Ionic liquids toxicity on fresh water microalgae, Scenedesmus quadricauda, Chlorella vulgaris &amp; Botryococcus braunii; selection criterion for use in a two-phase partitioning bioreactor (TPPBR)

Quraishi, Khurrum Shehzad; Bustam, Mohamad Azmi; Krishnan, S.; Aminuddin, Noor Fathanah; Azeezah, Noraisyah; Ghani, Noraini Abd; Uemura, Yoshimitsu; Lévêque, Jean Marc

doi:10.1016/j.chemosphere.2017.06.037

Cited by 30 publications

(8 citation statements)

References 36 publications

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“…Environmental toxicity assessment protocols for the selection of environmentally safe compounds are well-established for the microalgae Chlorella vulgaris and Scenedesmus obliquus [86][87][88][89] and for the ciliated protozoan T. pyriformis. 46,90 The compounds 3a, 3e, 6a, 6c, 6d and 6f were not toxic to the algae Chlorella vulgaris BR017 and to the protozoan T. pyriformis, indicating that they are relatively safe for the environment.…”

Section: Discussionmentioning

confidence: 99%

Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Targanski

Sousa

Pádua

et al. 2020

Pest Management Science

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BACKGROUND: The expansion of Aedes aegypti (Diptera: Culicidae) population has increased the number of cases of arboviruses, in part due to the inefficiency and toxicity of the chemical control methods available to control this vector. We synthesized 19 chalcone derivatives and examined their activity against Ae. aegypti larvae in order to select larvicidal compounds that are non-toxic to other organisms. RESULTS: Seven chalcone derivatives (3a, 3e, 3f, 6a, 6c, 6d, and 6f) had lethal concentrations of substituted chalcones capable of killing 50% (LC 50) values lower than 100 mg mL −1 at 24 h post-treatment, which is the dose that the World Health Organization recommends for the selection of promising larvicides. The type of substituent added to (E)-1,3-diphenylprop-2-en-1-one (3a) markedly affected the larvicidal activity. Addition of chlorine, bromine and methoxy groups to the aromatic rings reduced the larvicidal activity, while replacement of the Bring (phenyl) by a furan ring significantly increased the larvicidal activity. The furan-chalcone (E)-3-(4-bromophenyl)-1-(furan-2-yl)prop-2-en-1-one (6c) killed Ae. aegypti larvae (LC 50 = 6.66 mg mL −1 ; LC 90 = 9.97 mg mL −1) more effectively than the non-substituted chalcone (3a) (LC 50 = 14.43 mg mL −1 ; LC 90 = 20.96 mg mL −1), and was not toxic to the insect Galleria mellonella, to the protozoan Tetrahymena pyriformis, and to the algae Chorella vulgaris. CONCLUSIONS: The substitution pattern of chalcones influenced their larvicidal activity. In the set of compounds tested, (E)-3-(4-bromophenyl)-1-(furan-2-yl)prop-2-en-1-one (6c) was the most effective larvicide against Ae. aegypti, with no clear signs of toxicity to other animal models. Its mechanism of action and effectiveness under field conditions remain to be determined.

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Section: Discussionmentioning

confidence: 99%

Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Targanski

Sousa

Pádua

et al. 2020

Pest Management Science

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“…Solubility of ionic liquid for cellulose and polysaccharide analogues in the cell wall may result in peak-type change of 1760~980 cm −1 . The depolymerization and allosteric structure of protein may be the reason for the large change of the peak shape of 1100-900 cm −1 [27].…”

Section: Analytical Methodmentioning

confidence: 99%

Repeated Utilization of Ionic Liquid to Extract Lipid from Algal Biomass

Zhou

Wang

Alam

et al. 2019

International Journal of Polymer Science

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In this work, different kinds of ionic liquids and reaction conditions for the extraction of lipid from microalgae biomass were optimized and repeated use of ionic liquids for microalgal lipid extraction was evaluated. Morphological changes of microalgae cells were compared in terms of pre- and post-treatment to understand the mechanisms of ionic liquid treatment. Ionic liquid [BMIM][MeSO4] showed the best lipid extraction efficiency at 70°C and with reaction time of 2 hours. The ratios (ILs : methanol) of 1 : 7 and 1 : 3 were the optimum ratios to complete the extraction of the lipids from microalgae. The initial 50% volume fraction of [BMIM][MeSO4] was 16.04% of dry weight, which showed the highest five average extraction rates. The loss of ionic liquid in the reaction system and the increase in water content of ionic liquids were considered as the main reasons for the decrease in the extraction rate. It is suggested that the potential of lipid extraction in this IL-methanol co-solvent system is promising due to the high efficiency, low cost, safety, environmental protection, and other characteristics.

