Ionic mechanisms of electrical remodeling in human atrial fibrillation

Abstract

AF in humans leads to important changes in atrial potassium and calcium currents that likely contribute to the decrease in APD and APD rate adaptation. These changes contribute to electrical remodeling in AF and are therefore important factors for the perpetuation of the arrhythmia.

Dynamics of human atrial cell models: Restitution, memory, and intracellular calcium dynamics in single cells

“…The reduction in rate adaptation shown by the models is in agreement with a number of experimental studies that show little rate adaptation in MAP recordings shortly after cardioversion of chronic AF (Franz et al, 1997;Kamalvand et al, 1999;Manios et al, 2000;Osaka et al, 2000) and in isolated myocytes (Bosch et al, 1999;Van Wagoner et al, 1999;Workman et al, 2001) and tissues (Boutjdir et al, 1986) obtained from right atrial appendage tissue of patients with chronic AF. In some cases, more significant rate adaptation can be observed at the shortest CLs (Kim et al, 2002;Dobrev and Ravens, 2003).…”

“…In some cases, more significant rate adaptation can be observed at the shortest CLs (Kim et al, 2002;Dobrev and Ravens, 2003). Similar alterations to those given by Courtemanche et al (1999) have been observed in other experiments as well (Dobrev and Ravens, 2003), including substantial reductions in I Ca,L (Bosch et al, 1999;Van Wagoner et al, 1999;Skasa et al, 2001;Workman et al, 2001) and I to (Van Wagoner et al, 1997;Bosch et al, 1999;Brandt et al, 2000;Grammer et al, 2000;Workman et al, 2001). The reduction in I Kur proposed by Courtemanche et al (1999) has been found in some studies (Van Wagoner et al, 1997;Brandt et al, 2000) but not in others (Grammer et al, 2000;Workman et al, 2001).…”

Validation of SYNTAX and clinical SYNTAX scores in predicting atrial fibrillation following on-pump coronary artery bypass grafting

“…These alterations include shortening of the atrial wavelength or decreasing the atrial refractory period. [32] Mendes et al [33] reported that angiographic evidence of right coronary artery stenosis was a predictor of PoAF. Gecmen et al [34] also found that higher SYNTAX scores were related to more frequent PoAF in patients undergoing isolated on-pump CABG.…”

Differences in atrial fibrillation properties under vagal nerve stimulation versus atrial tachycardia remodeling

“…AF increases expression levels of mRNA of Kir2.1 (channel subunit of K ir ), consistent with larger I K1 76, 84 . Moreover, an increase in I K1 has been observed in either human 81,85 or animal AF studies 86 , contributing to a faster repolarization, thus reducing further the APD 75 .…”