Ionic Liquids as Matrixes for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Armstrong, Daniel W.; Zhang, Li‐Kang; He, Lixia; Gross, Michael L.

doi:10.1021/ac010259f

Cited by 471 publications

(419 citation statements)

References 43 publications

(67 reference statements)

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“…3 High molecular weight, 7 liquid, 8 inorganic and two-phase matrices 1 have all been utilised to overcome some of these problems. More recently, the use of ionic liquid matrices has become widespread 9 and the conditions required for the effective use of the matrix suppression effect (MSE) have been investigated. 10 The use of graphite as a matrix [11][12][13] and the utilisation of graphite target plates, without the addition of a standard crystalline matrix, 14 was discussed in our earlier publication, 15 where graphite powder and graphite rod were investigated as possible matrices for the analysis of actinides.…”

mentioning

confidence: 99%

2B or not 2B, that is the question: further investigations into the use of pencil as a matrix for matrix‐assisted laser desorption/ionisation

Langley

Herniman

Townell

2006

Rapid Comm Mass Spectrometry

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The effective use of pencil as a matrix for matrix-assisted laser desorption/ionisation (MALDI) for the study of actinides has previously been demonstrated (Black et al., Rapid Commun. Mass Spectrom. 2006; 20: 1053). Here, the scope of the types of molecules amenable to analysis by this method has been extended, establishing that $90% of a library containing 50 diverse small molecules can be successfully analysed by this technique. Further, the role played by the bulk materials present in the different pencil leads has been investigated and a simple one-step deposition of matrix and calibration materials has been achieved through the fabrication of different calibration pencils (Cali-Pens).

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confidence: 99%

2B or not 2B, that is the question: further investigations into the use of pencil as a matrix for matrix‐assisted laser desorption/ionisation

Langley

Herniman

Townell

2006

Rapid Comm Mass Spectrometry

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“…Similar to MALDI-MS applications, IL matrices were examined on the basis of ionization efficiencies as well as [159] and [163] signal enhancement. Using the best performing IL-based matrix, a high throughput ME-SIMS method that allowed for the analysis of 600 cells/h was developed with tandem MS for the detection and identification of metabolic signatures.…”

Section: Ils In Msmentioning

confidence: 99%

Ionic liquids: solvents and sorbents in sample preparation

Clark

Emaus

Varona

et al. 2017

J of Separation Science

140

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The applications of ionic liquids (ILs) and IL-derived sorbents are rapidly expanding. By careful selection of the cation and anion components, the physicochemical properties of ILs can be altered to meet the requirements of specific applications. Reports of IL solvents possessing high selectivity for specific analytes are numerous and continue to motivate the development of new IL-based sample preparation methods that are faster, more selective, and environmentally benign compared to conventional organic solvents. The advantages of ILs have also been exploited in solid/polymer formats in which ordinarily nonspecific sorbents are functionalized with IL moieties in order to impart selectivity for an analyte or analyte class. Furthermore, new ILs that incorporate a paramagnetic component into the IL structure, known as magnetic ionic liquids (MILs), have emerged as useful solvents for bioanalytical applications. In this rapidly changing field, this Review focuses on the applications of ILs and IL-based sorbents in sample preparation with a special emphasis on liquid phase extraction techniques using ILs and MILs, IL-based solid-phase extraction, ILs in mass spectrometry, and biological applications. K E Y W O R D Salternative solvents, ionic liquids, magnetic ionic liquids, microextraction, sample preparation

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“…There have been many applications of ILs, including solvents for organic synthesis and liquidliquid extraction [1][2][3][4][5], gas chromatography stationary phases [6 -12] matrix assisted laser desorption/ionization (MALDI) matrices [13][14][15][16][17][18][19] and recently as ion pairing reagents for the trace analysis of anions by electrospray ionization mass spectrometry in the positive mode [20 -22].…”

Section: T Here Has Been Considerable Interest In the Properties And mentioning

confidence: 99%

“…These "hot spots" lead to poor shot to shot reproducibility. Other problems associated with solid matrices are difficult sample preparation, analyte size and/or type restrictions for different matrices [14], and harsh conditions used for preparation of the matrix [23]. Difficulty in sample preparation is typically caused by the analyte disrupting crystallization.…”

Section: T Here Has Been Considerable Interest In the Properties And mentioning

confidence: 99%

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Towards a second generation of ionic liquid matrices (ILMs) for MALDI-MS of Peptides, proteins, and carbohydrates

Crank

Armstrong

2009

J. Am. Soc. Mass Spectrom.

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Second generation ionic liquid matrices are developed, examined, and tested. They have shown a wide mass detection range (Ͻ1000 Da to Ͼ270,000 Da) for proteins and peptides with greater S/N ratios than solid matrices. These ionic liquid matrices also exhibit the ability to effectively ionize proteins of large mass without disrupting noncovalent interactions between monomers. Both the anionic and cationic moieties have been varied systematically to find an ionic liquid matrix with the best physical properties, analyte signal intensity, and widest mass detection range. It was determined that both the proton affinity and pK a of the cation have a large effect on the ionic liquid matrices' ability to effectively ionize the analyte. The ionic liquid matrices can be used to detect polysaccharides with fewer degradation products than solid matrices. N,N-diisopropylethylammonium ␣-cyano-4-hydroxycinnamate and N-isopropyl-Nmethyl-t-butylammonium ␣-cyano-4-hydroxycinnamate were the best matrices for proteins and peptides, while N,N-diisopropylethylammonium ␣-cyano-4-hydroxycinnamate and N,Ndiisopropylethylammonium ferulate were the best matrices for carbohydrates. (J Am Soc

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Ionic Liquids as Matrixes for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Cited by 471 publications

References 43 publications

2B or not 2B, that is the question: further investigations into the use of pencil as a matrix for matrix‐assisted laser desorption/ionisation

2B or not 2B, that is the question: further investigations into the use of pencil as a matrix for matrix‐assisted laser desorption/ionisation

Ionic liquids: solvents and sorbents in sample preparation

Towards a second generation of ionic liquid matrices (ILMs) for MALDI-MS of Peptides, proteins, and carbohydrates

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