Ionising radiation and leukaemia potential risks: review based on the workshop held during the 10th Symposium on Molecular Biology of Hematopoiesis and Treatment of Leukemia and Lymphomas at Hamburg, Germany on 5 July 1997

Fe, Alexander; Mw, Greaves

doi:10.1038/sj.leu.2401120

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…No large study documented an increased incidence of ALL as a result of this accident. 9,[27][28][29] Our data also cannot be explained by increased ionizing radiation in 1986 since there is no clue why children aged 1 to 4 years should be affected even 13 years following the accident whilst others would remain unaffected.…”

Section: Leukemiamentioning

confidence: 70%

Acute lymphoblastic leukemia incidence during socioeconomic transition: selective increase in children from 1 to 4 years

Hrušák¹,

Trka²,

Zuna³

et al. 2002

Leukemia

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Pre-school acute lymphoblastic leukemia (ALL) peak is consistent in developed but not in developing countries and its magnitude apparently correlates with the socioeconomic status. A population-based study describing ALL incidence during socioeconomic transition has been lacking. Central European postcommunist countries (with very low foreign migration and centralized statistics) offer reliable data for the period before and during major socioeconomic changes. Population-based data on Czech ALL patients younger than 18 years were taken from two independent Czech national registries partially overlapping in time (1980-1998, n = 1236 and 1991-1999, n = 570). During the 1980s and 1990s, ALL incidence among children 1-4 years increased 1.5 times (P = 0.01). This increase was more prominent in females than in males (slopes 0.13 and 0.09, P values 0.03 and Ͼ0.05, respectively). No significant change was observed in other age groups (0, 5-9, 10-14, 15-17 years or all others combined). We discuss possible underlying socioeconomic factors including infant care and breast-feeding, hygiene, birth order, industry and pollution. Moreover, we try to pinpoint the immunophenotypic/molecular-genetic subsets of ALL that might be socioeconomically affected. Selective increase of ALL in children 1-4 years old provides epidemiological evidence that etiology and/or trigger mechanisms are different for a considerable proportion of these children and that these mechanisms are exogenous. Leukemia (2002) 16, 720-725.

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Section: Leukemiamentioning

confidence: 70%

Acute lymphoblastic leukemia incidence during socioeconomic transition: selective increase in children from 1 to 4 years

Hrušák¹,

Trka²,

Zuna³

et al. 2002

Leukemia

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“…Selection of this subpopulation of hematopoietic stem cells provides the opportunity to enrich for the BFU-E colony forming cells. 1 Moreover, the CD34 + /CD36 − sorted bone marrow cells can selectively differentiate in the in vitro suspension culture assay along the erythroid lineage in the presence of erythropoietin and mast cell growth factor. 1 By using these assays we demonstrated a strong impairment in the proliferative response of CD34 + /CD36 − sorted bone marrow cells of myelodysplasia patients.…”

Section: Responsementioning

confidence: 99%

“…1 Moreover, the CD34 + /CD36 − sorted bone marrow cells can selectively differentiate in the in vitro suspension culture assay along the erythroid lineage in the presence of erythropoietin and mast cell growth factor. 1 By using these assays we demonstrated a strong impairment in the proliferative response of CD34 + /CD36 − sorted bone marrow cells of myelodysplasia patients. 2,3 In contrast, the sorted CD34 + /CD36 − bone marrow cells differentiated in the in vitro suspension culture assay to a certain degree along the erythroid lineage.…”

Section: Responsementioning

confidence: 99%

Inaccuracy and vested interests-two threats to etiologic research

Hoffmann

Straif

1999

Leukemia

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References1 Brada SJL, de Wolf JThW, Hendriks DW, Smit JW, Vellenga E.CD34 + /CD36 − cells from myelodysplasia patients have a limited ResponseOne of the main characteristics of myelodysplasia is anemia, despite the fact that a normal or increased number of normoblasts are observed in the bone marrow. To study whether this discrepancy might be in part due to a defect in the proliferation and differentiation of erythroid progenitors, an in vitro culture system was used with CD34 + /CD36 − sorted bone marrow cells of myelodysplasia patients. Selection of this subpopulation of hematopoietic stem cells provides the opportunity to enrich for the BFU-E colony forming cells. 1 Moreover, the CD34 + /CD36 − sorted bone marrow cells can selectively differentiate in the in vitro suspension culture assay along the erythroid lineage in the presence of erythropoietin and mast cell growth factor. 1 By using these assays we demonstrated a strong impairment in the proliferative response of CD34 + /CD36 − sorted bone marrow cells of myelodysplasia patients. 2,3 In contrast, the sorted CD34 + /CD36 − bone marrow cells differentiated in the in vitro suspension culture assay to a certain degree along the erythroid lineage. 3 These results demonstrate that by using highly selective cell populations, important information can be obtained with regard to the proliferative and differentiative capacity of erythroid progenitors of myelodysplasia patients. However, these data were not of predictive value for the in vivo erythroid kinetic data measured with ferrokinetic studies. 4 COMMENTS ON PUBLISHED PAPERS Inaccuracy and vested interests -two threats to etiologic research TO THE EDITORAlexander and Greaves in their report 1 focus on two main points. The first is the hypothesis of an infectious cause for childhood leukemia. While this hypothesis has been put forward in several previous publications of these authors, it was not a major issue on the Workshop. In particular, none of the

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