Ionically Complexed Nanoparticles for Heparin Oral Delivery

Abstract

Ionically complexed nanoparticles were prepared from an anionic polysaccharide drug, heparin, entrapped by a positively charged chitosan polysaccharide. In this study, the encapsulation of heparin was studied to optimize properties needed for its oral drug delivery. Chitosan, used in a variety of biomedical applications, was selected as a cationic polymer for heparin encapsulation. These particles were prepared with a slightly positive charge and an appropriate size for oral drug delivery. The release profiles of these ionically complexed nanoparticles were improved by using FDA approved stabilizers, such as pluronic non-ionic surfactant and polyvinyl alcohol. These results obtained in vitro suggest that these stabilized, ionically complexed nanoparticles may be well-suited for the oral drug delivery of heparin into the gastrointestinal tract.

Design of Chitosan-Coated, Quercetin-Loaded PLGA Nanoparticles for Enhanced PSMA-Specific Activity on LnCap Prostate Cancer Cells

“…Slightly more positive (+9 mV) chitosan nanoparticles were also prepared by [ 79 ] and investigated for their drug release of plasmid DNA. The study showed complete release in 24 h. More recently, Subramaniam and co-workers [ 80 ] aimed to fabricate chitosan nanoparticles with a charge between +1 and +10 mV for increased cellular penetration. The prepared nanoparticles were +19 mV, and it achieved 70% release of its payload after 4 h at pH 7.2.…”