Ionic Liquids: Promising Approach for Oral Drug Delivery

Jiang, Lin-Xia; Sun, Yi; An, Lu; Wang, Xiangyu; Shi, Yujie

doi:10.1007/s11095-022-03260-8

Cited by 15 publications

(9 citation statements)

References 73 publications

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“…At first, we should determine the route of administration. ILs have been developed for a diverse range of delivery routes, such as intravenous, 33 intramuscular, 34 transdermal, 35 oral, 36 buccal 37 and intranasal 38 formulations. Based on this, we will tailor the administration approach across different diseases in further exploration.…”

Section: Resultsmentioning

confidence: 99%

Biocompatible diimidazolium based ionic liquid systems for enhancing the solubility of paclitaxel

Hu,

Yue,

Huang

et al. 2024

Green Chem.

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Section: Resultsmentioning

confidence: 99%

Biocompatible diimidazolium based ionic liquid systems for enhancing the solubility of paclitaxel

Hu,

Yue,

Huang

et al. 2024

Green Chem.

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“…[6] Furthermore, the in vivo delivery of hydrophobic UAAs remains a formidable challenge due to their poor solubility and formulation difficulties. [13,14] The rapid metabolism and the consequent requirement for high and frequent dosages of UAAs exacerbate the cost and complexity of treatments. [15][16][17] Ionic liquids (ILs) and deep eutectic solvents, known for their high tunability and ease of preparation, present a promising solution.…”

Section: Introductionmentioning

confidence: 99%

“…[ 6 ] Furthermore, the in vivo delivery of hydrophobic UAAs remains a formidable challenge due to their poor solubility and formulation difficulties. [ 13 , 14 ] The rapid metabolism and the consequent requirement for high and frequent dosages of UAAs exacerbate the cost and complexity of treatments. [ 15 , 16 , 17 ]…”

Section: Introductionmentioning

confidence: 99%

Unnatural Amino Acid‐Based Ionic Liquid Enables Oral Treatment of Nonsense Mutation Disease in Mice

Shi,

Yang

et al. 2024

Advanced Science

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This investigation addresses the challenge of suboptimal unnatural amino acid (UAA) utilization in the site‐specific suppression of nonsense mutations through genetic code expansion, which is crucial for protein restoration and precise property tailoring. A facile and economical oral liquid formulation is developed by converting UAAs into ionic liquids, significantly enhancing their bioavailability and tissue accumulation. Empirical data reveal a 10‐fold increase in bioavailability and up to a 13‐fold rise in focal tissue accumulation, alongside marked improvements in UAA incorporation efficiency. A 4‐week oral administration in mdx mice, a model for Duchenne muscular dystrophy (DMD), demonstrates the formulation's unprecedented therapeutic potential, with up to 40% dystrophin expression restoration and 75% recovery of normal fiber functions, surpassing existing treatments and exhibiting substantial long‐term safety. This study presents a potent oral dosage form that dramatically improves UAA incorporation into target proteins in vivo, offering a significant advance in the treatment of nonsense mutation‐mediated disorders and holding considerable promise for clinical translation.

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“…Most surprisingly, whereas the other branches have been demonstrating evident growth (Energetics and Toxicity) or have reached a plateau (Green chemistry, Fine-tuned biological activity, and Medicine) during the last two decades, research on mechanistic aspects of IL-induced toxicity (Mechanisms of toxicity) seems stagnant in comparison. The topic of the biological activity of ILs, in particular, their toxicity toward various biological systems and organisms, has been addressed in details in numerous reviews, including recent reviews. ,,− Possible applications of ILs in medicine comprise a separate scientific branch, which has its share of reviews. ,− However, to the best of our knowledge, almost no attempts to systematize and generalize the available data from the viewpoint of mechanisms of IL-related toxicity have been made thus far. We think the time has come to present such a review to the IL-dedicated scientific society.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

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The review presents a detailed discussion of the evolving field studying interactions between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes to present multiapplication substances, ILs have found usage across various fields due to their exceptional physicochemical properties, including excellent tunability. However, their interactions with biological systems and potential influence on living organisms remain largely unexplored. This review examines the cytotoxic effects of ILs on cell cultures, biomolecules, and vertebrate and invertebrate organisms. Our understanding of IL toxicity, while growing in recent years, is yet nascent. The established findings include correlations between harmful effects of ILs and their ability to disturb cellular membranes, their potential to trigger oxidative stress in cells, and their ability to cause cell death via apoptosis. Future research directions proposed in the review include studying the distribution of various ILs within cellular compartments and organelles, investigating metabolic transformations of ILs in cells and organisms, detailed analysis of IL effects on proteins involved in oxidative stress and apoptosis, correlation studies between IL doses, exposure times and resulting adverse effects, and examination of effects of subtoxic concentrations of ILs on various biological objects. This review aims to serve as a critical analysis of the current body of knowledge on IL-related toxicity mechanisms. Furthermore, it can guide researchers toward the design of less toxic ILs and the informed use of ILs in drug development and medicine.

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Ionic Liquids: Promising Approach for Oral Drug Delivery

Cited by 15 publications

References 73 publications

Biocompatible diimidazolium based ionic liquid systems for enhancing the solubility of paclitaxel

Biocompatible diimidazolium based ionic liquid systems for enhancing the solubility of paclitaxel

Unnatural Amino Acid‐Based Ionic Liquid Enables Oral Treatment of Nonsense Mutation Disease in Mice

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

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