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“…However, many studies have shown that ILs may be released into aquatic environments via effluent discharges and accidental spills and cause damage to aquatic organisms . For example, IL toxicity has been evaluated in microalgae, fish, and in Daphnia magna . In addition, several previous studies also showed that ILs are cytotoxic to many classes of cells, such as the human HeLa cell line, and PC12 cells .…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity, genotoxicity, oxidative stress, and apoptosis in HepG2 cells induced by the imidazole ionic liquid 1‐dodecyl‐3‐methylimidazolium chloride

Wang

Wan

Huo

et al. 2020

Environmental Toxicology

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This study purposes to assess the cytotoxicity of 1-dodecyl-3-methylimidazolium chloride ([C 12 min]Cl) in human hepatocellular carcinoma (HepG2) cells. To this end, HepG2 cells were exposed to a range concentration of [C 12 min]Cl and evaluated cell viability, genotoxicity, oxidative stress, apoptosis, cell cycle, and apoptosis-related gene expression to determine cytotoxicity. The outcomes showed that [C 12 min]Cl curbed HepG2 cell growth and reduced cell viability in a concentration-and time-dependent manner.Moreover, our assay results also revealed that exposure to [C 12 min]Cl prompted DNA damage and apoptosis, reduced SOD and GSH content, enhanced MDA level, and changed the cell cycle of HepG2 cells. In addition, [C 12 min] Cl caused alters in the expression levels of p53, Bax, and Bcl-2, indicating that p53 and Bcl-2 family may be involved in the cytotoxicity and apoptosis of HepG2 cells induced by [C 12 min]C1. In summary, these results indicate that [C 12 min]Cl exerts genotoxicity, physiological toxicity and prompts apoptosis in HepG2 cells, and is not an alleged green solvent. K E Y W O R D S apoptosis, cytotoxicity, genotoxicity, ionic liquids, oxidative stress 1 | INTRODUCTION Ionic liquids (ILs) are low melting organic salts at room temperature and are considered a green substitute for industrial volatile organic compounds. 1-3 They are composed of various cations and anions, for example, imidazolium, pyridinium, bromide (Br − ), and chloride (Cl − ). 4 Last several years, ILs have drawn wide attention owing to their unique excellent physical and chemical properties, such as low vapor pressure and nonvolatility, 5,6 good thermal and chemical stability, 7,8and relatively high viscosity. 9 These ILs as environmentally friendly chemicals are famous mainly because their vapor pressure is negligible compared to many inorganic and organic materials. 5,10 Due to their unique properties, ILs are currently being used in a diverse range of applications, including ecology, 11,12 chemical engineering, 13 the medical field, 14 food industry, 15 textiles, 16 and electrochemistry. 17 However, many studies have shown that ILs may be released into aquatic environments via effluent discharges and accidental spills and cause damage to aquatic organisms. 18,19 For example, IL toxicity has been evaluated in microalgae, 20 fish, 21,22 and in Daphnia magna. 23 In addition, several previous studies also showed that ILs are cytotoxic to many classes of cells, such as the human HeLa cell line, 24 and PC12 cells. 25 In contrast, limited information is available on the toxic mechanism of ILs, which is important in risk evaluation.The human hepatocellular carcinoma (HepG2) cell line was derived from a hepatoblastoma at first and retains the structural and functional polarity that hepatocytes exhibit in vivo. 26 It plays a key role in the activation/detoxification of genotoxic procarcinogens and reflects the metabolism of such compounds in vivo better than experimental models with metabolically incompetent cells and exog...

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Ionic liquids toxicity on fresh water microalgae, Scenedesmus quadricauda, Chlorella vulgaris & Botryococcus braunii; selection criterion for use in a two-phase partitioning bioreactor (TPPBR)

Cited by 30 publications

References 36 publications

Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Repeated Utilization of Ionic Liquid to Extract Lipid from Algal Biomass

Cytotoxicity, genotoxicity, oxidative stress, and apoptosis in HepG2 cells induced by the imidazole ionic liquid 1‐dodecyl‐3‐methylimidazolium chloride

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