Ionically Functionalized Polyacetylenes

Robinson, Stephen G.; Lonergan, Mark C.

doi:10.1002/9783527655700.ch3

Cited by 1 publication

(2 citation statements)

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“…Because the nearinfrared (NIR) light can realize the deep-tissue penetration with a quite low level of the total extinction coefficient and is minimal absorbed by biological tissues, 7−11 various organic and inorganic phototherapeutic agents with optical absorbance in the NIR region have exhibited inspiring photothermal therapeutic efficacy in preclinical experiments. 6,12−17 As an important kind of macromolecules, conjugated polymers, especially in the doping of polyacetylene, 18,19 were successfully prepared and widely applied in a number of fields, 20 such as solar cells, bioimaging, and biomedicine. 21 Conjugated polymers are polymers with conjugated bond structures and repeating chemical units with delocalized π-electron systems.…”

Section: Introductionmentioning

confidence: 99%

“…As an important kind of macromolecules, conjugated polymers, especially in the doping of polyacetylene, , were successfully prepared and widely applied in a number of fields, such as solar cells, bioimaging, and biomedicine . Conjugated polymers are polymers with conjugated bond structures and repeating chemical units with delocalized π-electron systems.…”

Section: Introductionmentioning

confidence: 99%

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Conjugated-Polymer-Based Nanomaterials for Photothermal Therapy

Wang

Meng

Song

et al. 2020

ACS Appl. Polym. Mater.

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In the past few decades, the development of excellent materials for the treatment of disease via noninvasive photothermal therapy has received increasing attention. Among a number of kinds of nanomaterials, conjugated-polymer-based nanomaterials, which possess intense absorbance in the near-infrared region, could employed as useful photothermal agents for various disease treatments, such as cancer, bacterial infection therapy, and neurodegenerative disease. Moreover, conjugated-polymer-based nanomaterials can be easily combined with other imaging agents and drugs to construct multifunctional nanomaterials for cascading stimuli-responsiveness with precise medical treatment and enhanced therapy efficacy. Here, we mainly put attention on the recent advances of conjugated-polymer-based nanoparticles for photothermal therapy. First, we briefly summarized the mechanism of photothermal conversion of conjugated polymers and the relevant modified methods to improve their photothermal conversion efficiency. Second, we discussed the application of conjugated polymers in photothermal therapy as well as the strategies for developing conjugated-polymer-based nanomaterials with a targeted ability and an enhanced accumulation effect on the tumor region for cancer therapy. Moreover, further challenges and perspectives were also discussed for designing efficient conjugated-polymer-based nanosystems for photothermally assisted therapies.

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