finally, the bibliography of publications during the past ten years is reviewed.